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BRCA1 抗体

(Breast Cancer 1 (BRCA1))
This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified. [provided by RefSeq, May 2009].
BRCA1 抗体  (AA 120-220) BRCA1 抗体  (AA 120-220) BRCA1 抗体 (AA 120-220) (ABIN1512646)

BRCA1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated

BRCA1 抗体  (AA 19-83) BRCA1 抗体  (AA 19-83) BRCA1 抗体 (AA 19-83) (ABIN7433579)

BRCA1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

BRCA1 抗体  (pSer1423) BRCA1 抗体  (pSer1423) BRCA1 抗体 (pSer1423) (ABIN7265138)

BRCA1 适用: 人, 大鼠, 小鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

BRCA1 抗体 by Grade

Find BRCA1 抗体 with a specific Grade. The Grade listed below are among those available. Click on a link to go to the corresponding products.

BRCA1 抗体 by 适用

Find BRCA1 抗体 for a variety of species such as anti-Human BRCA1, anti-Rat BRCA1, anti-Mouse BRCA1. The species listed below are among those available. Click on a link to go to the corresponding products.

BRCA1 抗体 by 应用范围

Find BRCA1 抗体 validated for a specific application such as WB, ELISA, IF, IF (p). Some of the available applications are listed below. Click on a link to go to the corresponding products.

BRCA1 抗体 by 抗体来源

Find BRCA1 抗体 with a specific 抗体来源. The 抗体来源 listed below are among those available. Click on a link to go to the corresponding products.

BRCA1 抗体 by 抗原表位

Find BRCA1 抗体 with a specific epitope. The epitopes listed below are among those available. Click on a link to go to the corresponding products.

BRCA1 抗体 by 克隆形成能力

Find available monoclonal or polyclonal BRCA1 抗体. Click on a link to go to the corresponding products.

BRCA1 抗体 by 克隆

Find BRCA1 抗体 with a specific 克隆. The 克隆 listed below are among those available. Click on a link to go to the corresponding products.

BRCA1 抗体 by 标记

Find BRCA1 抗体 with a specific conjugate such as Biotin, FITC, Alexa Fluor 488. The conjugates listed below are among those available. Click on a link to go to the corresponding products.

Popular BRCA1 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IHC
Validations
  • (2)
  • (9)
Cat. No. ABIN1512646
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, IHC, IP, ICC
Validations
  • (6)
Cat. No. ABIN7433579
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, IHC, IF
Validations
  • (7)
Cat. No. ABIN7265138
Quantity 200 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC, ELISA
Validations
  • (1)
  • (5)
Cat. No. ABIN1724848
Quantity 0.1 mg
Datasheet Datasheet
Reactivity Human
Application WB, IF
Validations
  • (4)
Cat. No. ABIN6137644
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, IHC (p)
Validations
  • (2)
  • (4)
Cat. No. ABIN3044313
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Rat
Application WB, ELISA, IF, IHC (p)
Validations
  • (3)
Cat. No. ABIN7251052
Quantity 200 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC, ELISA
Validations
  • (3)
Cat. No. ABIN3183542
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Rat
Application WB, IHC, ELISA, IF
Validations
  • (3)
Cat. No. ABIN3183543
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application IHC, ISt, StM
Validations
  • (3)
Cat. No. ABIN6940661
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, IF, IP
Validations
  • (3)
  • (2)
Cat. No. ABIN534087
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IF, IP, ICC
Validations
  • (2)
  • (2)
Cat. No. ABIN534086
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC, IF
Validations
  • (3)
Cat. No. ABIN7265923
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IF, IP, FACS, ICC
Validations
  • (4)
Cat. No. ABIN363234
Quantity 0.1 mL
Datasheet Datasheet
Reactivity Mouse, Rat
Application ELISA, IHC (p), FACS, IF (p), IF (cc), IHC (fro)
Validations
  • (1)
  • (1)
Cat. No. ABIN728368
Quantity 100 μL
Datasheet Datasheet

Latest Publications for our BRCA1 抗体

Bodo, Campagne, Thin, Higginson, Vargas, Hua, Fuller, Ackerstaff, Russell, Zhang, Klingler, Cho, Kaag, Mazaheri, Rimner, Manova-Todorova, Epel, Zatcky, Cleary, Rao, Yamada, Zelefsky, Halpern et al.: "Single-dose radiotherapy disables tumor cell homologous recombination via ischemia/reperfusion injury. ..." in: The Journal of clinical investigation, Vol. 129, Issue 2, pp. 786-801, (2019) (PubMed).

