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Human MMP 9 Protein expressed in Human Cells - ABIN2002581
Opdenakker, Van den Steen, Dubois, Nelissen, Van Coillie, Masure, Proost, Van Damme: Gelatinase B functions as regulator and effector in leukocyte biology. in Journal of leukocyte biology 2001
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Rat (Rattus) MMP 9 Protein expressed in Human Cells - ABIN3218785
Belotti, Paganoni, Manenti, Garofalo, Marchini, Taraboletti, Giavazzi: Matrix metalloproteinases (MMP9 and MMP2) induce the release of vascular endothelial growth factor (VEGF) by ovarian carcinoma cells: implications for ascites formation. in Cancer research 2003
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Most of the SNPs are still uncharacterized thereby present study provides a direction that can help to validate the relation between the altered expressions and functions of MMP9 protein in terms of disease susceptibility.
The SNP rs17576 was found to be significantly associated with susceptibility to Lumbar Disc Herniation (LDH), which was also confirmed by haplotype-based analyses (rs79845319-rs17576-rs45437897, global p < 0.001). Our results indicated that the A allele of rs17576 reduced the risk of LDH by approximately 23% on average. Furthermore, the G allele of rs17576 was found to correlate with more severe grades of disc degenera...
Coxsackievirus A16 infection enhanced blood-brain barrier by directly upregulation of MMP9.
Matrix metalloproteinase-9 gene polymorphisms and their interaction with environment on subarachnoid hemorrhage risk.
Our findings also suggest that prostate cancer cells may utilize AR, EGFR and MMP-9 pathways in androgen-dependent as well as in castration-resistant conditions. Our data suggest a new therapeutic potential to block cancer metastasis by targeting AR, EGFR and MMP-9 pathways in subsets of prostate cancer patients.
a critical role of TET2 in regulating trophoblast cell migration through demethylation at the MMP9 promoter
The rs2274755 SNP in the MMP-9 gene was significantly associated with NTG. This supports a possible role of the MMP-9 gene in NTG pathogenesis
Aging mice with macrophage overexpression of matrix metalloproteinase-9 have increased macrophage numbers 7 days after myocardial infarction, resulting in improved diastolic physiology and left ventricular remodeling through effects on cardiac wound healing.
Data suggests that MMP-9 polymorphism does not facilitate predisposition for papillary thyroid carcinoma but affects the disease course by modulating MMP-9 expression.
Cyclic peptides 1, 2, 46 also displayed potential interaction with active residues of MMP9; thus, these cyclic peptides can serve as potential drug candidates to block MMP9 activity and future studies are warranted to confirm their efficacy.
Our findings indicate that monitoring serum MMP-9 and detection of histological MMP-9 could help identify TNBC patients who will respond to NAC and will display varying risks of disease relapse. MMP-9 may serve as a predictive and prognostic biomarker for tailoring and modifying the NAC strategy for TNBC.
significantly increased in the serum of type 2 diabetes mellitus patients with diabetic retinopathy
Study evaluated for the first time the plasma levels and the diagnostic usefulness of VEGF, MMP-9, and TIMP-1 in cervical cancer (CC), not only independently but especially in combination with established cervical tumor markers. All tested parameters showed statistical significance when compared their concentrations in patients with CC to healthy women.
In monocytes, incubation with psoriasis' sera increased the production of MMP-9 and TIMP-1 in comparison with both baseline and monocytes incubated with non-psoriatic sera
CTHRC1 serves as a pro-metastatic gene that contributes to NSCLC invasion and metastasis, which are mediated by upregulated MMP7 and MMP9 expression. Targeting CTHRC1 may be beneficial for inhibiting NSCLC metastasis.
High mmp9 expression is associated with Endometrial adenocarcinoma.
There was studied the level of matrix metalloproteinase-9 (MMP-9) in plasma of bone marrow aspirates in 87 patients: 39 with acute myeloid leukemia (AML) and 48 myelodysplastic syndrome (MDS). It has been found out an association of the level of MMP-9 in plasma of bone marrow aspirates in patients with AML and MDS with a volume of leukemic mass.
This study provides the first evidence for the involvement of polymorphisms within MMP9 and the severity of childhood trauma in antipsychotic treatment response
HOXD-AS1 was upregulated in non-small cell lung carcinoma tissues and cell lines and promoted NSCLC cell proliferation, migration invasion via sponging miR-133b and regulating MMP9.
rs3918241, rs2250889, rs17576 and rs17577 polymorphisms of MMP-9 are not associated with altered risk of urinary cancer.
