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Human MMP 9 Protein expressed in Human Cells - ABIN2002581
Opdenakker, Van den Steen, Dubois, Nelissen, Van Coillie, Masure, Proost, Van Damme: Gelatinase B functions as regulator and effector in leukocyte biology. in Journal of leukocyte biology 2001
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Rat (Rattus) MMP 9 Protein expressed in Human Cells - ABIN3218785
Belotti, Paganoni, Manenti, Garofalo, Marchini, Taraboletti, Giavazzi: Matrix metalloproteinases (MMP9 and MMP2) induce the release of vascular endothelial growth factor (VEGF) by ovarian carcinoma cells: implications for ascites formation. in Cancer research 2003
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Our findings indicate that overexpression of MMP-9 rescued insulin (显示 INS 蛋白) survival signaling in vitro and in early stages in the 5XFAD model of AD.
Review/Meta-analysis: Matrix metalloproteinase-9 has high predictive value for hemorrhagic transformation after acute ischemic stroke.
In dilation cardiomyopathy, expression of MMP-2 (显示 MMP2 蛋白), MMP-9, and TIMP-1 (显示 TIMP1 蛋白) and their ratios in autopsy material and in cultures was elevated by 1.5-9 times.
The expression of MMP-9 is associated with clinical outcome in chondrosarcoma.
OSM (显示 OSM 蛋白) [oncostatin M (显示 OSM 蛋白)]might be involved in the invasiveness of extravillous trophoblasts under hypoxia conditions via increasing MMP-2 (显示 MMP2 蛋白) and MMP-9 enzymatic activities through STAT3 (显示 STAT3 蛋白) signaling. Increased MMP-9 activity by OSM (显示 OSM 蛋白) seems to be more important in primary trophoblasts.
MMP-9 levels in the tumor tissue extracts had also increased significantly
MMP-9 -1562 C/T polymorphism might be related to the digestive cancer susceptibility [meta-analysis]
MMP-9 protein overexpression was found in prostate cancers, low expression in any of the normal tissues or in benign prostatic tissue
Hypoxia promotes retinoblastoma cell line HXO-RB44 invasion by activating HIF-1alpha (显示 HIF1A 蛋白)/MMP9 signaling pathway.
There was no difference found in MMP-2 (显示 MMP2 蛋白), MMP-9 or TLR-4 (显示 TLR4 蛋白) levels between non-thrombocytopenic and thrombocytopenic septic donors. PLA formation was increased in thrombocytopenic patients.
In the initial periods of AP progression, an increased expression of MMP9 in the TLR2 KO and MyD88 (显示 MYD88 蛋白) KO mice was observed. In the final periods of AP progression, a reduction of MMP2 (显示 MMP2 蛋白) expression and an increase of MMP9 expression in the TLR2 KO mice were observed. MMP2 (显示 MMP2 蛋白) and MMP9 production was modulated for TLR2 and MyD88 (显示 MYD88 蛋白) during apical periodontitis progression
Our data suggest that MMP-9 deficiency does not result in major abnormalities in the development of any conventionally selected or agonist selected subsets and does not interfere with thymocyte apoptosis and clearance, and that MMP-9 expression is not induced in immature T cells at any stage of their thymic development.
analysis of Foxn1 (显示 FOXN2 蛋白) and Mmp-9 expression in the intact and postinjured skin of young, adult, and old C57BL/6J and transgenic Foxn1 (显示 FOXN2 蛋白)::Egfp mice
Diet and exercise affect atheromatous MMP2/9 activity by modulating the systemic inflammatory milieu, with sVCAM-1, resistin, and adiponectin closely interacting with each other and with visceral fat.
Myocardial MMP-9 inhibition prevents ventricular arrhythmia through pleiotropic effects, including the modulation of calcium homeostasis and reduced calcium leakage.
results first identified the role of SNX10 (显示 SNX10 蛋白) in MMP9 trafficking and secretion, and provided an evidence for SNX10 (显示 SNX10 蛋白) as a possible therapeutic target for bone destructing disease.
Thus, the light reintroduction-induced increase in MMP-9 removes constraints on structural and functional plasticity in the mature cortex.
the ZnT3 (显示 Slc30a3 蛋白) null state removed synaptic zinc, it rather increased free zinc in the cytosol of brain cells, which appeared to increase MMP-9 activity and BDNF (显示 BDNF 蛋白) levels. The present results suggest that zinc dyshomeostasis during the critical period of brain development may be a possible contributing mechanism for ASD (显示 GUSB 蛋白).
MMP-9 activation by hypoxia requires LRP1 (显示 LRP1 蛋白) and Pyk2 (显示 PTK2B 蛋白) phosphorylation in fibroblasts.
