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MMP-7 (显示 MMP7 蛋白)-dependent procryptdin activation in vivo provides mouse Paneth cells with functional peptides for apical secretion into the small intestine lumen
cryptdin 3 forms anion-selective channels on the cytoplasmic membrane of HEK (显示 EPHA3 蛋白) cells and that the kinetics of one such channel are affected by its interaction with other such channels.
DEFA1 (显示 DEFA1 蛋白), DEFA3, and PPBP (显示 PPBP 蛋白) expression was significantly increased in hyperlipidemia and coronary heart disease patients compared with controls.
these results demonstrate that HNPs1-3 may be potent inhibitors of ADAMTS13 (显示 ADAMTS13 蛋白) activity, likely by binding to the central A2 domain of VWF (显示 VWF 蛋白) and physically blocking ADAMTS13 (显示 ADAMTS13 蛋白) binding.
High HNP3 expression is associated with IgA Nephropathy.
Elevated DEFA3 levels in diabetes are independent of DEFA3 copy numbers.
DEFA3 encodes an antibacterial peptide that is bacteriocidal against S. aureus, E. coli, and P. aeruginosa.
A decrease in salivary HNP 1 (显示 DEFA1 蛋白)-3 levels might be a biological factor for predisposition to oral ulcers in patients with Behcet disease and oral infection in healthy patients.
Results indicate that the gene expression of DEFA 1 (显示 DEFA1 蛋白)/3 and 4 was significantly increased in all tumours - except for a significant decrease of DEFA 4 (显示 DEFA4 蛋白) gene expression in pleomorphic adenomas.
alpha-Defensin (显示 DEF 蛋白) (DEFA3)was the third most differentially overexpressed gene and may be related to the onset of Bell's palsy and Ramsay Hunt Syndrome.
Increased levels of human neutrophil peptides 1, 2, and 3 in peritoneal fluid of patients with endometriosis: association with neutrophils, T cells and IL-8 (显示 IL8 蛋白).
HNP1 (显示 DEFA1 蛋白)-3 concentrations in patients with multidrug-resistant tuberculosis were significantly lower than in drug-susceptible pulmonary TB and healthy controls
Defensins are a family of microbicidal and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. The protein encoded by this gene, defensin, alpha 3, is found in the microbicidal granules of neutrophils and likely plays a role in phagocyte-mediated host defense. Several alpha defensin genes are clustered on chromosome 8. This gene differs from defensin, alpha 1 by only one amino acid. This gene and the gene encoding defensin, alpha 1 are both subject to copy number variation.
neutrophil defensin 3
, Paneth cell-specific alpha-defensin 3
, alpha-defensin 3, neutrophil-specific
, alpha-defensin 3
, defensin, alpha, 27
, defensin-related cryptdin-3
, defensin 3, neutrophil-specific
, neutrophil peptide 3