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抗Human CDK1 抗体:
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Chicken Monoclonal CDK1 Primary Antibody for IHC (fro), IHC (p) - ABIN3043663
Ren, Huang, Xu, Yang, Yang, Hu: Isoflavone lupiwighteone induces cytotoxic, apoptotic, and antiangiogenic activities in DU-145 prostate cancer cells. in Anti-cancer drugs 2015
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Human Polyclonal CDK1 Primary Antibody for IHC (p), WB - ABIN3043473
Zheng, Liu, Liu, Ma, Zhou, Chen, Chang, Wang, Yang, He: Cucurbitacin B inhibits growth and induces apoptosis through the JAK2/STAT3 and MAPK pathways in SH?SY5Y human neuroblastoma cells. in Molecular medicine reports 2014
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Human Polyclonal CDK1 Primary Antibody for WB - ABIN3042681
Ye, Chen, Chen, Xie, Yang, Lou, Yu: XJW20, a novel oxoindole derivative, induces G2/M arrest and apoptosis selectively in K562 leukemia cell line. in Chemico-biological interactions 2009
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Human Monoclonal CDK1 Primary Antibody for WB - ABIN3043757
Lin, Fu, Zhao, Lin, Zou, Liu, Zhu, Wang, Yu: Fbxw8 is involved in the proliferation of human choriocarcinoma JEG-3 cells. in Molecular biology reports 2011
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Human Monoclonal CDK1 Primary Antibody for IHC (f), IF - ABIN967704
Barboule, Lafon, Chadebech, Vidal, Valette: Involvement of p21 in the PKC-induced regulation of the G2/M cell cycle transition. in FEBS letters 1999
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Human Monoclonal CDK1 Primary Antibody for IHC (f), IF - ABIN967705
García, Camacho, Morente, Fraga, Montalbán, Alvaro, Bellas, Castaño, Díez, Flores, Martin, Martinez, Mazorra, Menárguez, Mestre, Mollejo, Sáez, Sánchez, Piris: Hodgkin and Reed-Sternberg cells harbor alterations in the major tumor suppressor pathways and cell-cycle checkpoints: analyses using tissue microarrays. in Blood 2003
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Human CDK1 Primary Antibody for IHC - ABIN965827
Ukomadu, Dutta: Inhibition of cdk2 activating phosphorylation by mevastatin. in The Journal of biological chemistry 2003
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Human Polyclonal CDK1 Primary Antibody for IHC - ABIN965830
Morris, Gondeau, Tainer, Divita: Kinetic mechanism of activation of the Cdk2/cyclin A complex. Key role of the C-lobe of the Cdk. in The Journal of biological chemistry 2002
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Human Polyclonal CDK1 Primary Antibody for FACS, IF (p) - ABIN669891
Haolong, Du, Hongchao, Yang, Wei, Hua, Wenliang, Lei, Po: Enterovirus 71 VP1 activates calmodulin-dependent protein kinase II and results in the rearrangement of vimentin in human astrocyte cells. in PLoS ONE 2013
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Human Monoclonal CDK1 Primary Antibody for IF, IHC - ABIN965840
McMullin: The classification and diagnosis of erythrocytosis. in International journal of laboratory hematology 2008
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With tissue microarrays of hepatocellular carcinoma (HCC (显示 FAM126A 抗体)) patients, we determined the prognostic values of the core genes in the network and found that RAD21 (显示 RAD21 抗体), CDK1, and HDAC2 (显示 HDAC2 抗体) expression levels were negatively associated with overall survival for HCC (显示 FAM126A 抗体) patients. The multivariate Cox (显示 COX8A 抗体) regression analyses suggested that CDK1 was an independent prognostic factor, which was validated in an independent case cohort.
this study shows that CDK1 is a prognostic biomarker for lung adenocarcinoma
cytoplasmic Cdk1 expression is elevated in ovarian cancer and predicts a poor overall survival
findings demonstrate the involvement of consensus Cdk1 phosphorylation sites on Mis18 complex assembly and thus provide a rationale for cell cycle-regulated timing of Mis18 assembly and CENP-A (显示 CENPA 抗体) deposition
S130 of p21 (显示 CDKN1A 抗体) is phosphorylated by Cdk1/cyclin B1 (显示 CCNB1 抗体) during mitosis, which reduces p21 (显示 CDKN1A 抗体)'s stability and binding affinity to Cdk1/cyclin B1 (显示 CCNB1 抗体)
CDK9 (显示 CDK9 抗体), in addition to CDK1, has roles in mediating the growth inhibitory effect of dinaciclib on cyclin B1 (显示 CCNB1 抗体) in triple negative breast cancer
Findings suggest that mitotic CDK1-directed phosphorylation of delta-4E-BP1 (显示 EIF4EBP1 抗体) may yield a gain of function, distinct from translation regulation, that may be important in tumorigenesis and mitotic centrosome function.
