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We identified recurrent mutations in the novel penile cancer tumor suppressor genes CSN1(GPS1) and FAT1
CSN1 appears to play a role not only in DNA repair but also in UV-induced apoptosis.
We analyzed whether CSN1 alone can increase DEN1 degradation in HeLa cells.these data suggest that the COP9 signalosome supports proteasome-dependent protein degradation of DEN1/DenA in fungi and in human cells.
An increased level of CSN1 and CSN5 as an important part of the ubiquitin proteasome system (UPS) might be associated with the pathophysiology of preeclampsia.
CSN1 inhibits c-Jun phosphorylation without affecting its protein stability.
The N-terminal half of CSN1/GPS1 is required to repress c-fos expression and to inhibit AP-1 and SRE transactivation, while the C-terminal half allows integration of the protein into the COP9 signalosome.
The present study demonstrates that Asb-4 interacts with GPS1 and inhibits JNK activity.
TSA1 interacts with CSN1 and is involved in Arabidopsis seedling development in darkness.
CSN1 can mediate COP1 nuclear translocation, and COP1 interacts with CSN1-NTD through its coiled-coil domain.
This gene is known to suppress G-protein and mitogen-activated signal transduction in mammalian cells. The encoded protein shares significant similarity with Arabidopsis FUS6, which is a regulator of light-mediated signal transduction in plant cells. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.
COP9 signalosome complex subunit 1
, COP9 signalosome subunit 1
, JAB1-containing signalosome subunit 1
, signalosome subunit 1
, G protein pathway suppressor 1
, MFH protein