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Human Cathelicidin Protein expressed in Escherichia coli (E. coli) - ABIN2123814
Choi, Kim, Chi, Kwon, Chang: Modulating the internalization of bacille Calmette-Guérin by cathelicidin in bladder cancer cells. in Urology 2015
these data show that LL-37 affects surface and intracellular Toll (显示 TLR4 蛋白)-Like Receptor expression in tissue mast cells
This review describes novel advances involving the roles and mechanisms of human cathelicidin LL-37 in cancer.
The findings support a role for STAT3 (显示 STAT3 蛋白) and HIF-1A (显示 HIF1A 蛋白) in the regulation of LL-37 expression.
In silico docking study have confirmed the high binding affinities of multiple 9-mer peptides derived from LL-37 to the HLA-C*06:02 molecule proposed a mechanism of the interaction between this LL-37-HLA-C*06:02 complex and T cells via TCRs.
IL-33 (显示 IL33 蛋白) down-regulates the induction of hCAP-18/LL-37 production in human gingival epithelial cells.
in teens with positive recto-vaginal group B streptococcus colonization, placental mRNA expression of cathelicidin is lower compared to those who tested negative for this infection
these results suggested that human CAMP/LL-37 might act as a tumor-suppressor in OSCC and DNA methylation (显示 HELLS 蛋白) might play roles during carcinogenesis via directly downregulating human CAMP promoter activity.
omoted epithelial and smooth-muscle-like differentiation of Adipose-derived stem cells through activating the Wnt (显示 WNT2 蛋白)/beta-catenin (显示 CTNNB1 蛋白) and NF-kappaB (显示 NFKB1 蛋白) pathways, respectively
Patients with type 1 diabetes and presence of microangiopathy characterize higher level of serum cathelicidin.
The expression of LL-37 was up-regulated in the inflamed mucosa of IBD patients. LL-37 was induced by TLR-3 (显示 TLR3 蛋白) stimulation and exhibited an anti-microbial effect via interaction with lipopolysaccharide (LPS (显示 IRF6 蛋白)).
Injection of CAP18 into juvenile rainbow trout before exposure to Yersinia ruckeri was associated with lowered mortality compared to non-medicated fish although it was less effective than the conventional antibiotic oxolinic acid.
Pattern recognition receptors such as TLR5 (显示 TLR5 蛋白) may be involved in the stimulation of cathelicidin expression, and the signalling cascade can include PI3-kinase (显示 PIK3CA 蛋白) and cellular trafficking compartments.
p15 (显示 CDKN2B 蛋白) proteins are stored in the specific (secondary) granules of rabbit neutrophils and are secreted extracellularly after inflammatory stimulation.
The p15 (显示 CDKN2B 蛋白) proteins exhibit antimicrobial synergy with another rabbit cathelicidin (CAP-18) and with the rabbit Bactericidal/permeability-increasing protein (BPI (显示 BPI 蛋白)).
Immunoblotting, qPCR, ChIP and siRNA-mediated gene knockdown studies revealed that the activation of phosphatidylinositol 3-kinase/protein kinase C zeta (显示 PRKCZ 蛋白) pathways in poly(I:C)-stimulated cells underlies Sp1 (显示 SP1 蛋白) phosphorylation and recruitment to the mCRAMP promoter, leading to enhanced transcription
The effect on insulin (显示 INS 蛋白) resistance found in Cramp-/- mice is solely due to leukocyte infiltration and not due to inflammatory phenotype of macrophages. Therefore we conclude that cathelicidin causes insulin (显示 INS 蛋白) resistance by the recruitment of myeloid cells into the adipose tissue.
Cathelicidin is required for innate resistance to M. tuberculosis in a relevant animal model and is a key mediator in regulation of the levels of pro-inflammatory cytokines by calcium and cyclic nucleotides.
overexpressed CRAMP in prostate tumor initially chemoattracts early myeloid progenitors to tumor microenvironment and mediates differentiation and polarization of early myeloid progenitors into protumorigenic M2 macrophages during PCa (显示 ENPP1 蛋白) progression
The aim of this project was to examine the functional impact of the human cathelicidin LL-37 and the mouse cathelicidin-related AMP (显示 TMPRSS5 蛋白) (CRAMP) on the pathogenesis of lupus and arthritis.
Cathelicidin, expressed by immune cells in the tumor microenvironment, promotes colon cancer growth through activation of the PTEN/PI3K/Akt (显示 AKT1 蛋白) and Wnt (显示 WNT2 蛋白)/beta-catenin (显示 CTNNB1 蛋白) signaling pathways.
pancreatic beta-cells' production is controlled by short-chain fatty acids produced by the gut (显示 GUSB 蛋白) microbiota, and is defective in non-obese diabetic (NOD) mice
Data indicate the role of cathelicidin-related antimicrobial peptide (CRAMP) as part of the innate immune defense against pathogens in bacterial CNS infections.
Hypoxia-inducible factor-1alpha (HIF-1alpha (显示 HIF1A 蛋白)), a transcription factor important for activating innate immune effectors, and the antimicrobial peptide LL-37 (CRAMP in mice) are key determinants of C. albicans colonization resistance.
Specific structural motifs in syndecan-1 (显示 SDC1 蛋白) HS promote Staphylococcus aureus corneal infection by inhibiting neutrophil CRAMP.
Characterization of single nucleotide polymorphisms (SNPs) and insertion-deletion (indel) polymorphisms within the bovine CATHL (显示 CTSL1 蛋白) gene family.
This gene encodes a member of an antimicrobial peptide family, characterized by a highly conserved N-terminal signal peptide containing a cathelin domain and a structurally variable cationic antimicrobial peptide, which is produced by extracellular proteolysis from the C-terminus. The encoded protein has several functions in addition to antimicrobial activity, including cell chemotaxis, immune mediator induction and inflammatory response regulation.
18 kDa cationic antimicrobial protein
, cathelicidin antimicrobial peptide
, cathelicidin-derived antimicrobial peptide 2
, 18 kDa cationic protein
, 18 kDa lipopolysaccharide-binding protein
, antimicrobial protein CAP18
, cathelin-like protein
, cathelin-related antimicrobial peptide
, cathelicidin 2
, myeloid antimicrobial peptide 27
, antimicrobial peptide
, antibacterial peptide BMAP-34
, cathelicidin 7
, neutrophil cationic antibacterial polypeptide of 11 kDa