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Mouse (Murine) PLAU Protein expressed in Insect Cells - ABIN2544531
Novak, Bryer, Cheng, Nguyen, Conley, Cunningham, Xue, Sisson, You, Hornberger, Koh: Macrophage-specific expression of urokinase-type plasminogen activator promotes skeletal muscle regeneration. in Journal of immunology (Baltimore, Md. : 1950) 2011
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Human PLAU Protein expressed in Human - ABIN491612
Reichel, Uhl, Lerchenberger, Puhr-Westerheide, Rehberg, Liebl, Khandoga, Schmalix, Zahler, Deindl, Lorenzl, Declerck, Kanse, Krombach: Urokinase-type plasminogen activator promotes paracellular transmigration of neutrophils via mac-1, but independently of urokinase-type plasminogen activator receptor. in Circulation 2011
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Mouse (Murine) PLAU Protein expressed in Insect Cells - ABIN2544476
Zhang, Kernan, Thomas, Collins, Song, Li, Zhu, Leboeuf, Eddy: A novel signaling pathway: fibroblast nicotinic receptor alpha1 binds urokinase and promotes renal fibrosis. in The Journal of biological chemistry 2009
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Human PLAU Protein expressed in Insect Cells - ABIN491607
Wu, Catano, Echeverry, Torre, Haile, An, Chen, Cheng, Nicholson, Tong, Park, Yepes: Urokinase-type plasminogen activator promotes dendritic spine recovery and improves neurological outcome following ischemic stroke. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2014
Mouse (Murine) PLAU Protein expressed in Insect Cells - ABIN2544534
Bryer, Fantuzzi, Van Rooijen, Koh: Urokinase-type plasminogen activator plays essential roles in macrophage chemotaxis and skeletal muscle regeneration. in Journal of immunology (Baltimore, Md. : 1950) 2008
Human PLAU Protein expressed in Human - ABIN491028
Komissarov, Florova, Idell: Effects of extracellular DNA on plasminogen activation and fibrinolysis. in The Journal of biological chemistry 2011
Human PLAU Protein expressed in Insect Cells - ABIN491613
Kim, Tirloni, Radulovic, Lewis, Bakshi, Hill, da Silva Vaz, Logullo, Termignoni, Mulenga: Conserved Amblyomma americanum tick Serpin19, an inhibitor of blood clotting factors Xa and XIa, trypsin and plasmin, has anti-haemostatic functions. in International journal for parasitology 2015
Rabbit PLAU Protein expressed in Insect Cells - ABIN2544614
Komissarov, Florova, Azghani, Karandashova, Kurdowska, Idell: Active ?-macroglobulin is a reservoir for urokinase after fibrinolytic therapy in rabbits with tetracycline-induced pleural injury and in human pleural fluids. in American journal of physiology. Lung cellular and molecular physiology 2013
Gelsolin (显示 GSN 蛋白) enhances the invasive capacity of colon cancer cells via elevating intracellular superoxide (O2.-) levels by interacting with Cu/ZnSOD (显示 SOD1 蛋白), and gelsolin (显示 GSN 蛋白) gene expression positively correlates with urokinase plasminogen (显示 PLG 蛋白) activator (uPA (显示 PRAP1 蛋白)), an important matrix-degrading protease invovled in cancer invasion.
the optimal discrimination cut-off for each cytokine: sVEGFR-1 (2124.5pg/mL), IL-6 (显示 IL6 蛋白) (40.2pg/mL), VEGF-A (显示 VEGFA 蛋白) (1060.1pg/mL), Angiopoeintin-2 (913.7pg/mL), uPA (显示 PRAP1 蛋白) (248.1pg/mL), sHER-2/neu (显示 ERBB2 蛋白) (5010pg/mL) and PLGF (显示 PGF 蛋白) (93.4pg/mL). For the very first time, a novel cytokine profile associated with cancer metastasis to the paratracheal lymph nodes were reported.
Study provides evidence that the stimulation of u-PA/u-PAR (显示 PLAUR 蛋白) system contributes to the activated phenotype and function of cancer-associated fibroblasts during multiple myeloma.
OB-Rb (显示 LEPR 蛋白), RhoA (显示 RHOA 蛋白)/ROCK, PI3K (显示 PIK3CA 蛋白)/AKT (显示 AKT1 蛋白), JAK (显示 JAK3 蛋白)/STAT (显示 STAT1 蛋白) pathways and NF-kB activation are involved in leptin (显示 LEP 蛋白)-induced upA (显示 PRAP1 蛋白) expression.
Results provide evidence that uPA (显示 PRAP1 蛋白) and IGF1R (显示 IGF1R 蛋白) directly interact with uPAR (显示 PLAUR 蛋白) enhancing malignant potential of triple-negative breast cancer.
suggest that the low endogenous levels of uPA (显示 PRAP1 蛋白) in blood are actively regulated, and that the regulatory mechanisms are disrupted in QPD in a megakaryocyte-specific manner
an intricate link between caveolin-1 (显示 CAV1 蛋白) and Src kinase (显示 CSK 蛋白)-mediated cell signaling and alveolar epithelial cell apoptosis due to loss of SP-C (显示 SFTPC 蛋白) expression through p53 (显示 TP53 蛋白) and uPA (显示 PRAP1 蛋白) system-mediated cross-talk, is reported.
results show that the uPA (显示 PRAP1 蛋白)/uPAR (显示 PLAUR 蛋白)/LRP1 (显示 LRP1 蛋白) system is a potential target for the development of therapeutic strategies to promote axonal recovery following a CNS injury
The present research concluded that aspirin suppressed prostate cancer cell invasion by reducing MMP-9 (显示 MMP9 蛋白) activity and uPA (显示 PRAP1 蛋白) expression through decreasing of IKK-beta (显示 IKBKB 蛋白)-mediated NF-kappaB (显示 NFKB1 蛋白) activation, indicating that the ability of aspirin to inhibit cell invasion might be useful in the chemoprevention of metastatic prostate cancer.
