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Hipk2 promotes PP1c-mediated Dvl (显示 DVL2 蛋白) dephosphorylation via its C-terminal domain and is essential Dvl (显示 DVL2 蛋白) stability.
Immunoprecipitation and pulldown experiments identified DCAF7 (显示 DCAF7 蛋白) as an adaptor for the association of the adenovirus E1A (显示 BCKDHA 蛋白) protein with DYRK1A (显示 DYRK1A 蛋白) and HIPK2
HIPK2 polymorphisms rs2058265, rs6464214, and rs7456421 may have a role in kidney stone disease in Chinese males
HIPK2 overexpression may be a potential prognostic marker for predicting prognoses and a high risk of recurrence, particularly in patients with HPV-positive Tonsillar squamous cell carcinomas.
Furthermore, our results suggest that modulation of either HIPK2 levels or activity could be exploited to impair NRF2 (显示 GABPA 蛋白)-mediated signalling in cancer cells, and thus sensitise them to chemotherapeutic drugs.
PARP1 (显示 PARP1 蛋白) can modulate the tumor-suppressing function of HIPK2 by regulating the protein stability of HIPK2.
Data show that HIPK2-T566 phosphorylation contributes to UV-induced HIPK2 activity but it is dispensable for doxorubicin response.
In this study, we report that the kinase HIPK2 is responsible for facilitating the Fbw7 (显示 FBXW7 蛋白)-dependent proteasomal degradation of Notch1 (显示 NOTCH1 蛋白) by phosphorylating its intracellular domain (Notch1 (显示 NOTCH1 蛋白)-IC) within the Cdc4 (显示 FBXW7 蛋白) phosphodegron motif.
the migration and invasion of hepatocellular carcinoma cells were impaired by knockdown of histone deacetylase 5 (显示 HDAC5 蛋白) or hypoxia-inducible factor-1alpha but rescued when eliminating homeodomain-interacting protein kinase-2 in hepatocellular carcinoma cells, which suggested the critical role of histone deacetylase 5 (显示 HDAC5 蛋白)-homeodomain-interacting protein kinase-2-hypoxia-inducible factor-1alpha pathway in hypoxia-induced metastasis.
These results suggest that the HIPK2-phospho-Ser271 CREB (显示 CREB1 蛋白) axis is a new arsenic-responsive CREB (显示 CREB1 蛋白) activation mechanism in parallel with the PKA-phospho-Ser133 CREB (显示 CREB1 蛋白) axis.
Results demonstrated that HIPK2 may function as a novel regulator to modulate hepatic stellate cells activation, potentially by inhibiting the TGF-beta1 (显示 TGFB1 蛋白)/Smad3 (显示 SMAD3 蛋白) signaling pathway.
Protein levels of HIPK2 were increased in high glucose or TGF-beta (显示 TGFB1 蛋白)-treated mouse glomerular mesangial cells. The HG- or TGF-beta (显示 TGFB1 蛋白)-induced upregulation of p-MeCP2, NOX4 (显示 NOX4 蛋白) and primary miR (显示 MLXIP 蛋白)-25, but downregulation of precursor and mature miR (显示 MLXIP 蛋白)-25, were attenuated by Hipk2 siRNA. The SIAH1 (显示 SIAH1 蛋白)/HIPK2/MeCP2 axis played a novel role for in suppressing miR (显示 MLXIP 蛋白)-25 processing and thereby upregulating NOX4 (显示 NOX4 蛋白) in early diabetic nephropathy.
reveal a previously unrecognized role of HIPK2 activation in ER-stress-mediated neurodegeneration and its potential role as a biomarker and therapeutic target for amyotrophic lateral sclerosis
Results indicate that Hipk2 exerts a relevant role in the survival of cerebellar Purkinje cells and that Hipk2 genetic ablation generates cerebellar dysfunction compatible with an ataxic-like phenotype.
HIPK2 is ubiquitinated upon heat shock.
Phosphorylation of KLF3 (显示 KLF3 蛋白) and CtBP2 (显示 CTBP2 蛋白) by HIPK2 strengthens the interaction between these two factors and increases transcriptional repression by KLF3 (显示 KLF3 蛋白).
Homeodomain-interacting protein kinase 2, a novel autoimmune regulator (显示 AIRE 蛋白) interaction partner, modulates promiscuous gene expression in medullary thymic epithelial cells.
Hipk2 has an essential role in mouse white fat development
data identify Hipk2 as a novel regulator of C/EBPbeta (显示 CEBPB 蛋白) and implicate different protein kinases in the cooperation of p300 (显示 NOTCH1 蛋白) with C/EBPbeta (显示 CEBPB 蛋白) and C/EBPalpha (显示 CEBPA 蛋白)
Data indicate a critical kinase HIPK2 function in cytokinesis and in the prevention of tetraploidization.
This gene encodes a conserved serine/threonine kinase that is a member of the homeodomain-interacting protein kinase family. The encoded protein interacts with homeodomain transcription factors and many other transcription factors such as p53, and can function as both a corepressor and a coactivator depending on the transcription factor and its subcellular localization. Multiple transcript variants encoding different isoforms have been found for this gene.
homeodomain interacting protein kinase 2
, serine/threonine protein kinase
, homeodomain-interacting protein kinase 2-like
, homeodomain-interacting protein kinase 2
, homeodomain-interacting protein kinase-2
, nuclear body-associated kinase 1
, sialophorin tail-associated nuclear serine/threonine-protein kinase
, Mx-interacting protein kinase PKM