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Rat (Rattus) CCL2 Protein expressed in Escherichia coli (E. coli) - ABIN1305099
Capsoni, Minonzio, Ongari, Zanussi: A new simplified single-filter assay for 'in vitro' evaluation of chemotaxis of 51Cr-labeled polymorphonuclear leukocytes. in Journal of immunological methods 1989
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Mouse (Murine) CCL2 Protein expressed in Escherichia coli (E. coli) - ABIN1305100
Ernst, Zhang, Hancock, Rutledge, Corless, Rollins: Biochemical and biologic characterization of murine monocyte chemoattractant protein-1. Identification of two functional domains. in Journal of immunology (Baltimore, Md. : 1950) 1994
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Human CCL2 Protein expressed in Escherichia coli (E. coli) - ABIN1305101
Rollins, Stier, Ernst, Wong: The human homolog of the JE gene encodes a monocyte secretory protein. in Molecular and cellular biology 1990
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Mouse (Murine) CCL2 Protein expressed in Escherichia coli (E. coli) - ABIN935595
Bogen, Dina, Gear, Levine: Dependence of monocyte chemoattractant protein 1 induced hyperalgesia on the isolectin B4-binding protein versican. in Neuroscience 2009
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Human CCL2 Protein expressed in Escherichia coli (E. coli) - ABIN935639
Frøyland, Pedersen, Kvissel, Almaas, Pharo, Skålhegg, Mollnes, Rootwelt: Effect of acidosis on IL-8 and MCP-1 during hypoxia and reoxygenation in human NT2-N neurons. in Brain research 2006
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Mouse (Murine) CCL2 Protein expressed in Escherichia coli (E. coli) - ABIN413594
Gray, Di Marco, Okabe, Szyndralewiez, Heitz, Montezano, de Haan, Koulis, El-Osta, Andrews, Chin-Dusting, Touyz, Wingler, Cooper, Schmidt, Jandeleit-Dahm: NADPH oxidase 1 plays a key role in diabetes mellitus-accelerated atherosclerosis. in Circulation 2013
Mouse (Murine) CCL2 Protein expressed in Escherichia coli (E. coli) - ABIN413564
Zhu, Daghini, Chade, Rodriguez-Porcel, Napoli, Lerman, Lerman: Role of oxidative stress in remodeling of the myocardial microcirculation in hypertension. in Arteriosclerosis, thrombosis, and vascular biology 2006
The meta-analysis demonstrated that urinary MCP-1 was significantly higher in patients with active LN than in those with inactive LN and control subjects, and the patients with inactive LN showed significantly higher urinary MCP-1 levels than the controls.
investigated whether functional polymorphism at MCP-1 regulatory region associates with disease phenotype in Indian systemic lupus erythematosus patients (SLE) patients; findings suggest that -2518G allele of MCP-1 -2518 A/G polymorphism is associated with renal disorders and may influence MCP-1 gene expression among Indian SLE patients
joint interaction analysis of ACE I/D and CCL2 C-2518T showed a significantly higher frequency of II genotype of ACE I/D in coexistence with TT genotype of CCL2 C-2518T in Henoch-Schonlein purpura (HSP) patients.
EGF (显示 EGF 蛋白) up-regulated CCL2 expression in HNSCC cells, which recruited monocytes and turned them into M2-like macrophages, thus forming a positive feedback paracrine loop.
CCL2 gene silencing inhibits primary tumor growth and metastasis, associated with a reduction in cancer stem cell renewal and recruitment of M2 macrophages in triple negative breast cancer
Mesenchymal stem cells from Ankylosing spondylitis patients secreted more monocyte chemoattractant protein 1 (MCP1) during abnormal osteogenic differentiation.
CCL2 polymorphism is associated with susceptibility to latent tuberculous infection in well-defined North-East Thai populations.
Meta-analysis suggests that the MCP-1-2518A/G polymorphism is associated with an increased risk of lupus nephritis.
