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Mouse (Murine) IL-10 Protein expressed in Escherichia coli (E. coli) - ABIN1305073
Howard, OGarra, Ishida, de Waal Malefyt, de Vries: Biological properties of interleukin 10. in Journal of clinical immunology 1992
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Rat (Rattus) IL-10 Protein expressed in Escherichia coli (E. coli) - ABIN1305077
Feng, Tang, Chang, Wilson: Molecular cloning of rat cytokine synthesis inhibitory factor (IL-10) cDNA and expression in spleen and macrophages. in Biochemical and biophysical research communications 1993
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Human IL-10 Protein expressed in Escherichia coli (E. coli) - ABIN413418
van der Vliet, Wang, Yue, Koon, Balk, Exley: Circulating myeloid dendritic cells of advanced cancer patients result in reduced activation and a biased cytokine profile in invariant NKT cells. in Journal of immunology (Baltimore, Md. : 1950) 2008
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Human IL-10 Protein expressed in Escherichia coli (E. coli) - ABIN1305072
Vieira, de Waal-Malefyt, Dang, Johnson, Kastelein, Fiorentino, deVries, Roncarolo, Mosmann, Moore: Isolation and expression of human cytokine synthesis inhibitory factor cDNA clones: homology to Epstein-Barr virus open reading frame BCRFI. in Proceedings of the National Academy of Sciences of the United States of America 1991
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Human IL-10 Protein expressed in Escherichia coli (E. coli) - ABIN988023
Yang, Hirose, Takahashi, Kawakatsu, Takaiwa: Recombinant protein yield in rice seed is enhanced by specific suppression of endogenous seed proteins at the same deposit site. in Plant biotechnology journal 2012
Mouse (Murine) IL-10 Protein expressed in Escherichia coli (E. coli) - ABIN988022
Larson, Hübner, Torrero, Morris, Brankin, Swierczewski, Davies, Vonakis, Mitre: Chronic helminth infection reduces basophil responsiveness in an IL-10-dependent manner. in Journal of immunology (Baltimore, Md. : 1950) 2012
Our meta-analysis indicated that the IL10-1082 G/A polymorphism is associated with recurrent aphthous stomatitis susceptibility, especially in Asians
Suggest that IL-10 rs1800871 and PRKDC (显示 PRKDC 蛋白) rs7003908 may be useful biomarkers for predicting glioma patient survival.
In vitro deletion of A20 (显示 TNFAIP3 蛋白) compromised the expression of IL10 in B regulatory cells.
IL-10 from M2 macrophage promoted proliferation of glioma through interaction with JAK2 (显示 JAK2 蛋白).
IL-6 (显示 IL6 蛋白), IL-8 (显示 IL8 蛋白), and IL-10 circulating levels were shown to be higher in cases of infection. Further studies are needed to recommend a routine practice for predicting culture-confirmed bacterial infections.
Primary open angle glaucoma in type 2 diabetes: Implications of the IL-10/STAT3 (显示 STAT3 蛋白)-mediated anti-inflammatory response
IL-10 is up-regulated in an ERK (显示 EPHB2 蛋白)- and p38 (显示 CRK 蛋白)-dependent fashion in Chlamydia trachomatis stimulated peripheral blood mononuclear cells; IL-10 inhibits the production of pro-inflammatory cytokines by activating the JAK (显示 JAK3 蛋白)/STAT (显示 STAT1 蛋白) signalling pathway
The genotype and allele distribution of IL-10 (-A592C) gene polymorphism was significantly different between OSCC cases and controls (genotype AA vs AC: OR 2.87; 95 % CI 1.50-5.48; p = 0.0016 and AA vs CC: OR 4.08; 95 % CI 1.98-8.41; p = 0.0002). The -592 C alleles were found to be significantly different among OSCC cases and controls (OR: 1.44, 95% CI: 1.12-1.85, p < 0.0051).
this study reveals a key role of IL-10 in controlling cellular metabolism via inhibiting mTORC1, and this metabolic control by IL-10 is critical to control of inflammation.
This review summarizes the paradoxic effects of IL-10 on different types of immune responses, and proposes that different cellular sources of IL-10, in particular IL-10-secreting helper and regulatory T-cells, have different effects on B-cell and CTL responses. Based on this concept we discuss the rationales for targeting the IL-10 pathway in immune-mediated diseases and cancer.
in vivo IL-10 treatment increased fibroblast activation (proliferation, migration, and collagen production), an effect that was both directly and indirectly influenced by macrophage M2 polarization
Suggest that the IL-17A (显示 IL17A 蛋白)/IL-10/STAT3 (显示 STAT3 蛋白) signaling pathway plays a crucial role in the pathogenesis of hepatic fibrosis by suppressing hepatocellular autophagy and that blocking this pathway may provide therapeutic benefits for the treatment of hepatic fibrosis.
Mechanistic studies suggest a PKC-Syk (显示 SYK 蛋白)-mediated signaling pathway, to which IL-10 conversely inhibits, is required for activating macrophage self-targeting, followed by phagocytosis independent of calreticulin (显示 CALR 蛋白) Moreover, we identified spleen red pulp to be one specific tissue that provides stimuli constantly activating macrophage phagocytosis albeit lacking in Cd47 (显示 CD47 蛋白)(-/-) or Sirpalpha(-/-) mice.
High IL10 expression is associated with lung cancer.
The activation of STAT3 (显示 STAT3 蛋白) was much higher in Gal12 (显示 LGALS12 蛋白)(-/-) macrophages activated by lipopolysaccharide, which was correlated with higher levels of IL-10. Adipocytes showed higher insulin (显示 INS 蛋白) sensitivity when treated with Gal12 (显示 LGALS12 蛋白)(-/-) macrophage-conditioned media than those treated with Gal12 (显示 LGALS12 蛋白)(+/+) macrophages.