Aneurysmal-prone factors induced HIF-1alpha (显示 HIF1A 蛋白) can cause overexpression of MMP-2 (显示 MMP2 蛋白) and MMP-9 and promote aneurysmal progression.
Results provide evidence for the utility of MMP9 and TIMP1 (显示 TIMP1 蛋白) as markers of age- and lactocrine-sensitive porcine female reproductive tract development.
Increased MMP-9 expression is associated with carotid atherosclerotic plaque.
Increased expression of MMP-9 is associated with intraplaque hemorrhage in a swine model of vulnerable carotid atherosclerosis
we demonstrated the presence of high molecular weight (HMW) complexes (130, 170, and 220 kDa) containing MMP9, TIMP1 (显示 TIMP1 蛋白), and NGAL (显示 LCN2 蛋白) (also MMP2 (显示 MMP2 蛋白) in 220 kDa complex) without proteolytic activity.
Data demonstrate for the first time that MMP2 (显示 MMP2 蛋白) and MMP9 are expressed in swine ovarian follicle both in theca and granulosa layers.
FiO2 used for resuscitation affects matrix metalloproteinases MMP-9 and MMP-2 (显示 MMP2 蛋白), caspase-3 (显示 CASP3 蛋白) and BDNF (显示 BDNF 蛋白)
Oxygen for newborn resuscitation increases MMP-2 (显示 MMP2 蛋白)/-9 activity resulting in tissue damage and influencing remodeling processes.
contribution of MMPs to the inflammatory breakdown of the blood-CSF (显示 CSF2 蛋白) barrier in vitro
The levels of matrix metalloproteinase-2 (显示 MMP2 蛋白) and matrix metalloproteinase-9 (MMP-9)in the corpus luteum of swine during luteolysis are reported.
Our data define pericyte interactions as a main inducer of endothelial MMP secretion and propose a new role for pericyte-endothelial cell crosstalk at the BBB in vitro
In diabetic retinopathy transcription of MMP-9 is regulated by AP-1 binding at both, proximal and distal sites of its promoter, and acetylation of c-Jun and c-Fos subunits is important in its regulation.
These data demonstrate that serum neutrophil haptoglobin (显示 HP 蛋白)-MMP 9 complexes appear sooner and decline more rapidly than other acute phase proteins.
Activation of cytosolic MMP-9 and MMP-2 (显示 MMP2 蛋白) was investigated in the retinal endothelial cells incubated in high glucose for 6-96 h, and correlated with their mitochondrial accumulation and mitochondrial damage.
Role of TGF-beta1 (显示 TGFB1 蛋白) and TNF-alpha (显示 TNF 蛋白) in IL-1beta (显示 IL1B 蛋白) mediated activation of proMMP-9 in pulmonary artery smooth muscle cells: involvement of an aprotinin sensitive protease.
Decreased MMP-9 and increased TIMP-1 (显示 TIMP1 蛋白) expression were found in peripheral blood cells from Mycobacterium avium subsp. paratuberculosis (Map)-infected cattle after stimulation with Map lysate and Map purified protein derivative than in control cattle.
We used a trophoblast cell line (F3) derived from bovine placentomes to examine the influence of EGF (显示 EGF 蛋白) on MMP-9 and TIMP-1 (显示 TIMP1 蛋白) expression by semiquantitative RT-PCR and MMP activity by zymography.
results suggest a significant role of matrix metalloproteinase-2 (显示 MMP2 蛋白) and-9 in growth and development of bovine follicle
Cells constitutively produced proMMP-9 and proMMP-2, and treatment with TNFalpha (显示 TNF 蛋白), hepatocyte growth factor (显示 HGF 蛋白), and 12-O-tetradecanoylphorbol 13-acetate resulted in significant increase in level of proMMP-9 but not in level of proMMP-2.
MMP-2 and MMP-9 production in blastocysts attached to the endometrial cells is regulated by TNF-alpha and TNF-beta
Results suggest that MMP-2 (显示 MMP2 蛋白), MMP-9, and TIMP-2 (显示 TIMP2 蛋白) mRNAs are expressed in bovine placentomes during the gestational and postpartum periods and that these enzymes, in conjunction with steroidogenic enzymes, mediate fetal membrane detachment after parturition.
Mmp9 is dispensable for Hematopoietic stem cells budding, and is required for proper colonization of secondary niches.
The findings of this study suggest that Mmp-9 is a protective molecule against infection by Listeria monocytogenes by engaging in migration of zebrafish macrophages to the site of infection via a non-proteolytic role.
elevated beta-oxidation-fuelled mitochondria-derived reactive oxygen species within epidermal cells helps guide matrix metalloproteinase-driven leukocyte recruitment.