These studies identify uPA (显示 PRAP1 蛋白)-dependent de-repression of vegfr1 (显示 FLT1 蛋白) and vegfr2 (显示 KDR 蛋白) gene transcription through binding to HHEX/PRH (显示 HHEX 蛋白) as a novel mechanism by which uPA (显示 PRAP1 蛋白) mediates the pro-angiogenic effects of VEGF (显示 VEGFA 蛋白) and identifies a potential new target for control of pathologic angiogenesis.
Lymphangioleiomyomatosis is fatal lung disease associated with germline/somatic inactivating mutations in TSC2 genes. Data suggest lung lymphangioleiomyomatosis lesions and renal angiomyolipomas overexpress uPA; Tsc2-/- (or Tsc1 (显示 TSC1 蛋白)-/-) embryonic fibroblasts from knockout mice express higher uPA levels than wild-type cells. (uPA = urokinase-type plasminogen activator; Tsc (显示 SLC12A3 蛋白) = tuberous sclerosis complex protein)
The findings suggest that the absence of uPA correlates with increased levels of Runx transcriptional regulators in a way that promotes inflammation-associated carcinogenesis.
an intricate link between caveolin-1 (显示 CAV1 蛋白) and Src kinase (显示 CSK 蛋白)-mediated cell signaling and alveolar epithelial cell apoptosis due to loss of SP-C (显示 SFTPC 蛋白) expression through p53 (显示 TP53 蛋白) and uPA system-mediated cross-talk, is reported.
These studies identify uPA-dependent de-repression of vegfr1 (显示 FLT1 蛋白) and vegfr2 (显示 KDR 蛋白) gene transcription through binding to HHEX/PRH (显示 HHEX 蛋白) as a novel mechanism by which uPA mediates the pro-angiogenic effects of VEGF (显示 VEGFA 蛋白) and identifies a potential new target for control of pathologic angiogenesis.
Significance of the urokinase-type plasminogen activator and its receptor in the progression of focal segmental glomerulosclerosis in clinical and mouse models.
GM-CSF (显示 CSF2 蛋白) and uPA are required for Porphyromonas gingivalis-induced alveolar bone loss in a mouse periodontitis model.
Plau deficiency does not worsen controlled cortical impact-induced brain pathology or epileptogenesis caused by TBI.
we have firstly shown a fundamental mechanism of urokinase system(uPa and uPAR (显示 PLAUR 蛋白))-dependent regulation of the trajectory of growth and branching of blood vessels in early embryogenesis and in adults during the repair/regeneration of tissues.
Pharmacological inhibition of either uPA or selected MMPs decreased atherosclerosis in transgenic uPA mice.
Study shows that the competitive expression or activity of tPA (显示 PLAT 蛋白) and/or PAI-1 (显示 SERPINE1 蛋白), rather than an altered uPA expression, determines the plasmin (显示 PLG 蛋白)-mediated Abeta (显示 APP 蛋白) proteolysis in brains affected by Alzheimer's disease
uPA-mediated arterial constriction is a vasomotor process that is mediated by uPA catalytic activity, not by the NH(2)-terminal domains.
Data show that urokinase-type plasminogen activator (uPA) is only expressed in the cumulus cells of immature and in vitro matured cumulus-oocyte complexes (COCs), while uPA receptor (uPAR (显示 PLAUR 蛋白)) and plasminogen activator inhibitor-1 (PAI-1 (显示 SERPINE1 蛋白)) are expressed in both the cumulus cells and the immature and in vitro matured oocytes.
uPA/uPAR (显示 PLAUR 蛋白) binding is involved in signaling pathways that activate transcription factors that regulate the synthesis of molecules concerned with the arrangement of a particular oviductal microenvironment.
These data indicated that E. coli LPS (显示 IRF6 蛋白) led to an increase in u-PA activity and RNA expression of u-PA and u-PAR (显示 PLAUR 蛋白) in BME-UV1 cells, thus strengthening the role of the PA system during pathological processes.
The plasminogen/plasminogen (显示 PLG 蛋白) activator/plasmin (显示 PLG 蛋白) system is activated during gamete interaction and regulates the sperm entry into the oocyte.
stage-dependent regulation of granulosa cell PA and SerpinE2 (显示 SERPINE2 蛋白) production, consistent with a role in extracellular matrix remodeling during follicle growth.
This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
urokinase-type plasminogen activator
, U-plasminogen activator
, plasminogen activator, urokinase
, plasminogen activator, urinary
, Urinary plasminogen activator, urokinase
, urokinase plasminogen activator preproprotein