Association of polymorphic markers of chemokine (显示 CCL1 蛋白) genes, their receptors, and CD14 (显示 NDUFA2 蛋白) gene with coronary atherosclerosis
CCL2 is associated with decreased recurrence-free survival in patients with basal-like breast cancer patients.
Study demonstrated that CD36 (显示 CD36 蛋白) deletion regulated MCP-1 (显示 CPT1B 蛋白) expression at the transcriptional level by changing the acetylation of histones binding to the MCP-1 (显示 CPT1B 蛋白) promoters in hepatocytes, promoting macrophage migration to the liver, and aggravating hepatic inflammatory response and fibrosis.
Despite higher caloric intake and elevated body weights, carbohydrate restriction lowered serum MCP-1 (显示 CPT1B 蛋白) levels, reduced prostate macrophage infiltration, reduced prostate weight, but failed to slow adenocarcinoma development.
Data indicate that ASC (显示 STS 蛋白)-J9(R) can suppress CD4 (显示 CD4 蛋白)+ T cell migration via decreasing the cytokine CCL2 in vitro and in vivo.
PDAC responds to radiotherapy by producing CCL2, which recruits Ly6C(+)CCR2(+) monocytes to support tumor proliferation and neovascularization after radiotherapy.
Chemokine receptor 2 (CCR2 (显示 CCR2 蛋白)(+)) monocytes invade the hippocampus between 1 and 3 d after SE. In contrast, only an occasional CD3 (显示 CD3E 蛋白)(+) T lymphocyte was encountered 3 d after SE. The initial cellular sources of the chemokine (显示 CCL1 蛋白) CCL2, a ligand for CCR2 (显示 CCR2 蛋白), included perivascular macrophages and microglia. The induction of the proinflammatory cytokine IL-1beta (显示 IL1B 蛋白) was greater in FACS-isolated microglia than in brain-invading monocytes
data suggest that MCP-1 (显示 CPT1B 蛋白) may be a necessary component of the inflammatory response required for adipose tissue protection, remodeling and healthy expansion in the FVB/N strain in response to high-fat diet feedings
MCP-1 (显示 CPT1B 蛋白) knockout mice exposed for voluntary wheel running displayed changes in brain cytokine expression and glial activation.
Carvedilol treatment also significantly reduced the levels of proinflammatory cytokines tumor necrosis factor (TNF)-alpha (显示 TNF 蛋白), interleukin (IL)-1beta (显示 IL1B 蛋白), IL-6 (显示 IL6 蛋白), transforming growth factor (TGF)-beta1 (显示 TGFB1 蛋白) and monocyte chemoattractant protein (MCP)-1 (显示 CPT1B 蛋白) in the lung tissue.
Both IL-6 (显示 IL6 蛋白) protein production and transcript levels were downregulated by RA in respiratory tract epithelial cells (LETs) , but upregulated in macrophages (MACs). RA also increased transcript levels of MCP-1 (显示 CPT1B 蛋白), GMCSF (显示 CSF2 蛋白), and IL-10 (显示 IL10 蛋白) in MACs, but not in LETs. Conversely, when LETs, but not MACs, were exposed to RA
FSAP (显示 HABP2 蛋白) deficiency causes an increase in CCL2 expression and CCL2-mediated infiltration of leukocytes into the injured vessel
resence of type 2 diabetes negatively affects the work of cytokines and markers of fibrosis, as evidenced by higher levels of interleukin-1beta and monocyte chemoattractant protein-1, compared with patients without diabetes
Studied SNPs in the bovine toll-like receptor 4 (TLR4 (显示 TLR4 蛋白)) and monocyte chemo attractant protein-1(CCL2) genes.
