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PAX5 (显示 PAX5 蛋白) was found to be an epigenetically inactivated tumor suppressor that inhibited non-small-cell lung proliferation and metastasis, through down-regulating the beta-catenin (显示 CTNNB1 蛋白) pathway and up-regulating GADD45G expression.
accumulation during myocardial infarction promotes the development and persistence of heart failure by inducing cardiomyocyte apoptosis in a p38 MAPK (显示 MAPK14 蛋白)-dependent manner
Results suggest the possibility that differential Gadd45a (显示 GADD45A 蛋白), Gadd45b (显示 GADD45B 蛋白) and Gadd45g expression during development affects neurons, contributing cortical evolution and diversity
The Gadd45g-d4Venus mice exhibited very similar labeling patterns in the ventricular zone (VZ), in Gadd45g-d4Venus mice cells could be visualized in more basal areas containing fully differentiated neurons.
Identify growth arrest and DNA-damage-inducible protein 45 (显示 GADD45A 蛋白) gamma (GADD45gamma) as a cold-induced activator of uncoupling protein 1 (UCP1 (显示 UCP1 蛋白)) and oxidative capacity in brown adipose tissue.
GADD45G functions as a negative regulator of the Jak (显示 JAK3 蛋白)-Stat3 (显示 STAT3 蛋白) pathway and inhibits hepatocellular carcinoma by inducing cellular senescence.
Gadd45g as a candidate gene for male infertility and 46,XY sex reversal in humans
suggest a requirement for GADD45gamma in promoting MAP3K4 (显示 MAP3K4 蛋白)-mediated activation of p38 MAPK (显示 MAPK14 蛋白) signaling in embryonic gonadal somatic cells for testis determination
suggest that a signaling cascade, involving GADD45G --> p38 MAPK (显示 MAPK14 蛋白) --> GATA4 (显示 GATA4 蛋白) --> SRY (显示 SRY 蛋白), regulates male sex determination
Gadd45a (显示 GADD45A 蛋白), Gadd45b (显示 GADD45B 蛋白) and Gadd45g expression during mouse embryonic development.
In an Eastern Chinese population, carriers of GADD45G rs8252T variant genotypes had a significantly lower risk of NSCLC. rs8252 variant CT/TT carriers showed significantly higher levels of GADD45G mRNA expression than CC carriers in the target tissues. There was some evidence of interactions between rs8252 genotypes and sex in NSCLC risk.
In addition to changes in MEK3 (显示 MAP2K3 蛋白) gene regulation, our study demonstrated upregulation of CACNG2 and GADD45G at the mRNA level in CMM patients.
In contrast to solid tumors, in DLBCL, the frequency of GADD45gamma methylation is higher and may be associated with progression. Nodal involvement is more likely to be present in patients with unmethylated GADD45gamma.
GADD45G protein, human
Results establish that the dowregulation of GADD45G-SIP1 (显示 GEMIN2 蛋白) axis may contribute to cellular senescence evasion and HCC (显示 FAM126A 蛋白) development.
we demonstrated that GADD45gamma expression in hepatocellular carcinoma cells was associated with sorafenib sensitivity
demonstrate for the first time that miR (显示 MLXIP 蛋白)-383 can specifically regulates the expression of Gadd45g by directly targeting to the 3-UTR region of Gadd45g mRNA, a regulatory process conserved in human tumor cells and mouse embryonic stem cells
Expression of GADD45gamma was significantly higher in pituitary adenomas of female patients.
Suggest that cucurbitacin E induced mitosis delay is regulated by GADD45gamma overexpression in malignant gliomas.
Here, the full-length cDNA sequence of porcine GADD45G gene was cloned through rapid amplification of cDNA ends (RACE) method.
This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The GADD45G is highly expressed in placenta.
, growth arrest and DNA damage 45 gamma
, growth arrest and DNA damage-inducible protein GADD45 gamma
, growth arrest and DNA-damage-inducible, gamma
, cytokine-responsive protein CR6
, growth arrest and DNA-damage-inducible protein GADD45 gamma
, DNA damage-inducible transcript 2 protein
, gadd-related protein, 17 kD
, growth arrest and DNA damage inducible
, growth arrest and DNA-damage-inducible 45 gamma
, growth arrest and DNA-damage-inducible gamma protein