Yin, Liu, Peng, Peng, Yu, Gao, Yuan, Zhu, Cao, He, Gong, Sun, Fan, Li: "PARP inhibitor veliparib and HDAC inhibitor SAHA synergistically co-target the UHRF1/BRCA1 DNA damage repair complex in prostate cancer cells." in: Journal of experimental & clinical cancer research : CR, Vol. 37, Issue 1, pp. 153, (2018) (PubMed).

Penn, Yang, Zong, Lim, Cole, Yang, Baker, Goonewardena, Buckanovich: "Therapeutic Impact of Nanoparticle Therapy Targeting Tumor-Associated Macrophages." in: Molecular cancer therapeutics, Vol. 17, Issue 1, pp. 96-106, (2018) (PubMed).

Zhai, Steinø, Bacha, Brown, Daugaard: "Dianhydrogalactitol induces replication-dependent DNA damage in tumor cells preferentially resolved by homologous recombination." in: Cell death & disease, Vol. 9, Issue 10, pp. 1016, (2018) (PubMed).

Liu, Lai, Li, Sun, Cheng, Ge, Wang, Li, Zhang, De Felici, Dyce, Shen: "Di (2-ethylhexyl) phthalate exposure impairs meiotic progression and DNA damage repair in fetal mouse oocytes in vitro." in: Cell death & disease, Vol. 8, Issue 8, pp. e2966, (2017) (PubMed).

Wang, He, Wu, Li, Gao, Zeng: "Artemisinin mimics calorie restriction to trigger mitochondrial biogenesis and compromise telomere shortening in mice." in: PeerJ, Vol. 3, pp. e822, (2015) (PubMed).

Ntokou, Klein, Dontireddy, Becker, Bellusci, Richardson, Szibor, Braun, Morty, Seeger, Voswinckel, Ahlbrecht: "Characterization of the platelet-derived growth factor receptor-α-positive cell lineage during murine late lung development." in: American journal of physiology. Lung cellular and molecular physiology, Vol. 309, Issue 9, pp. L942-58, (2015) (PubMed).

Martin, Nakamura, Paila, Woo, Brown, Wright, Teraoka, Haghayegh, McCurdy, Schneider, Hu, Quinlan, Gatti, Concannon: "Homozygous mutation of MTPAP causes cellular radiosensitivity and persistent DNA double-strand breaks." in: Cell death & disease, Vol. 5, pp. e1130, (2014) (PubMed).

Rosen, Leung, Louie, Cordeiro, Conroy, Shapira, Fields, Cesano, Hawtin: "Quantitative measurement of alterations in DNA damage repair (DDR) pathways using single cell network profiling (SCNP)." in: Journal of translational medicine, Vol. 12, pp. 184, (2014) (PubMed).

Milner, Wombwell, Eckersley, Barnes, Warwicker, Van Dorp, Rowlinson, Dearden, Hughes, Harbron, Wellings, Hodgson, Womack, Gray, Lau, OConnor, Marsden, Kvist: "Validation of the BRCA1 antibody MS110 and the utility of BRCA1 as a patient selection biomarker in immunohistochemical analysis of breast and ovarian tumours." in: Virchows Archiv : an international journal of pathology, Vol. 462, Issue 3, pp. 269-79, (2013) (PubMed).

Aliases for BRCA1 抗体

BRCA1, DNA repair associated (BRCA1) 抗体
breast cancer 1 (brca1) 抗体
breast cancer 1, early onset (LOC755086) 抗体
breast cancer 1, early onset (Brca1) 抗体
BRCA1, DNA repair associated (Brca1) 抗体
breast cancer 1, early onset (BRCA1) 抗体
breast cancer 1 L homeolog (brca1.L) 抗体
brca1 抗体
BRCA1 抗体
BRCAI 抗体
brcai 抗体
BRCC1 抗体
brcc1 抗体
BROVCA1 抗体
IRIS 抗体
iris 抗体
LOC100224649 抗体
PNCA4 抗体
PPP1R53 抗体
PSCP 抗体
pscp 抗体
RNF53 抗体
rnf53 抗体
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