The LEP (显示 LEP 蛋白), IGF2 and CCL2 genes showed allelic expression imbalance in liver, kidney and pituitary glands of Polish Holstein-Friesian bulls.
immune cells and endothelial cells can interact cooperatively to increase CCL2 secretion in the corpus luteum
ghrelin (显示 GHRL 蛋白) can inhibit intraplaque angiogenesis and promote plaque stability by down-regulating VEGF (显示 VEGFA 蛋白) and VEGFR2 (显示 KDR 蛋白) expression, inhibiting the plaque content of macrophages, and reducing MCP-1 expression at an advanced stage of atherosclerosis in rabbits
Data show that peripheral blood endothelial progenitor cells can increase the expressions of chemokines CCL2 and CXCL12 (显示 CXCL12 蛋白) and promote the migration of enhanced green fluorescent protein-positive bone marrow stromal cells to bone defect site.
In a cerebral aneurysm, expression of MCP1 peaked after induction for one week, then decreased. MCP1 induced macrophage adhesion and infiltration in the artery wall of aneurysms, and contributed to the occurrence and development of brain aneurysm.
Data show that the serum levels of mast cell tryptase, monocyte chemoattractant protein-1 (MCP-1) and interleukin-8 (IL-8 (显示 IL8 蛋白)) decreased significantly in Dachengqi decoction treatment group.
measurements of CCL2 and macrophages can serve as new inflammatory biomarkers to evaluate the safety of promising novel microbicides for prevention of HIV.
Expression of MCP-1 was successfully inhibited by transfecting MCP-1 siRNA expression plasmid to the carotid artery, and the progression of atherosclerosis was restricted by RNAi-mediated silencing of MCP-1 expression.
CXCL10 (显示 CXCL10 蛋白) protein was detected in serum from pigs infected with a high virulence African swine fever virus isolate. Levels of CCL2 mRNA were increased in pigs infected with the high virulence isolate compared to a low virulence isolate.
Porcine CCL2 binding on Tuk4+SLA (显示 SLA 蛋白)-II- but not on Tuk4-SLA (显示 SLA 蛋白)-II+ cells was detected by using a CCL2-green fluorescence protein fusion protein.
The protective properties of flavonoids, such as EGCG, against endothelial inflammation may be regulated in part though induction of HO-1 and subsequent activator protein-1 signaling.
MCP-1 contributes to functional and structural impairment in the kidney in renal artery stenosis, mainly in the tubulointerstitial compartment
Contrast media did not affect bone marrow cell viability/MCP-1 secretion.
Porcine vessel wall injury via balloon arthroplasty upregulates expression of CCL2 by coronary artery transmural and perivascular cells in a sequential pattern.
in the aortic arch expression of monocyte chemoattractant protein 1 (MCP-1) was upregulated, compared with the thoracic aorta
Variable gene expression (eg, matrix metalloproteinase-9 (显示 MMP9 蛋白), CCL2 and Lp-PLA(2 (显示 Lp-PLA2 蛋白)) mRNAs), both in regard to the arterial bed and duration of disease, was associated with variable plaque development and progression.
myocardial infarction induced proinflammatory gene and protein expression in peripheral blood mononuclear cells of tissue factor (显示 F3 蛋白) cyclo-oxygenase-2, monocyte chemoattractant protein-1 and CRP (显示 CRP 蛋白)
This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4.
small inducible cytokine A2
, C-C motif chemokine 2
, immediate-early serum-responsive JE protein
, immediate-early serum-responsive protein JE
, monocyte chemoattractant protein 1
, monocyte chemoattractant protein-1
, monocyte chemotactic protein 1
, small inducible gene JE
, small-inducible cytokine A2
, monocyte chemotactic and activating factor
, monocyte secretory protein JE
, small inducible cytokine A2 (monocyte chemotactic protein 1, homologous to mouse Sig-je)
, small inducible cytokine subfamily A (Cys-Cys), member 2
, platelet-derived growth factor-inducible protein JE
, acidic seminal fluid protein
, monocyte chemotactic protein 1A
, chemokine CCL2/MCP-1
, antiadrenocorticotropin peptide III
, corticostatin III
, macrophage antibiotic peptide MCP-1
, mast cell protease 1A