The authors demonstrate that CDK1 controls Mis18 complex recruitment to centromeres by regulating oligomerization of M18BP1 (显示 MIS18BP1 抗体) through the Mis18alpha:Mis18beta scaffold.
These data show that complementary mechanisms, such as mother-daughter centriole proximity and CDK1-CyclinB (显示 CCNB1 抗体) interaction with centriolar components, ensure that centriole biogenesis occurs once and only once per cell cycle, raising parallels to the cell-cycle regulation of DNA replication and centromere formation.
Residual Cdk1/Cdk2 (显示 CDK2 抗体) activity after DNA damage promotes cell senescence.
our results show that the phosphorylation of 4E-BP1 (显示 EIF4EBP1 抗体) promotes translation at the onset of meiosis to support the spindle assembly and suggest an important role of CDK1 and mTOR (显示 FRAP1 抗体) kinases in this process
Study shows that Cdk1 phosphorylates Ska3 to promote its direct binding to the Ndc80 complex (Ndc80C), a core outer kinetochore component, also show that this phosphorylation occurs specifically during mitosis and is required for the kinetochore localization of the Ska complex.
loss of LAR (显示 PTPRF 抗体) activity resulted in reduced activity of CDK1.
CDK1 is a positive regulator of the IFN signaling pathway. The overexpression of CDK1 might contribute to the abnormally amplified type I IFN signaling in systemic lupus erythematosus.
Cdk1-induced desmin (显示 DES 抗体) phosphorylation is required for efficient separation of desmin (显示 DES 抗体)-IFs and generally detected in muscular mitotic cells in vivo.
using in vitro dephosphorylation assays, we demonstrate that Mastl (显示 MASTL 抗体) promotes persistent MPS1 phosphorylation by inhibiting PP2A (显示 PPP2R2B 抗体)/B55 (显示 MINK1 抗体)-mediated MPS1 dephosphorylation rather than affecting Cdk1 kinase activity. Our findings establish a key regulatory function of the Greatwall (显示 MASTL 抗体) kinase/Mastl (显示 MASTL 抗体) - PP2A (显示 PPP2R2B 抗体)/B55 (显示 MINK1 抗体) pathway in preventing premature SAC (显示 ADCY10 抗体) silencing
oxidative stress-induced (显示 SQSTM1 抗体) DNA damage of mouse zygotes triggers the cell cycle checkpoint, which results in G2/M cell cycle arrest, and that phospho-Cdc25B (显示 CDC25B 抗体) (Ser323), phospho-Cdc25C (显示 CDC25C 抗体) (Ser216), and phospho-Cdc2 (Tyr15) participate in activating the G2/M checkpoint.
CDK1 is required upstream of a checkpoint-associated cell death as well as meiotic metaphase progression in mouse spermatocytes.
CDK1 is a synthetic lethal target for KRAS mutant tumors.
Our data demonstrate that ES cells are uniquely sensitive to CDK1 inhibition via a p53 (显示 TP53 抗体)/NOXA (显示 PMAIP1 抗体)/MCL1 (显示 MCL1 抗体) pathway.
intestinal clock controls the expression of key cell cycle regulators, such as cdc2, wee1 (显示 WEE1 抗体), p21 (显示 CDKN1A 抗体), PCNA (显示 PCNA 抗体) and cdk2 (显示 CDK2 抗体), but only weakly influences cyclin B1 (显示 CCNB1 抗体), cyclin B2 (显示 CCNB2 抗体) and cyclin E1 (显示 CCNE1 抗体) expression.
Oligosaccharides of hyaluronan induce angiogenesis through distinct CD44 (显示 CD44 抗体) and RHAMM (显示 HMMR 抗体)-mediated signalling pathways involving Cdc2 and gamma-adducin (显示 ADD3 抗体).
Here the authors show that CPEB4 activity is regulated by ERK2- and Cdk1-mediated hyperphosphorylation. These phosphorylation events additively activate CPEB4 in M-phase by maintaining it in its monomeric state.
the fine-tuning of Cdc6 (显示 CDC6 抗体) accumulation is essential to ensure two meiotic waves of Cdk1 activation and to avoid unscheduled DNA replication during meiotic maturation.
equilibrium between CDK1 and PP2A (显示 PPP2R2B 抗体) specifies the timing of M-phase entry and exit and regulates the dynamics of cyclin B degradation upon M-phase exit in Xenopus laevis first embryonic mitosis.
