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Human LGALS1 Protein expressed in Escherichia coli (E. coli) - ABIN2002512
Nishi, Abe, Iwaki, Yoshida, Itoh, Shoji, Kamitori, Hirabayashi, Nakamura: Functional and structural bases of a cysteine-less mutant as a long-lasting substitute for galectin-1. in Glycobiology 2008
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High LGALS1 expression is associated with fibrosis in chronic pancreatitis and pancreatic cancer.
Pancreatic stellate cells promote cancer proliferation, migration, and invasion via Gal1-driven pathways. Gene-expression analyses of pancreatic tumor cells exposed to Gal1 reveal modulation of multiple regulatory pathways involved in tumor progression.
Studies indicate tumor-derived galectin-1, galectin-3 (显示 LGALS3 蛋白) and galectin-9 (显示 LGALS9 蛋白) in various cancers and anticancer therapies that target these molecules [Review].
The expression level of galectin-1 affects survival in patients with glioblastoma multiforme treated with adjuvant radiotherapy
Results show that Galectin-1 teams up with Galectin-3 (显示 LGALS3 蛋白) to induce inflammatory/pro-degradative gene signature in human chondrocytes affecting the progression of osteoarthritis. Also, Galectin-3 (显示 LGALS3 蛋白) was found to induce a pro-degradative-inflammatory gene signature in human chondrocytes, teaming up with Galectin-1 in the pathogenesis of osteoarthritis.
We also found a subset of prostate cancer patient-derived xenografts and prostate cancer patient samples with mild HO-1 (显示 HMOX1 蛋白) and low Gal-1 expression levels. These results highlight a novel function of a human-used drug as a means of boosting the antitumor response
Gal-1, Gal-3 (显示 LGALS3 蛋白) and Gal-9 (显示 LGALS9 蛋白) galectin expression was higher in the myenteric plexus ganglia of chagasic patients
Results have shown that Gal-1 in the farnesyl-bound form acquires the ability to form self-clusters, and the galactoside-binding pocket of Gal-1 in the FTS (显示 AKTIP 蛋白)-bound form plays an important role in self-cluster formation.
Our findings support the introduction of galectin-1 as a reliable diagnostic marker for thyroid carcinomas. Its involvement in cell proliferation, migration, invasion and tumor growth also intimate functional involvement of galectin-1 in the progression of thyroid carcinoma, suggesting its potential as a therapeutic target
This study showed that obese children had significantly higher galectin-1 levels in proportion to fat mass in obese cases than those in healthy children, which may be interpreted as a compensatory increase in an attempt to improve glucose metabolism.
Gal-1 may serve as an adhesion molecule (显示 NCAM1 蛋白) to interact with both cells and laminins
Gal-1 is expressed in a wide range of porcine tissues, including striated (显示 NSDHL 蛋白) muscle, liver, lung, brain, kidney, spleen, and intestine
LGALS1 was found widely expressed in all tissues and transient transfection indicated that galectin-1 locates both in cytoplasm and nucleus.
Data suggest that galectin-1 and VEGFR-2 (显示 KDR 蛋白) are expressed at mid-luteal stages in luteal cells of corpus luteum; galectin-1 binds directly to asparagine-linked glycans (N-glycans) on VEGFR-2 (显示 KDR 蛋白) in luteal cells.
The relative abundance of PIBF (显示 PIBF1 蛋白), LGALS1, LGALS3 (显示 LGALS2 蛋白), LGALS3BP (显示 LGALS3BP 蛋白), and LGALS9 (显示 LGALS9 蛋白) mRNA would display a differential expression pattern in the endometrium.
The binding affinity and specificity of galectin-1 for eight different beta-galactosyl terminal disaccharides was studied using molecular-dynamics simulations.
Overexpression of galectin-1 inhibited the proliferation of T-cells by means of HSC (显示 FUT1 蛋白) activation, which reduced the inflammatory response by exerting immunosuppressive effects and furthermore enhanced immune tolerance and alleviated hepatic fibrosis in liver transplantation.
Gal-1 is a major driver of pancreatic cancer progression. Genetic deletion of Gal1 in a Kras-driven mouse model of pancreatic ductal adenocarcinoma results in a significant increase in survival through mechanisms involving decreased stroma activation, attenuated vascularization, and enhanced T cell infiltration leading to diminished metastasis rates.
This work identified Gal1, an endogenous immune regulatory lectin, as an integral component of the secretory granule machinery and unveil the unexpected function of this lectin in regulating CTL killing activity.
The results of this study showed that development of spinal axons as well as the locomotor abilities observed in adult mice are independent of Gal-1.
GAL-1 also enhanced the generation of neural crest cells from explanted neural tubes
this present study indicated that Gal-1 secreted from MSCs upregulated expression of Gal-1 and stimulated formation of tolerance immunophenotype on DCs, where the underlying mechanism was the regulation of the MAPK (显示 MAPK1 蛋白) signaling pathway in DCs, thereby inhibiting the function of DCs
markedly increased brain Gal-1 and S-nitrosylated Gal-1 both in scrapie-infected rodents and human prion (显示 PRNP 蛋白) diseases.
Gal-1 can limit eosinophil recruitment to allergic airways and suppresses airway inflammation by inhibiting cell migration and promoting eosinophil apoptosis.
Gal1 protein is essential for efficient liver regeneration following partial hepatectomy through the regulation of liver inflammation, hepatic cell proliferation, and the control of lipid storage in the regenerating liver.
findings show that galectin-1 (Gal-1), an immunoregulatory lectin widely expressed in mucosal tissues, contributes to Y. enterocolitica pathogenicity by undermining protective antibacterial responses.
Equine bone marrow mesenchymal stromal cells constitutively express high levels of galectin-1 mRNA relative to other articular cell types, suggesting a possible mechanism for their intra-articular immunomodulatory properties.
The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. This gene product may act as an autocrine negative growth factor that regulates cell proliferation.
14 kDa laminin-binding protein
, 14 kDa lectin
, S-Lac lectin 1
, beta-galactoside-binding lectin L-14-I
, beta-galactoside-binding protein 14kDa
, galectin 1
, lactose-binding lectin 1
, putative MAPK-activating protein PM12
, lectin galactoside-binding soluble 1
, beta-galactoside-binding lectin
, RL 14.5
, lectin, galactose binding, soluble 1
, lectin, galactoside-binding, soluble, 1 (galectin 1)
, 14K beta-galactoside-binding lectin
, galectin CG-1B
, lectin, galactoside-binding, soluble, 1
, beta-galactoside binding protein
, Beta-galactoside-binding lectin L-14-I
, Lactose-binding lectin 1
, Lectin galactoside-binding soluble 1