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抗Human HEG1 抗体:
抗Mouse (Murine) HEG1 抗体:
抗Rat (Rattus) HEG1 抗体:
Zebrafish (Danio rerio) Polyclonal HEG1 Primary Antibody for WB - ABIN1881407
Mably, Mohideen, Burns, Chen, Fishman: heart of glass regulates the concentric growth of the heart in zebrafish. in Current biology : CB 2003
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These studies establish that the binding of HEG1 to Rasip1 (显示 RASIP1 抗体) mediates Rap1 (显示 RABGEF1 抗体)-dependent recruitment of Rasip1 (显示 RASIP1 抗体) to and stabilization of endothelial cell cell-cell junctions.
Human patients with cerebral cavernous malformations who lack exonic mutations in krev (显示 RAP1B 抗体) interaction trapped protein (KRIT)1 (显示 KRIT1 抗体), cerebral cavernous malformation (CCM) protein 2, or programmed cell death (PDCD)10 (显示 PDCD10 抗体) protein do not have mutations in HEG.
These data show that HEG1 can recruit the Rap1-KRIT complex to the plasma membrane.
Identification of the zebrafish heart of glass (heg) gene. Description of HEG's role in the regulation of concentric heart growth in zebrafish.
Defects in the hearts of zebrafish lacking heg or ccm2 (显示 CCM2 抗体), in the aortas of early mouse embryos lacking CCM2 (显示 CCM2 抗体) and in the lymphatic vessels of neonatal mice lacking HEG1 were associated with abnormal endothelial cell junctions like those observed in human CCMs
Receptor component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity May act through the stabilization of endothelial cell junctions (By similarity).
HEG homolog 1
, heart of glass
, protein HEG homolog 1