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抗Human RAB13 抗体:
抗Mouse (Murine) RAB13 抗体:
抗Rat (Rattus) RAB13 抗体:
Human Polyclonal RAB13 Primary Antibody for ICC, IF - ABIN4348882
Abou-Zeid, Pandjaitan, Sengmanivong, David, Le Pavec, Salamero, Zahraoui: MICAL-like1 mediates epidermal growth factor receptor endocytosis. in Molecular biology of the cell 2011
Rab13 activated the downstream AMPK and blocked mTOR signaling by its functional interaction with Grb2 to regulate autophagy in human vascular endothelial cells.
Inactive Rab13 appears to associate with vesicles via protein-protein interactions. Only following activation does Rab13 associate with the plasma membrane, presumably with insertion of the C-terminal prenyl group into the membrane.
the role of Rab13 as a potent driver of cancer progression.
Rab8A GTPase Ser(111) phosphorylation is not directly regulated by PINK1 in vitro and demonstrate in cells the time course of Ser(111) phosphorylation of Rab8A, 8B and 13 is markedly delayed compared to phosphorylation of Parkin at Ser(65).
Disruption of Rab13-mediated trafficking dramatically limits the invasive behavior of epithelial cells in vitro and the growth and migration of highly invasive cancer cells in vivo.
It is suggested that Rab13 is associated with a putative secretory function in osteoclasts.
Rab13,VASP,and ZO-1 were found in apical tight junctions in normal epithelium but were dislocated to the basolateral position in patients with inactive Crohn's disease. In patients with ulcerative colitis,these tight junction proteins were not dislocated.
Rab13 specifically mediates the continuous endocytic recycling of occludin to the cell surface in both fibroblastic and epithelial cells
Involved in epithelial cell scattering.
Rab13 regulates membrane trafficking between the trans-Golgi network (TGN) and recycling endosomes (RE).
Rab13 acts with Mst1 to regulate the spatial distribution of LFA-1 and the motility and trafficking of lymphocytes
Rab13 associates with Grb2, targeting Syx and RhoA to Tyr(1175)-phosphorylated VEGFR2 at the leading edge.
Rab13 and Rab8A are Rab-GTPases activated by insulin and downstream of AS160 they regulate traffic of GLUT4 vesicles.
This gene is a member of the Rab family of small G proteins and plays a role in regulating membrane trafficking between trans-Golgi network (TGN) and recycling endosomes (RE). The encoded protein is involved in the assembly of tight junctions, which are components of the apical junctional complex (AJC) of epithelial cells. The AJC plays a role in forming a barrier between luminal contents and the underlying tissue. Additional functions associated with the protein include endocytic recycling of occludin, regulation of epithelial cell scattering, neuronal regeneration and regulation of neurite outgrowth. Alternately spliced transcript variants have been observed for this gene. A pseudogene associated with this gene is located on chromosome 12.
ras-related protein Rab-13
, RAB13, member RAS oncogene family
, RAS-associated protein RAB13
, cell growth-inhibiting gene 4 protein
, growth-inhibiting gene 4 protein