Use your antibodies-online credentials, if available.
Deletion of the TFIIH kinase subunit Mat1 in mouse fibroblasts leads to dramatically reduced RNA polymerase II Ser5 phosphorylation.
investigated the function of the Cdk7 (显示 CDK7 蛋白).cyclin (显示 PCNA 蛋白) H.Mat1 complex in murine embryonic stem (ES) cells and preimplantation embryos to determine whether it regulates the unique cell cycle structure and transcriptional network of pluripotent cells
This study demonstrates a requirement for MAT1 in the operation of PGC-1 coactivators that control cell metabolism.
study found that Mat1 (显示 MAT1A 蛋白) and Cdk7 (显示 CDK7 蛋白) levels are undetectable in adipose tissues in vivo and downregulated during adipogenesis
Expressions of components of the CAK complex (显示 CCNH 蛋白), CDK7 (显示 CDK7 蛋白), MAT1 (显示 MAT1A 蛋白), and Cyclin H (显示 CCNH 蛋白) are elevated in breast cancer.
The intrinsically programmed MAT1 (显示 MAT1A 蛋白) expression and fragmentation regulate granulopoiesis.
The cyclin H (显示 CCNH 蛋白)/cdk7 (显示 CDK7 蛋白)/Mat1 (显示 MAT1A 蛋白) kinase activity is regulated by CK2 (显示 CSNK2A1 蛋白) phosphorylation of cyclin H (显示 CCNH 蛋白).
Retinoid-induced G1 arrest and differentiation activation are associated with a switch to enzyme hypophosphorylation of retinoic acid receptor alpha (显示 RARA 蛋白).
interaction with MTA1 (显示 MTA1 蛋白) and role in regulating estrogen receptor (显示 ESR1 蛋白) transactivation functions
In response to ATRA, PML (显示 PML 蛋白)/RARalpha (显示 RARA 蛋白) is dissociated from CAK (显示 CCNH 蛋白), leading to MAT1 (显示 MAT1A 蛋白) degradation, G1 arrest, and decreased CAK (显示 CCNH 蛋白) phosphorylation of PML (显示 PML 蛋白)/RARalpha (显示 RARA 蛋白)
Retinoic-acid-induced RAR (显示 RARA 蛋白)-CAK (显示 CCNH 蛋白) signaling events appear to proceed intrinsically during granulocytic development of normal primitive hematopoietic cells. ALDH-governed RA availability may mediate this process by initiating RAR (显示 RARA 蛋白)-CAK (显示 CCNH 蛋白) signaling.
These results suggested that genetic variants in CAK (显示 CCNH 蛋白) genes, Cdk7 (显示 CDK7 蛋白), cyclin H (显示 CCNH 蛋白), MAT1 (显示 MAT1A 蛋白), might modulate the risk of lung cancer in a gene-gene interaction mode, which consist to the biochemical interaction of corresponding proteins.
The protein encoded by this gene, along with cyclin H and CDK7, forms the CDK-activating kinase (CAK) enzymatic complex. This complex activates several cyclin-associated kinases and can also associate with TFIIH to activate transcription by RNA polymerase II. Two transcript variants encoding different isoforms have been found for this gene.
CDK-activating kinase assembly factor MAT1
, cdk-activating kinase assembly factor mat1
, CDK7/cyclin H assembly factor
, CDK7/cyclin-H assembly factor
, RING finger protein MAT1
, menage a trois 1
, RING finger protein 66
, cyclin G1 interacting protein
, cyclin-G1-interacting protein
, menage a trois 1 (CAK assembly factor)
, menage a trois homolog 1, cyclin H assembly factor