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Human Polyclonal RAB13 Primary Antibody for ICC, IF - ABIN4348882
Abou-Zeid, Pandjaitan, Sengmanivong, David, Le Pavec, Salamero, Zahraoui: MICAL-like1 mediates epidermal growth factor receptor endocytosis. in Molecular biology of the cell 2011
Rab13 activated the downstream AMPK (显示 PRKAA1 抗体) and blocked mTOR (显示 FRAP1 抗体) signaling by its functional interaction with Grb2 (显示 GRB2 抗体) to regulate autophagy in human vascular endothelial cells.
Inactive Rab13 appears to associate with vesicles via protein-protein interactions. Only following activation does Rab13 associate with the plasma membrane, presumably with insertion of the C-terminal prenyl group into the membrane.
the role of Rab13 as a potent driver of cancer progression.
Rab8A (显示 RAB8A 抗体) GTPase (显示 RACGAP1 抗体) Ser (显示 SIGLEC1 抗体)(111) phosphorylation is not directly regulated by PINK1 (显示 PINK1 抗体) in vitro and demonstrate in cells the time course of Ser (显示 SIGLEC1 抗体)(111) phosphorylation of Rab8A (显示 RAB8A 抗体), 8B and 13 is markedly delayed compared to phosphorylation of Parkin (显示 PARK2 抗体) at Ser (显示 SIGLEC1 抗体)(65).
Disruption of Rab13-mediated trafficking dramatically limits the invasive behavior of epithelial cells in vitro and the growth and migration of highly invasive cancer cells in vivo.
It is suggested that Rab13 is associated with a putative secretory function in osteoclasts.
Rab13,VASP (显示 VASP 抗体),and ZO-1 (显示 TJP1 抗体) were found in apical tight junctions in normal epithelium but were dislocated to the basolateral position in patients with inactive Crohn's disease. In patients with ulcerative colitis,these tight junction proteins were not dislocated.
Rab13 specifically mediates the continuous endocytic recycling of occludin (显示 OCLN 抗体) to the cell surface in both fibroblastic and epithelial cells
Rab13 regulates membrane trafficking between the trans-Golgi network (TGN (显示 TG 抗体)) and recycling endosomes (RE).
Rab13 acts with Mst1 (显示 MST1 抗体) to regulate the spatial distribution of LFA-1 (显示 ITGAL 抗体) and the motility and trafficking of lymphocytes
Rab13 associates with Grb2 (显示 GRB2 抗体), targeting Syx (显示 PLEKHG5 抗体) and RhoA (显示 RHOA 抗体) to Tyr (显示 TYR 抗体)(1175)-phosphorylated VEGFR2 (显示 KDR 抗体) at the leading edge.
Rab13 and Rab8A (显示 RAB8A 抗体) are Rab (显示 HRB 抗体)-GTPases activated by insulin (显示 INS 抗体) and downstream of AS160 (显示 TBC1D4 抗体) they regulate traffic of GLUT4 (显示 SLC2A4 抗体) vesicles.
This gene is a member of the Rab family of small G proteins and plays a role in regulating membrane trafficking between trans-Golgi network (TGN) and recycling endosomes (RE). The encoded protein is involved in the assembly of tight junctions, which are components of the apical junctional complex (AJC) of epithelial cells. The AJC plays a role in forming a barrier between luminal contents and the underlying tissue. Additional functions associated with the protein include endocytic recycling of occludin, regulation of epithelial cell scattering, neuronal regeneration and regulation of neurite outgrowth. Alternately spliced transcript variants have been observed for this gene. A pseudogene associated with this gene is located on chromosome 12.
ras-related protein Rab-13
, RAB13, member RAS oncogene family
, RAS-associated protein RAB13
, cell growth-inhibiting gene 4 protein
, growth-inhibiting gene 4 protein