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NFKBIL-1 affects the pathogenesis of rheumatoid arthritis at least in part by the regulation of dendritic cell functions.
genetic association studies in a population of black women in South Africa: Data suggest that an SNP in NFKBIL1 (rs2071592) is associated with iron status/iron-deficiency anemia in the population studied.
These observations suggest a functional involvement of IkappaBL in the regulation of alternative splicing in both human and viral genes, which is a novel link of HLA locus to the regulation of immunity and infection in humans.
an association was noted between IKBL-62T and idiopathic inflammatory myopathy, with increased risk noted in anti-Jo-1- and -PM-Scl antibody-positive patients; the IKBL-62T association is dependent on TNF-308A and HLA-B*08, due to strong shared linkage disequilibrium between these alleles
results do not provide evidence for the association between the -62A/T NFKBIL1 polymorphism and obsessive-compulsive disorder in this Brazilian sample.
Results of the present study do not provide evidence for the association between the NFKBIL1 exon 4 polymorphism and MS predisposition in the investigated Polish population.
The DPB1 (显示 HLA-DPB1 蛋白) gene controlled the severity of the vascular lesion, whereas the IKBL gene (NFKBIL1) was associated with a relatively mild phenotype.
study shows that the estimated haplotype IkBL -421 8T/-62 T tends to be associated with susceptibility to rheumatoid arthritis in Taiwan
analysis of the NFKB1 protein polymorphism interactions with CARD15/NOD2, IKBL, and IL-1RN genes
Minor homozygous genotypes of polymorphisms in NFKBIL1 were associated with moderately protective effects against myocardial infarction.
The IKBL locus itself or another critical gene in this region may confer susceptibility to the development of chronic Chagas cardiomyopathy.
This gene encodes a divergent member of the I-kappa-B family of proteins. Its function has not been determined. The gene lies within the major histocompatibility complex (MHC) class I region on chromosome 6. Multiple transcript variants encoding different isoforms have been found for this gene.
, NF-kappa-B inhibitor-like protein 1
, inhibitor of kappa B-like protein
, nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
, NF-kappaB inhibitor-like protein 1
, inhibitor of Rel family transcription factors