IL-10-MSCs offered superior protection against LPS (显示 TLR4 蛋白)-induced ALI.
methane-rich saline may activate the PI3K-AKT (显示 AKT1 蛋白)-GSK-3beta pathway to induce IL-10 expression and produce anti-inflammatory effects via the NF-kappaB (显示 NFKB1 蛋白) and MAPK (显示 MAPK1 蛋白) pathways. The findings provide a new pharmacological strategy for management of inflammatory response after acute liver injury.
plasma adiponectin and leptin (显示 LEP 蛋白) were also decreased in IL 10tm.These findings suggest that frailty observed in this mouse model of chronic inflammation may in part be driven by alterations in fat mass, hormone secretion and energy metabolism
We believe that current findings derived from human and mouse experiments will promote the development of new drugs and therapies based on IL-10 modulation, which may enhance host immunity and bacterial clearance during infection. However, because IL-10 can play both favorable and unfavorable effects over the host depending on the bacterial infection, it may act as a double edge sword.
This study seems to indicate that PGE2 in cattle does not produce an anti-inflammatory effect by increasing the synthesis of IL-10.
IL-10 mRNA expression increased on day 8 in the mononuclear leukocytes of pregnant cows. In a cell culture experiment, interferon-tau stimulated stimulated IL-10 mRNA expression in mononuclear leukocytes.
Bovine IL-10 potently inhibits the activation of human myeloid cells in response to toll (显示 TLR4 蛋白) like receptor activation.
Monocytes obtained from cows with subclinical infection with MAP had upregulated expression of IL-10 and SOCS-3 (显示 SOCS3 蛋白), which may have attenuated the capacity of mononuclear phagocytes to initiate inflammatory and adaptive immune responses.
The ability of an EHV-1 isolate to down-regulate IL-10 production might contribute to increased local inflammation and a higher risk for neurological manifestation of the disease after infection with Ab4.
The data suggested in foals there is an impaired Th2 response, the immune response is Th1 (显示 TH1L 蛋白) biased, interferon-gamma (显示 IFNG 蛋白) production is qualitatively similar to adult horses, and regulatory IL-10 production by T cells is mature.
serum IL-6 (显示 IL6 蛋白):IL-10 ratio is likely to provide a valuable prognosticator for neonatal septicemia
The contribution of bronchial epithelium to airway inflammation, with focus on mRNA and protein expression of IL-6 (显示 IL6 蛋白), IL-10 and TNF-alpha (显示 TNF 蛋白), in horses with recurrent airway obstruction during exacerbation and in remission is reported.
The complete open reading frame consists of 537 base pairs which encodes a protein of 179 amino acids. This cDNA sequence exhibited 87% homology with human IL-10.
ICAM1 (显示 ICAM1 蛋白) and IL10 were upregulated in ventilator-induced lung injury. Nuclear transcription factor AP-1 (显示 JUN 蛋白) may be responsible for this upregulation.
The PRRSV vaccination induced higher levels of IL-10 expression in the first week and this may be why the CSFV vaccination is immunosuppressed.
These data indicate that the type 2 porcine reproductive and respiratory syndrome virus N protein plays an important role in IL-10 induction and the N-N non-covalent domain is associated with this activity.
The effects of semen, spermatozoa in extender, or extender alone on the expression of TGF-beta1 (显示 TGFB1 蛋白), IL-10, and IL-6 (显示 IL6 蛋白) in ovarian follicles are reported.
Prostaglandin E2 potentiates mesenchymal stem cell-induced IL-10+IFN-gamma (显示 IFNG 蛋白)+CD4 (显示 CD4 蛋白)+ regulatory T cells to control transplant arteriosclerosis.
Porcine reproductive and respiratory syndrome virus strain CH-1a could significantly up-regulate IL-10 production through p38 MAPK (显示 MAPK14 蛋白) activation.
Boar seminal plasma contained TGF- beta1 (显示 TGFB1 蛋白) and IL-10 but with high individual variation.
Changes in interleukin-10 mRNA expression are predictive for 9-day survival of pigs in an emergency preservation and resuscitation model.
These results suggest that TNF-alpha (显示 TNF 蛋白) and IL-10, but not IL-6 (显示 IL6 蛋白), are involved in the late reparatory phases of the experimental disk lesion.
The present study shows that elevated levels of serum CRP (显示 CRP 蛋白) and IL-10 were associated with porcine circovirus type 2-infected piglets that subsequently developed severe PMWS.(postweaning multisystemic wasting syndrome)
Subclinically porcine circovirus type 2 (PCV2)-infected pigs developed a transient PCV2-specific IL-10 response during the viremic phase of infection which coincided with the inversion of the IgM/IgG ratio.
IL-10 produced during the immune response to malaria in this model contributes to suppression of mucosal inflammatory responses to invasive NTS (显示 NTS 蛋白), which may contribute to differences in the clinical presentation of NTS (显示 NTS 蛋白) infection in the setting of malaria.
Findings demonstrate that internalization of IL-10R with the resultant impact on IL-10 signaling and dysregulation of the IL-10-mediated anti-inflammatory responses might play a crucial role in epithelial cell damage and subsequent simian immunodeficiency virus pathogenesis.
IL-10 plays a crucial role in maintaining mucosal homeostasis by regulating mucosal IFNgamma and TNFalpha (显示 TNF 蛋白) cytokine production.
The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.
T-cell growth inhibitory factor
, cytokine synthesis inhibitory factor
, uncharacterized protein LOC100715618
, Cytokine synthesis inhibitory factor