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Among 479 individuals affected with clear cell renal cell carcinoma, only synonymous variants were found in COPS8 and one of the missense variants in ACKR3:c.892C>T, was observed in 4/479 individuals screened
Data indicate that silencing of Csn8 caused an increased growth rate, whereas silencing of Csn5 impaired proliferation in HeLa cells.
miR-146a expression is up-regulated in a majority of gastric cancers where it targets CARD10 and COPS8, inhibiting GPCR-mediated activation of NF-kappaB.
proteomic-based approach can broaden our understanding of the functions of the CSN in contexts such as viral-host interactions or immune activation in their natural milieu
analysis of the COP9 signalosome and its common architecture with the 26S proteasome lid and eIF3
DDB2 and CSA are each integrated into nearly identical complexes via interaction with DDB1. Both complexes contain cullin 4A and Roc1 and display ubiquitin ligase activity. They also contain the COP9 signalosome (CSN)
The COP9 signalosome (CSN) controls NF-kappaB by deubiquitinylation of IkappaBalpha.
COP9/signalosome increases the efficiency of von Hippel-Lindau protein ubiquitin ligase-mediated hypoxia-inducible factor-alpha ubiquitination
CSN8/CSN promotes the ubiquitination and degradation of misfolded proteins and protects against cardiac proteotoxicity, and cullin-RING ligases participate in degradation of cytosolic misfolded proteins.
Csn8 exerts profound impacts on hepatic ubiquitin-proteasome system function and is critical to the stability of the pro-apoptotic protein Bim.
CSN8/COP9 signalosome regulates both proteasome-mediated proteolysis and the autophagic-lysosomal pathway, critical to the removal of oxidized proteins in the heart.
Data indicate that a decreased level of Csn8 accelerated cell growth and shortened G1 duration.
Likely through regulating the expression of Rab7, Csn8/CSN plays a critical role in autophagosome maturation in myocardium.
The Csn8 is essential to the ability of mature hepatocytes to proliferate effectively in response to hepatic injury.
Csn8/CSN plays an essential role in cullin deneddylation, UPS-mediated degradation of a subset of proteins, and the survival of cardiomyocytes
involved in the transcriptional regulation of cell-specific gene expression
while constitutively photomorphogenic9 (COP9) signalosome (CSN) mutants can complete embryogenesis and are able to germinate, they progressively lose meristem activity upon germination until they become unable to sustain growth
This review provides an overview of the highly complex regulation of CULLIN-RING E3 ubiquitin ligase activity by COP9 signalosome (CSN), and the many roles of the CSN in plant development and defense.
SMAP1 interacts with the COP9 signalosome.
study concludes that the COP9 signalosome maintains a precise regulation of eIF3e levels, which is necessary for normal development in Arabidopsis
COP9 has a role in ethylene signaling.
COP9 signalosome- and 26S proteasome-dependent regulation of SCFTIR1 accumulation in Arabidopsis
Mutants in protein phosphatase type 2A (PP2A) also display reduced genome-wide H3 dephosphorylation, and sites of H3 phosphorylation that do not contain heat shock genes remain transcriptionally active during heat shock in PP2A mutants.
CSN8 is present exclusively as part of the CSN holo-complex, and lack of CSN8 in the mutants leads to CSN instability. Consistent with this, Cullin deneddylation is impaired in the csn8(null) mutants.
The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
COP9 constitutive photomorphogenic homolog subunit 8
, COP9 homolog
, COP9 signalosome complex subunit 8
, JAB1-containing signalosome subunit 8
, signalosome subunit 8
, COP9 (constitutive photomorphogenic) homolog, subunit 8
, COP9 signalosome subunit 8
, MGC80215 protein
, COP9 constitutive photomorphogenic homolog subunit 8 (Arabidopsis)
, Cop9 signalosome subunit 8
, drosophila COP9 signalosome homolog 8
, lethal (2) SH1829