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Human Polyclonal PGK1 Primary Antibody for FACS, IF - ABIN391135
Danshina, Geyer, Dai, Goulding, Willis, Kitto, McCarrey, Eddy, OBrien: Phosphoglycerate kinase 2 (PGK2) is essential for sperm function and male fertility in mice. in Biology of reproduction 2009
Show all 6 Pubmed References
Human Polyclonal PGK1 Primary Antibody for ELISA, ICC - ABIN4345073
Khurana, Laskar, Bhattacharyya, Bhattacharyya: Hsp90 induces increased genomic instability toward DNA-damaging agents by tuning down RAD53 transcription. in Molecular biology of the cell 2016
Human Polyclonal PGK1 Primary Antibody for IHC (p), WB - ABIN391250
Garzón, Gayarre, Gharbi, Díez-Dacal, Sánchez-Gómez, Timms, Pérez-Sala: A biotinylated analog of the anti-proliferative prostaglandin A1 allows assessment of PPAR-independent effects and identification of novel cellular targets for covalent modification. in Chemico-biological interactions 2009
PGK1 is used to indicate the prognosis of hepatocellular carcinoma (HCC (显示 FAM126A 抗体)).
Data show that LINC00963 (MetaLnc9) interacted with the glycolytic kinase PGK1 and prevented its ubiquitination in non-small cell lung cancer (NSCLC) cells, leading to activation of the oncogenic AKT (显示 AKT1 抗体)/mTOR (显示 FRAP1 抗体) signaling pathway.
Acetylated PGK1 binds to and phosphorylates Beclin1 (显示 BECN1 抗体) at S30 (显示 FAU 抗体), leading to activation of the VPS34 (显示 PIK3C3 抗体)-Beclin1 (显示 BECN1 抗体) complex to initiate autophagosomal formation.
Data suggest that, in breast cancer cells, MYC (显示 MYC 抗体) acts as an upstream regulator leading to PGK1 activation. (MYC (显示 MYC 抗体), proto-oncogene c-myc (显示 MYC 抗体); PGK1, phosphoglycerate kinase 1)
PGK1, a glycolytic enzyme catalyzing the conversion of 3-phosphoglycerate into 2-phosphoglycerate, has increased expression in synovial tissues and blood of rheumatoid arthritis, which may be involved in pro-inflammation and synovial hyperplasia of the disease
In neuroblastoma (显示 ARHGEF16 抗体) cells, CAIX (显示 CA9 抗体) and PGK1 expression is up regulated under hypoxia and correlates with response to targeted anti-proliferative treatment.
Mitochindrial PGK1 acts as a protein kinase in coordinating glycolysis and the tricarboxylic acid cycle, which is instrumental in cancer metabolism and tumorigenesis.
PI3K (显示 PIK3CA 抗体)/AKT (显示 AKT1 抗体)/mTOR (显示 FRAP1 抗体) pathway regulates HDAC3 (显示 HDAC3 抗体) S424 phosphorylation, which promotes HDAC3 (显示 HDAC3 抗体)-PGK1 interaction and PGK1 K220 deacetylation
Retinal dystrophy (显示 MERTK 抗体) may be one of the clinical manifestations of phosphoglycerate kinase deficiency.
Results show that PGK1 mRNA and protein expression were significantly increased in breast cancer tissues and can be considered as a prognostic biomarker of chemoresistance to paclitaxel treatment in breast cancer.
present in, and accounts for, glycolysis and glutamate (显示 GRIN2A 抗体) accumulation into synaptic vesicles
Pgk1 overexpression, or treatment with terazosin (an FDA-approved small molecule that binds and activates Pgk1), rescued motor axon phenotypes in SMA zebrafish. We conclude that global bioenergetics pa (显示 SMN1 抗体)thways can be therapeutically manipulated to ameliorate SMA motor neuron phenotypes in vivo.
Phosphoglycerate kinase is a moonlighting protein that functions as both a glycolytic enzyme and a disulfide reductase (显示 GSR 抗体).
Purification and characterization of 3-phosphoglycerate kinase from Ehrlich ascites carcinoma cells
PGK domain movement and catalysis is regulated by a spring-loaded release mechanism
Results indicate that COX-2 (显示 COX2 抗体) suppression by PGK-1 is independent of its catalytic activity.
Together, these data suggest that PGK1 secreted by PCa (显示 ENPP1 抗体) regulates bone formation at the metastatic site by increasing osteoblastic activity, decreasing osteoclastic function, and expressing an osteoblastic phenotype by PCa (显示 ENPP1 抗体) cells.
Heterozygous for the X-linked pgk-1a and pgk-1b. Clonally heterotypic glands with inactive X-specific methylation were present in the adult murine stomach.
Pgk1 is strongly expressed in the developing tooth germ of the mouse lower first molar.
Findings indicate that overexpression of PGK-1 in LLC-1 reduces the COX-2 (显示 COX2 抗体) expression, and, in turn, affect PGE2, cell invasion, angiogenesis, and the immune functions, and finally inhibit the tumor progression.
targeting of a single bioenergetic protein, phosphoglycerate kinase 1 (Pgk1), was found to modulate motor neuron vulnerability in vivo. Knockdown of pgk1 alone was sufficient to partially mimic the SMA (显示 SMN1 抗体) phenotype in wild-type zebrafish
PGK1 (phosphoglycerate kinase 1) interacts with AtFtsZ2 in planta, suggesting a possible role in FtsZ phosphorylation.
The protein encoded by this gene is a glycolytic enzyme that catalyzes the conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate. The encoded protein may also act as a cofactor for polymerase alpha. This gene lies on the X-chromosome, while a related pseudogene also has been found on the X-chromosome and another on chromosome 19.
phosphoglycerate kinase 1
, PRP 2
, cell migration-inducing gene 10 protein
, primer recognition protein 2
, phosphoglycerate kinase