CDK1 activation proceeds with concomitant inhibition by CDC6 (显示 CDC6 抗体), which tunes the timing of the M-phase entry during the embryonic cell cycle
Xenopus Cdk1-AS rescues HT2-19 cells from apoptosis.
Ras suppresses cyclin-dependent kinase 1 in a complex manner: It induces continuous accumulation of cyclin B2 (显示 CCNB2 抗体), but also causes persistent inhibitory phosphorylation of tyr (显示 TYR 抗体)-15-cyclin-dependent kinase 1.
Greatwall (显示 MASTL 抗体) kinase and cyclin B-Cdk1 are both critical constituents of M-phase-promoting factor.
By promoting CtIP (显示 RBBP8 抗体)-dependent resection of double-strand break (DSB) ends while preventing Rad51 chromatin assembly, Cdk1 inhibits both the nonhomologous and homologous modes of DSB repair during mitosis.
Examination of H1 histones reveals isoform-specific regulation by Cdk1 and RanGTP; mitotic Cdk1 functions to enhance H1 binding in egg extracts and embryos
Cdc2 displays cytoskeleton-dependent localization in blastomere cortex during Xenopus embryonic cell cycle.
Here the authors show that CDK1 phosphorylation of GNU negatively regulates PNG (显示 ETS2 抗体) kinase activity.
Cdk1 waves are not controlled by the mitotic switch but by a double-negative feedback between Cdk1 and Chk1 (显示 CHEK1 抗体). In Drosophila embryos, Cdk1 positive feedback serves primarily to ensure the rapid onset of mitosis, while wave propagation is regulated by S phase events.
Cdk1 phosphorylates the conserved centriole protein Sas-4 during mitosis. This creates a Polo (显示 PLK1 抗体)-docking site that helps recruit Polo (显示 PLK1 抗体) to daughter centrioles.
Our results indicate that the cyclic changes in Gwl (显示 MASTL 抗体) localization at mitotic entry and exit are directly regulated by the antagonistic cyclin B-Cdk1 and PP2A (显示 PPP2R2B 抗体)-Tws enzymes
Cdk1 mediates the role of TARA (显示 TRIOBP 抗体) and CycA (显示 CCNA2 抗体) in sleep regulation.
Y15 phosphorylation can both inhibit Cdk1 catalytic activity and de-stabilize Cdk1/Cyclin (显示 PCNA 抗体) complexes, whereas T161 phosphorylation facilitates stable interactions between cyclin B and Cdk1.
Phosphorylation of Cdk1 on Y15 appeared to be crucial for developmental and DNA damage-induced G2-phase checkpoint arrest, consistent with other evidence that Myt1 (显示 MYT1 抗体) is the major Y15-directed Cdk1 inhibitory kinase at this stage of development.
nonmuscle myosin II regulation by Cdc2 activity
CDK1 activation may be the cell cycle regulated event that determines the timing of emi1 destruction.
Data show that down-regulation of Cdc2 delayed pI mitosis and altered the polarity and the number of subsequent cell divisions.
CDK7 (显示 CDK7 抗体) and CCNH (显示 CCNH 抗体) activate CDC2 by T161 phosphorylation and make up CDK-activating kinase (显示 CDK7 抗体), which is required for normal meiotic progression during porcine oocyte maturation.
Results describe the expression of maternal cyclin B1 (显示 CCNB1 抗体) and Cdc2 during in vitro maturation of porcine oocytes.
Data demonstrate the presence of a novel structure in the cortex of porcine oocytes that comprises ERES and transiently accumulates CDC2 prior to germinal vesicle breakdown.
insufficient amount of Cdc2 and continuous activation of Wee1 B are the cause of meiotic failure of small oocytes in pigs
These results suggest that the inhibitory phosphorylation of CDC2, which is catalyzed by pigWee1B (显示 WEE2 抗体), but not pigMyt1, is involved in the meiotic arrest of porcine oocytes.
Data show that phosphatidylcholine (PC) biosynthesis is repressed by disruption of the core cell cycle regulator CYCLIN-DEPENDENT KINASE A;1 (CDKA;1) and that this repression is reliant on PHOSPHATIDIC ACID PHOSPHOHYDROLASE (PAH).
