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Deletion of the TFIIH kinase subunit Mat1 in mouse fibroblasts leads to dramatically reduced RNA polymerase II Ser5 phosphorylation.
investigated the function of the Cdk7.cyclin H.Mat1 complex in murine embryonic stem (ES) cells and preimplantation embryos to determine whether it regulates the unique cell cycle structure and transcriptional network of pluripotent cells
This study demonstrates a requirement for MAT1 in the operation of PGC-1 coactivators that control cell metabolism.
study found that Mat1 and Cdk7 levels are undetectable in adipose tissues in vivo and downregulated during adipogenesis
MNAT1 binds to p53, mediates p53 ubiquitin-degradation through MDM2, increases cell growth and decreases cell apoptosis, and finally promotes CRC malignance.
Expressions of components of the CAK complex, CDK7, MAT1, and Cyclin H are elevated in breast cancer.
The intrinsically programmed MAT1 expression and fragmentation regulate granulopoiesis.
The cyclin H/cdk7/Mat1 kinase activity is regulated by CK2 phosphorylation of cyclin H.
Retinoid-induced G1 arrest and differentiation activation are associated with a switch to enzyme hypophosphorylation of retinoic acid receptor alpha.
interaction with MTA1 and role in regulating estrogen receptor transactivation functions
In response to ATRA, PML/RARalpha is dissociated from CAK, leading to MAT1 degradation, G1 arrest, and decreased CAK phosphorylation of PML/RARalpha
Retinoic-acid-induced RAR-CAK signaling events appear to proceed intrinsically during granulocytic development of normal primitive hematopoietic cells. ALDH-governed RA availability may mediate this process by initiating RAR-CAK signaling.
These results suggested that genetic variants in CAK genes, Cdk7, cyclin H, MAT1, might modulate the risk of lung cancer in a gene-gene interaction mode, which consist to the biochemical interaction of corresponding proteins.
The protein encoded by this gene, along with cyclin H and CDK7, forms the CDK-activating kinase (CAK) enzymatic complex. This complex activates several cyclin-associated kinases and can also associate with TFIIH to activate transcription by RNA polymerase II. Two transcript variants encoding different isoforms have been found for this gene.
CDK-activating kinase assembly factor MAT1
, cdk-activating kinase assembly factor mat1
, CDK7/cyclin H assembly factor
, CDK7/cyclin-H assembly factor
, RING finger protein MAT1
, menage a trois 1
, RING finger protein 66
, cyclin G1 interacting protein
, cyclin-G1-interacting protein
, menage a trois 1 (CAK assembly factor)
, menage a trois homolog 1, cyclin H assembly factor