MMP-9 overexpression increased the number of mice that exhibited traumatic brain injury-induced spontaneous seizures, and MMP-9 knockout decreased the appearance of seizures.
omega-3 reduces MMP-9 gene expression and improves myoblast engraftment, satellite cell activation, and muscle regeneration by mechanisms involving, at least in part, the regulation of macrophages.
These results indicated that MMP-9/2 activation in spinal microglia plays a key role in incision-induced mechanical allodynia in mice.
PARP-1, via manipulating the binding of NF-kB/AP-1 at the MMP-9 promoter, regulates MMP-9 expression, which helps maintain mitochondrial homeostasis.
fracture union in matrix metalloproteinase 9 deficient mice
Study in inflammatory bowel disease (IBD) Mmp-9 knock-out mice model found no differences in clinical or histopathological parameters after genetic or pharmacological inhibition of MMP-9. Therefore suggesting that MMP-9 upregulation is a consequence of the inflammatory process and unlikely represents a therapeutic target in IBD.
our findings demonstrate that MMP9 is important for tooth development and DSP is a novel target of MMP9 during dentinogenesis.
The findings support the correlation between age-related hearing loss and cognitive decline in C57BL/6J mice, and indicated that MMP9 expression in the auditory cortex and hippocampus may be associated with the underlying mechanisms.
In the initial periods of AP progression, an increased expression of MMP9 in the TLR2 KO and MyD88 KO mice was observed. In the final periods of AP progression, a reduction of MMP2 expression and an increase of MMP9 expression in the TLR2 KO mice were observed. MMP2 and MMP9 production was modulated for TLR2 and MyD88 during apical periodontitis progression
Our data suggest that MMP-9 deficiency does not result in major abnormalities in the development of any conventionally selected or agonist selected subsets and does not interfere with thymocyte apoptosis and clearance, and that MMP-9 expression is not induced in immature T cells at any stage of their thymic development.
analysis of Foxn1 and Mmp-9 expression in the intact and postinjured skin of young, adult, and old C57BL/6J and transgenic Foxn1::Egfp mice
Diet and exercise affect atheromatous MMP2/9 activity by modulating the systemic inflammatory milieu, with sVCAM-1, resistin, and adiponectin closely interacting with each other and with visceral fat.
Myocardial MMP-9 inhibition prevents ventricular arrhythmia through pleiotropic effects, including the modulation of calcium homeostasis and reduced calcium leakage.
results first identified the role of SNX10 in MMP9 trafficking and secretion, and provided an evidence for SNX10 as a possible therapeutic target for bone destructing disease.
Thus, the light reintroduction-induced increase in MMP-9 removes constraints on structural and functional plasticity in the mature cortex.
the ZnT3 null state removed synaptic zinc, it rather increased free zinc in the cytosol of brain cells, which appeared to increase MMP-9 activity and BDNF levels. The present results suggest that zinc dyshomeostasis during the critical period of brain development may be a possible contributing mechanism for ASD.
MMP-9 activation by hypoxia requires LRP1 and Pyk2 phosphorylation in fibroblasts.
Aneurysmal-prone factors induced HIF-1alpha can cause overexpression of MMP-2 and MMP-9 and promote aneurysmal progression.
These results demonstrate that OPN expressed by fatigue-resistant/slow motor neurons is involved in the second-wave neurodegeneration by up-regulating MMP-9 through alphavbeta3 integrin in the mouse model of amyotrophic lateral sclerosis.
via binding to hypoxia-responsive elements in MMP9 gene, HIF1alpha stimulated MMP9 expression, and therefore appeared as a prominent intermediary in HB-EGF-induced blood-brain barrier damage
elevated in placentas of mares retaining fetal membranes
Results provide evidence for the utility of MMP9 and TIMP1 as markers of age- and lactocrine-sensitive porcine female reproductive tract development.
Increased MMP-9 expression is associated with carotid atherosclerotic plaque.