Cyclin-dependent kinase A (CDKA) phosphorylates eukaryotic initiation factor 4A (显示 DDX39 抗体) (eIF4A)eIF4A1 (显示 EIF4A1 抗体) and eIF4A2 (显示 EIF4A2 抗体) on a conserved threonine residue (threonine-164) within the RNA-binding motif.
CDKA;1 and CYCD3;2 are required for the terminal division in the stomatal lineage.
Data indicate that the in vivo confirmation of substrates of CDKA;1 showing a direct link between cell proliferation and the control of the redox state.
The crucial function of CDKA;1 is the control of the plant Retinoblastoma homolog RBR1 and codepletion of RBR1 and CDKA;1 rescued most defects of cdka;1 mutants.
Expression of a dominant negative CDKA;1 allele under the control of the STM (显示 SHMT1 抗体) promoter perturbs post-embryonic development. Inhibition of CDK (显示 CDK4 抗体) activity at the shoot apex (显示 APEX1 抗体) results in premature differentiation of shoot apical meristem cells.
When a single cdka;1 sperm was delivered, either female gamete could be fertilized leading to similar proportions of seeds containing either a single endosperm or a single embryo.
However, we show here that the DNA damage checkpoint in Arabidopsis can also operate independently of the phosphorylation of CDKA;1.
CDC2A participates in the fertilization process of endosperm
The balance between cell division and differentiation is regulated through the interaction between CDKA;1 and the antiphosphatase PAS2. [CDKA;1]
These results reveal a crucial and conserved role of phosphorylation of the N terminus of Bora for Plk1 (显示 PLK1 抗体) activation and mitotic entry.
CDK-1 regulates PLK-1 (显示 PLK1 抗体) activity during mitosis in C. elegans embryos through multisite phosphorylation of the PLK-1 (显示 PLK1 抗体) activator SPAT (显示 AGXT 抗体)-1
Conversion of microtubule-organizing center state involves the conserved C. elegans centrosome protein SPD-2/CEP192 and cell-cycle-dependent kinase activity from the mitotic cell.
Our results support a model in which CYB (显示 CSTB 抗体)-2.1/2/CDK-1 antagonize CUL-2 (显示 CUL2 抗体) activity to promote stabilization of PAR-6 (显示 PARD6A 抗体) levels during polarization of the early C. elegans embryo.
CDK-1 activates PLK-1 (显示 PLK1 抗体) via SPAT (显示 AGXT 抗体)-1 phosphorylation to promote entry into mitosis.
model in which Wnt signaling and CDK-1 modify WRM-1 in a temporal and spatial manner to unmask an intrinsic polarity cue required for proper orientation of the endomesoderm cell division axis
results indicate that CDC-25.1 is required for maintaining proper rate of germline mitotic cell cycle; propose that CDC-25.1 regulates the rate of germline mitotic cell cycle by counteracting WEE (显示 WEE1 抗体)-1.3 and by positively controlling CDK-1
CDK-1 blocks rotation by inhibiting dynein association with microtubules.
Use of loss- and gain-of-function genetic approaches demonstrates that CYY-1, a cyclin (显示 PCNA 抗体) box-containing protein, drives synapse removal in this process.
NPP-16 and CDK-1 function to arrest prophase blastomeres in C. elegans embryos
The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
cell cycle controller CDC2
, cell division control protein 2 homolog
, cell division cycle 2, G1 to S and G2 to M
, cell division protein kinase 1
, p34 protein kinase
, cyclin-dependent kinase 1
, cell cycle p34 CDC2 kinase protein
, cell division cycle 2 homolog A
, cell division cycle control protein 2a
, Cell division cycle control protein 2
, cell division cycle 2
, Cell division control protein 2 homolog 1
, cell division control protein 2-A
, cell division cycle 2 like
, cell division protein kinase 1-A
, cyclin-dependent kinase 1-A
, p34 protein kinase 1
, cdc2 kinase
, cyclin dependent kinase
, cyclin-dependent kinase
, cell division cycle 2 protein
, protein cdc2 kinase
, putative cyclin-dependent kinase A family protein
, cell division control protein 2 homolog 2
, cell division control protein 2-B
, cell division protein kinase 1-B
, cyclin-dependent kinase 1-B
, p34 protein kinase 2
, DNA polymerase delta
, DNA-directed DNA polymerase delta 1
, polymerase (DNA directed), delta 1, catalytic subunit 125kDa
, Cell division control protein 2 homolog
, Cell division protein kinase 1
, Cell division control protein 2