Mmp9 regulates both acute and chronic tissue damage and plays an essential role in collagen reorganization during wound repair.
MeHg impairs tail development at least partially by activation of the tissue remodeling proteases Mmp9 and Mmp13 (显示 MMP13 蛋白).
study identified mechanism by which mycobacteria induce granulomas: ESAT-6 induced MMP9 in epithelial cells neighboring infected macrophages; MMP9 enhanced recruitment of macrophages, which contributed to nascent granuloma maturation & bacterial growth
From 24h post fertilization, mmp9 expression was detected in a population of circulating white blood cells.
expression and activity of MMP-2 (显示 MMP2 蛋白) and MMP-9 in the embryonic zebrafish.
The MMP-9 gene was duplicated and differentiated into two genes, one was specialized in a common ancestor of X. laevis and X. tropicalis expressed in degenerating and remodeling organs in response to thyroid hormone (显示 PTH 蛋白) during metamorphosis.
MMP-9TH is responsible in the larval epithelial apoptosis through degrading ECM (显示 MMRN1 蛋白) components in the basal lamina, whereas MMP-9 is involved in the removal of dying epithelial cells during amphibian intestinal remodeling
metamorphic tail and intestine RNA levels of TIMP-2 (显示 TIMP2 蛋白), MT1-MMP (显示 MMP14 蛋白) and Gel-A, but not MT3-MMP (显示 MMP24 蛋白) or TIMP-3 (显示 TIMP3 蛋白), are elevated during periods of cell death and proliferation
Expression of MMP-9 increased after cerebral aneurysm induction, peaking at week 3, leading to reduced smooth muscle cell number, damaged endothelial cells, and damage to the aneurysm wall elastic layer.
Inflammatory factors such as TNF-alpha (显示 TNF 蛋白) can stimulate MMP-2 (显示 MMP2 蛋白)/9 activity in corneal epithelium cells. This may be a potential manipulating mechanism of MMP expression in the pathogenesis of corneal diseases
Therefore, it was reasonable to speculate that the increased expression of VEGF (显示 VEGFA 蛋白) and MMP-9 in residual hepatic tumor cells and tumor angiogenesis post-embolization would be responsible for the increased metastatic potentiality and invasiveness.
Performing minimally invasive surgical procedures in the early stages of intracerebral hemorrhage significantly decreases MMP-9.
Increased expression of MMP-9 in spinal cord follows cervical spondylotic myelopathy.
Hemoperfusion could obviously reduce oxidative stress and the expression levels of MMP-2 (显示 MMP2 蛋白), MMP-9 and TIMP-1 (显示 TIMP1 蛋白) in rabbits with acute paraquat poisoning.
In experimental syringomyelia, MMP-9 plays an important role in causing edema in the presyrinx state.
Tongxinluo can inhibit the expression of MMP-3 (显示 MMP3 蛋白) and 9 and increase the expression of PPARgamma (显示 PPARG 蛋白) in atherosclerotic rabbits.
TGF-beta (显示 TGFB1 蛋白) mediated MMP-9 induction may be regulated by the NF-kappaB (显示 NFKB1 蛋白), Smad3 (显示 SMAD3 蛋白), and JNK (显示 MAPK8 蛋白) pathways, whereas the IL-1beta (显示 IL1B 蛋白) mediated induction may be regulated by the NF-kappaB (显示 NFKB1 蛋白) and p38 (显示 MAPK14 蛋白) pathways.
The results showed that MMP-2 (显示 MMP2 蛋白), MMP-9, and StAR were significantly expressed in the granulosa and thecal cells of the ovarian atretic follicles during proestrus, and were strongly expressed in the corpus luteum during metestrus.
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling.
92 kDa gelatinase
, 92 kDa type IV collagenase
, macrophage gelatinase
, matrix metalloproteinase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
, matrix metalloproteinase-9
, type V collagenase
, 92kD gelatinase
, 92kD type IV collagenase
, 92kDa gelatinase
, 92kDa type IV collagenase
, Gel B
, collagenase type IVB
, gelatinase B
, matrix metalloproteinase 9
, 92-kDa type IV collagenase
, matrix metalloproteinase 9 (gelatinase B 92-kDa type IV collagenase)
, matrix metalloproteinase 9 (gelatinase B, 92-kDa type IV collagenase)
, type IV collagenase MMP-9
, Matrix metalloproteinase-9
, matrix metalloproteinase 9 (gelatinase B, 92kDa matrix metalloproteinase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
, 75 kDa gelatinase