TPP1 蛋白 (TPP1)产品概述

Full name:: Tripeptidyl Peptidase I 蛋白 (TPP1)

在www.antibodies-online.cn可供16 Tripeptidyl Peptidase I (TPP1) 蛋白的8不同的供货商。再加上，我们可以发TPP1 抗体 (114) 和 TPP1 试剂盒 (27)和数多这个蛋白质的别的产品。总共165 TPP1产品已列进来了。

别名:: Cln2, fa01b09, im:7149243, LPIC, TPP-1, TPP-I, wu:fa01b09

列出全部蛋白	基因	基因ID	UniProt
	TPP1	1200	O14773
	TPP1	83534	Q9EQV6
	TPP1	12751	O89023
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Human Tripeptidyl Peptidase I (TPP1) interaction partners

The reports the crystal structure of the N-terminal domain of TIN2 (显示 TINF2 蛋白) in complex with TIN2 (显示 TINF2 蛋白)-binding motifs from TPP1 and TRF2 (显示 TERF2 蛋白), revealing how TIN2 (显示 TINF2 蛋白) interacts cooperatively with TPP1 and TRF2 (显示 TERF2 蛋白).
TPP1 cleaves and destabilizes fibrillar amyloid-beta at multiple sites in a time- and pH-dependent manner.
To confirm clinical suspicion of CLN2 disease, the recommended gold standard for laboratory diagnosis is demonstration of deficient TPP1 enzyme activity (in leukocytes, fibroblasts, or dried blood spots) and the identification of causative mutations in each allele of the TPP1/CLN2 gene.
These studies indicate that optimal treatment outcomes for CLN2 disease may require delivery of TPP1 systemically as well as directly to the central nervous system.
TPP1 is overexpressed in hepatocellular carcinoma tissues and significantly correlated with poor prognosis of hepatocellular carcinoma patients.RFX5 acts as a direct positive transcriptional regulator of TPP1 in hepatocellular carcinoma.
TPP1(CLN2) mutation is associated with neuronal ceroid lipofuscinosis (显示 CLN6 蛋白).
To our knowledge, our results bring the first evidence of a mechanism that links TPP-1 deficiency and oxidative stress-induced (显示 SQSTM1 蛋白) changes in mitochondrial morphology.
hypothesize that loss of function variants abolishing TPP1 enzyme activity lead to CLN2 disease, whereas variants that diminish TPP1 enzyme activity lead to SCAR7
This study demonistrated that the CLN2 gene 4 mutation in late infantile neuronal ceroid lipofuscinosis (显示 CLN6 蛋白).
TPP1 mutants utilize the advantages of a zebrafish model for understanding the pathogenesis of late infantile (or classic late infantile neuronal ceroid lipofuscinosis (显示 CLN6 蛋白)) disease.

Mouse (Murine) Tripeptidyl Peptidase I (TPP1) interaction partners

telomeres are protected from hyper-resection through the repression of the ATM (显示 ATM 蛋白) and ATR kinases by TRF2 (显示 TERF2 蛋白) and TPP1-bound POT1a (显示 POT1 蛋白)/b, respectively.
Rssults suggested that CLN2, CLN3 (显示 CLN3 蛋白) and CLN5 (显示 CLN5 蛋白) genes may play an important role in early embryonal neurogenesis.
demonstrated that cells expressing TIN2DeltaTPP1 instead of wild-type TIN2 (显示 TINF2 蛋白) phenocopy the POT1a (显示 POT1 蛋白),b knockout setting without showing additional phenotypes
Gemfibrozil and fenofibrate, Food and Drug Administration-approved lipid-lowering drugs, up-regulate tripeptidyl-peptidase 1 in brain cells via peroxisome proliferator-activated receptor alpha (显示 PPARA 蛋白) and may have implications in late infantile Batten disease therapy
TPPI activity becomes crucial for the neuronal functions later in development.
Telomere protection by TPP1/POT1 (显示 POT1 蛋白) requires tethering to TIN2 (显示 TINF2 蛋白).
TPP1 protects telomere integrity and regulates telomerase recruitment to telomeres, thereby preventing early occurrence of degenerative skin pathologies.
TPP1 deletion resulted in the release of POT1a (显示 POT1 蛋白) and POT1b from chromatin and loss of these proteins from telomeres, indicating that TPP1 is required for the telomere association of POT1a (显示 POT1 蛋白) and POT1b but not for their stability.
Lysosomal degradation of cholecystokinin (显示 CCK 蛋白)-(29-33)-amide in mouse brain is dependent on this enzyme: implications for the degradation and storage of peptides in classical late-infantile neuronal ceroid lipofuscinosis (显示 CLN6 蛋白) (tripeptidyl peptidase-I)
TPP-I is the predominant proteolytic enzyme responsible for the intracellular degradation of neuromedin B

蛋白简介TPP1

蛋白简介

This gene encodes a member of the sedolisin family of serine proteases. The protease functions in the lysosome to cleave N-terminal tripeptides from substrates, and has weaker endopeptidase activity. It is synthesized as a catalytically-inactive enzyme which is activated and auto-proteolyzed upon acidification. Mutations in this gene result in late-infantile neuronal ceroid lipofuscinosis, which is associated with the failure to degrade specific neuropeptides and a subunit of ATP synthase in the lysosome.

Alternative names and synonyms associated with TPP1

tripeptidyl peptidase I (tpp1)
tripeptidyl-peptidase 1 (NAEGRDRAFT_78259)
tripeptidyl-peptidase 1 (MCYG_00184)
tripeptidyl-peptidase 1 (MGYG_05881)
tripeptidyl-peptidase 1 (MGYG_00757)
tripeptidyl peptidase 1 (tpp1)
tripeptidyl peptidase 1 (TPP1)
tripeptidyl peptidase 1 (Tpp1)
tripeptidyl peptidase I (Tpp1)

Cln2 蛋白
fa01b09 蛋白
im:7149243 蛋白
LPIC 蛋白
TPP-1 蛋白
TPP-I 蛋白
wu:fa01b09 蛋白

Protein level used designations for Tripeptidyl Peptidase I 蛋白 (TPP1)

ceroid-lipofuscinosis, neuronal 2 , tripeptidyl-peptidase 1 , cell growth-inhibiting gene 1 protein , growth-inhibiting protein 1 , lysosomal pepstatin insensitive protease , tripeptidyl aminopeptidase , LPIC , TPP-1 , TPP-I , lysosomal pepstatin-insensitive protease , tripeptidyl peptidase 1 , tripeptidyl-peptidase I , tripeptidyl peptidase-I

GENE ID	SPECIES
798347	Danio rerio
8862382	Naegleria gruberi strain NEG-M
9230210	Arthroderma otae CBS 113480
10026584	Arthroderma gypseum CBS 118893
10031989	Arthroderma gypseum CBS 118893
100195058	Salmo salar
1200	Homo sapiens
485337	Canis lupus familiaris
515575	Bos taurus
83534	Rattus norvegicus
12751	Mus musculus
425576	Gallus gallus
100356773	Oryctolagus cuniculus
100733945	Cavia porcellus
450999	Pan troglodytes
100440001	Pongo abelii

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