For A3011G, the GG genotype was associated with a significantly higher (p < 0.05) number of live births than those recorded for AA sows and the additive effect was significant
Increased expression of MMP-9 is associated with intraplaque hemorrhage in a swine model of vulnerable carotid atherosclerosis
we demonstrated the presence of high molecular weight (HMW) complexes (130, 170, and 220 kDa) containing MMP9, TIMP1, and NGAL (also MMP2 in 220 kDa complex) without proteolytic activity.
Data demonstrate for the first time that MMP2 and MMP9 are expressed in swine ovarian follicle both in theca and granulosa layers.
FiO2 used for resuscitation affects matrix metalloproteinases MMP-9 and MMP-2, caspase-3 and BDNF
Oxygen for newborn resuscitation increases MMP-2/-9 activity resulting in tissue damage and influencing remodeling processes.
contribution of MMPs to the inflammatory breakdown of the blood-CSF barrier in vitro
The levels of matrix metalloproteinase-2 and matrix metalloproteinase-9 (MMP-9)in the corpus luteum of swine during luteolysis are reported.
Our data define pericyte interactions as a main inducer of endothelial MMP secretion and propose a new role for pericyte-endothelial cell crosstalk at the BBB in vitro
Variable gene expression (eg, matrix metalloproteinase-9, CCL2 and Lp-PLA(2) mRNAs), both in regard to the arterial bed and duration of disease, was associated with variable plaque development and progression.
Hemodialysis graft placement leads to early increases in wall shear stress, VEGF-A, pro-MMP-9, MMP-2, VEGFR-1, VEGFR-2, and TIMP-1, which may contribute to the development of venous stenosis.
The expression of MMP2 and MMP9 in lung injury induced by mechanical stress, hypoxic injury, and septic shock in anesthetized swine are reported.
In diabetic retinopathy transcription of MMP-9 is regulated by AP-1 binding at both, proximal and distal sites of its promoter, and acetylation of c-Jun and c-Fos subunits is important in its regulation.
These data demonstrate that serum neutrophil haptoglobin-MMP 9 complexes appear sooner and decline more rapidly than other acute phase proteins.
Activation of cytosolic MMP-9 and MMP-2 was investigated in the retinal endothelial cells incubated in high glucose for 6-96 h, and correlated with their mitochondrial accumulation and mitochondrial damage.
Role of TGF-beta1 and TNF-alpha in IL-1beta mediated activation of proMMP-9 in pulmonary artery smooth muscle cells: involvement of an aprotinin sensitive protease.
Decreased MMP-9 and increased TIMP-1 expression were found in peripheral blood cells from Mycobacterium avium subsp. paratuberculosis (Map)-infected cattle after stimulation with Map lysate and Map purified protein derivative than in control cattle.
We used a trophoblast cell line (F3) derived from bovine placentomes to examine the influence of EGF on MMP-9 and TIMP-1 expression by semiquantitative RT-PCR and MMP activity by zymography.
expression of mRNA and protein during deciduous tooth resorption in odontoclasts
results suggest a significant role of matrix metalloproteinase-2 and-9 in growth and development of bovine follicle
Cells constitutively produced proMMP-9 and proMMP-2, and treatment with TNFalpha, hepatocyte growth factor, and 12-O-tetradecanoylphorbol 13-acetate resulted in significant increase in level of proMMP-9 but not in level of proMMP-2.
MMP-2 and MMP-9 production in blastocysts attached to the endometrial cells is regulated by TNF-alpha and TNF-beta
Results suggest that MMP-2, MMP-9, and TIMP-2 mRNAs are expressed in bovine placentomes during the gestational and postpartum periods and that these enzymes, in conjunction with steroidogenic enzymes, mediate fetal membrane detachment after parturition.
In cervix, MMP9 is only active during the final cervical ripening process at parturition.
Relative expression of MMP-9 and MMP-2 increased in synovial fluid from calves with experimentally induced septic arthritis, with relative expression remaining high for several days after E. coli infection.
The expression level of MMP-9 was stably maintained, but was relatively low compared to that of MMP-2 during bovine gestation.
Mmp9 is dispensable for Hematopoietic stem cells budding, and is required for proper colonization of secondary niches.
The findings of this study suggest that Mmp-9 is a protective molecule against infection by Listeria monocytogenes by engaging in migration of zebrafish macrophages to the site of infection via a non-proteolytic role.
elevated beta-oxidation-fuelled mitochondria-derived reactive oxygen species within epidermal cells helps guide matrix metalloproteinase-driven leukocyte recruitment.
