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Study demonstrate that CDK7 activity is necessary to maintain the transcriptional program induced by STAT (显示 STAT1 蛋白) proteins that are activated both aberrantly by mutation and by extracellular cues in T-cell lymphomas.
these results implicate a CDK7-dependent "CTD code" that regulates chromatin marks in addition to RNA processing and pol II pausing.
Our studies have demonstrated the essential role of endogenous PRL (显示 PRL 蛋白) and CDK7 in the upregulation of PRLR (显示 PRLR 蛋白) by E2 and provide insights for therapeutic approaches that will mitigate the transcription/expression of PRLR (显示 PRLR 蛋白) and its participation in breast cancer progression fueled by E2 and PRL (显示 PRL 蛋白) via their cognate receptors.
Expressions of components of the CAK complex (显示 CCNH 蛋白), CDK7, MAT1 (显示 MAT1A 蛋白), and Cyclin H (显示 CCNH 蛋白) are elevated in breast cancer.
MYC (显示 MYC 蛋白) promotes mRNA cap methylation and protein production of Wnt (显示 WNT2 蛋白)/beta-catenin (显示 CTNNB1 蛋白) signaling transcripts through recruitment of cyclin-dependent kinase 7 (CDK7) and consequently RNMT to gene promoters.
High expression of MMP14 (显示 MMP14 蛋白) and CDK7 was independent prognostic factors for overall survival in patients with gastric cancer.
Taken together, these findings elucidated a novel mechanism of prostate cancer progression. Thus, SNHG1 might serve as a potential target for prostate cancer therapies.
Data indicate that cyclin dependent kinase 7 (CDK7) is overexpressed in gastric cancer cell lines and tissues.
Cdk7 broadly influences transcription and capping.
Our results indicated that CCNH (显示 CCNH 蛋白)/CDK7-CtBP2 (显示 CTBP2 蛋白) axis may augment ESCC cell migration, and targeting the interaction of both may provide a novel therapeutic target of esophageal squamous cell carcinoma .
the cyclin-dependent kinase (显示 CDK1 蛋白) CDK7 is regulated by miR (显示 MLXIP 蛋白)-210 and is necessary for normal NP cell-cycle progression. Our findings demonstrate that miRNAs are essential for normal NP proliferation and cell-cycle progress during neocortical development
Inhibition of CDK7 bypasses spindle assembly checkpoint via premature cyclin B degradation during oocyte meiosis.
Whereas Cdk7 was completely dispensable for global transcription, it was essential for the cell cycle via phosphorylation of Cdk1 (显示 CDK1 蛋白) and Cdk2 (显示 CDK2 蛋白). In vivo, Cdk7 was indispensable for cell proliferation except during the first stages of embryonic development.
investigated the function of the Cdk7.cyclin (显示 PCNA 蛋白) H.Mat1 complex in murine embryonic stem (ES) cells and preimplantation embryos to determine whether it regulates the unique cell cycle structure and transcriptional network of pluripotent cells
Cdk7 kinase activity and cell cycle kinetics were found to be comparable in wild-type and Hint(-/-) mouse embryonic fibroblasts, suggesting that Hint may not be a key regulator of Cdk7 activity
results demonstrate that the Cdk7 submodule of transcription factor IIH acts as a physiological roadblock to adipogenesis by inhibiting PPARgamma (显示 PPARG 蛋白) activity
Inhibition of SF-1 (显示 SF1 蛋白)-mediated transcription by SUMOylation in adrenocortical cancer cells is mediated through reduced CDK7-induced phosphorylation of SF-1 (显示 SF1 蛋白).
Mms19 (显示 MMS19 蛋白) is a mitotic gene that permits Cdk7 to be fully active as a Cdk-activating kinase.
Genetic and biochemical analyses reveal a functional interaction of MSL1 (显示 MSL1 蛋白) with CDK7, a subunit of the Cdk-activating kinase (CAK) complex (显示 CCNH 蛋白) of the general transcription factor TFIIH (显示 GTF2H5 蛋白). Importantly, MSL1 (显示 MSL1 蛋白) depletion leads to decreased phosphorylation of Ser5 of RNA polymerase II.
CDK7 is required for the mitochondrial localization of Hid and induction of apoptosis.
The multitask protein Xpd (显示 ERCC2 蛋白) also plays an essential role in cell cycle regulation that appears to be independent of transcription or nucleotide excision repair.
Cdk7 is required for full activation of Drosophila heat-shock genes and RNA polymerase II phosphorylation in vivo.
Analysis of Cdk7 expression in unfertilized eggs, embryos and organs of adult zebrafish suggests that Cdk7 message is maternally loaded; its transcript is detected throughout early embryonic development.
CDK7 and CCNH (显示 CCNH 蛋白) activate CDC2 (显示 CDK1 蛋白) by T161 phosphorylation and make up CDK-activating kinase, which is required for normal meiotic progression during porcine oocyte maturation.
The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This protein forms a trimeric complex with cyclin H and MAT1, which functions as a Cdk-activating kinase (CAK). It is an essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. This protein is thought to serve as a direct link between the regulation of transcription and the cell cycle.
39 KDa protein kinase
, CDK-activating kinase 1
, TFIIH basal transcription factor complex kinase subunit
, cell division protein kinase 7
, cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase)
, homolog of Xenopus MO15 Cdk-activating kinase
, kinase subunit of CAK
, p39 Mo15
, protein kinase
, serine/threonine kinase stk1
, serine/threonine protein kinase 1
, serine/threonine protein kinase MO15
, serine/threonine-protein kinase 1
, 39 kDa protein kinase
, CDK-activating kinase
, CR4 protein kinase
, CRK4 PK (CDC2-related-kinase-4 protein kinase)
, P39 Mo15
, cyclin-dependent kinase 7 (homolog of Xenopus MO15 cdk-activating kinase)
, protein-tyrosine kinase MPK-7
, 39 protein kinase
, cyclin-dependent kinase 7 (MO15 homolog Xenopus laevis cdk-activating kinase)
, 40 kDa protein kinase
, CDC2/CDK2,4-activating kinase
, P40 MO15
, cyclin-dependent kinase 7 (MO15, cdk-activating kinase)
, cell division protein kinase 7-like protein