Mmp9 regulates both acute and chronic tissue damage and plays an essential role in collagen reorganization during wound repair.
MeHg impairs tail development at least partially by activation of the tissue remodeling proteases Mmp9 and Mmp13.
study identified mechanism by which mycobacteria induce granulomas: ESAT-6 induced MMP9 in epithelial cells neighboring infected macrophages; MMP9 enhanced recruitment of macrophages, which contributed to nascent granuloma maturation & bacterial growth
From 24h post fertilization, mmp9 expression was detected in a population of circulating white blood cells.
expression and activity of MMP-2 and MMP-9 in the embryonic zebrafish.
The MMP-9 gene was duplicated and differentiated into two genes, one was specialized in a common ancestor of X. laevis and X. tropicalis expressed in degenerating and remodeling organs in response to thyroid hormone during metamorphosis.
MMP-9TH is responsible in the larval epithelial apoptosis through degrading ECM components in the basal lamina, whereas MMP-9 is involved in the removal of dying epithelial cells during amphibian intestinal remodeling
metamorphic tail and intestine RNA levels of TIMP-2, MT1-MMP and Gel-A, but not MT3-MMP or TIMP-3, are elevated during periods of cell death and proliferation
matrix metalloproteinases 7, 9, and 18 are required in vivo for macrophage migration during embryonic development
The present study demonstrated the ability of 30 and 100 ng/ml TIMP3 to attenuate migration and proliferation, and to inhibit the activity of MMP2, MMP9 and TNFalpha secretion of NA SMCs. In conclusion, TIMP3 may be considered a potential therapeutic drug for use in a novel drugeluting stent, to attenuate the progressive dilation of the aortic NA.
Expression of MMP-9 increased after cerebral aneurysm induction, peaking at week 3, leading to reduced smooth muscle cell number, damaged endothelial cells, and damage to the aneurysm wall elastic layer.
Inflammatory factors such as TNF-alpha can stimulate MMP-2/9 activity in corneal epithelium cells. This may be a potential manipulating mechanism of MMP expression in the pathogenesis of corneal diseases
Therefore, it was reasonable to speculate that the increased expression of VEGF and MMP-9 in residual hepatic tumor cells and tumor angiogenesis post-embolization would be responsible for the increased metastatic potentiality and invasiveness.
Performing minimally invasive surgical procedures in the early stages of intracerebral hemorrhage significantly decreases MMP-9.
Increased expression of MMP-9 in spinal cord follows cervical spondylotic myelopathy.
Hemoperfusion could obviously reduce oxidative stress and the expression levels of MMP-2, MMP-9 and TIMP-1 in rabbits with acute paraquat poisoning.
Exposure to long periods of light irrespective of its characteristics leads to the increased expression of some matrix metalloprpteases.
In experimental syringomyelia, MMP-9 plays an important role in causing edema in the presyrinx state.
Tongxinluo can inhibit the expression of MMP-3 and 9 and increase the expression of PPARgamma in atherosclerotic rabbits.
MMP promoter activation occurs as a function of thoracic aorta wall tension in transgenic mice
TGF-beta mediated MMP-9 induction may be regulated by the NF-kappaB, Smad3, and JNK pathways, whereas the IL-1beta mediated induction may be regulated by the NF-kappaB and p38 pathways.
The results showed that MMP-2, MMP-9, and StAR were significantly expressed in the granulosa and thecal cells of the ovarian atretic follicles during proestrus, and were strongly expressed in the corpus luteum during metestrus.
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling.
92 kDa gelatinase
, 92 kDa type IV collagenase
, macrophage gelatinase
, matrix metalloproteinase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
, matrix metalloproteinase-9
, type V collagenase
, 92kD gelatinase
, 92kD type IV collagenase
, 92kDa gelatinase
, 92kDa type IV collagenase
, Gel B
, collagenase type IVB
, gelatinase B
, matrix metalloproteinase 9
, 92-kDa type IV collagenase
, matrix metalloproteinase 9 (gelatinase B 92-kDa type IV collagenase)
, matrix metalloproteinase 9 (gelatinase B, 92-kDa type IV collagenase)
, type IV collagenase MMP-9
, Matrix metalloproteinase-9
, matrix metalloproteinase 9 (gelatinase B, 92kDa matrix metalloproteinase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
, 75 kDa gelatinase