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抗Human GCKR 抗体:
抗Rat (Rattus) GCKR 抗体:
抗Mouse (Murine) GCKR 抗体:
Mouse (Murine) Polyclonal GCKR Primary Antibody for ELISA, WB - ABIN451749
Kathiresan, Melander, Guiducci, Surti, Burtt, Rieder, Cooper, Roos, Voight, Havulinna, Wahlstrand, Hedner, Corella, Tai, Ordovas, Berglund, Vartiainen, Jousilahti, Hedblad, Taskinen, Newton-Cheh et al.: Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans. ... in Nature genetics 2008
Show all 2 Pubmed References
genome-wide association study in US: Data suggest, among white subjects, an SNP in RCN3 (rs34459162) and a missense mutation in GCKR (rs1260236) are associated with serum levels of glycated albumin; among black subjects, an intergenic SNP in PRKCA (rs2438321) is associated with fructosamine levels and an intronic variant in PRKCA (rs59443763) is associated with glycated albumin levels. (RCN3 = reticulocalbin-3)
Interaction of any alcohol exposure with GCKR (rs780094) and A1CF (显示 A1CF 抗体) (rs10821905) influenced the risk of gout in Europeans
GCKR rs780094-C is associated with increased risk of gestational diabetes mellitus.[meta-analysis]
Mutations in the genes glucokinase regulatory protein (GCKR), RNase L (RNASEL (显示 RNASEL 抗体)), leukocyte immunoglobulin-like receptor 3 (显示 LILRB3 抗体) (LILRA3 (显示 LILRA3 抗体)), and dynein axonemal heavy chain 10 (DNAH10 (显示 DNAH10 抗体)) segregated with elevated HDLc levels in families, while no mutations associated with low HDLc.
Three loci showed robust, replicating association with circulating FXI (显示 F11 抗体) levels: KNG1 (显示 KNG1 抗体) (rs710446, P-value = 2.07 x 10-302), F11 (显示 F11 抗体) (rs4253417, P-value = 2.86 x 10-193), and a novel association in GCKR (rs780094, P-value = 3.56 x10-09), here for the first time implicated in FXI (显示 F11 抗体) regulation. The two first SNPs (rs710446 and rs4253417) also associated with partial thromboplastin (显示 F3 抗体) time
GCKR association with adiposity and the risk of the nonalcoholic fatty liver disease
The existence of a liver-specific FOXA2 (显示 FOXA2 抗体)-regulated transcriptional enhancer at an intronic T2D locus represented by rs780094, rs780095, and rs780096 SNPs that increases GCKR expression is demonstrated.
GCKR Leu446 may influence FGF21 (显示 FGF21 抗体) expression via its ability to increase glucokinase (GCK (显示 GCK 抗体)) activity. This can lead to enhanced FGF21 (显示 FGF21 抗体) expression via elevated fatty acid synthesis, consequent to the inhibition of carnitine/palmitoyl-transferase by malonyl-CoA, and via increased glucose-6-phosphate-mediated activation of the carbohydrate response element binding protein (显示 MLXIPL 抗体), known to regulate FGF21 (显示 FGF21 抗体) gene expression.
Data suggest that hepatic glucokinase (显示 GCK 抗体) activity is regulated by reversible binding to specific inhibitor protein glucokinase regulatory protein (GKRP) and by binding to activator proteins such as 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase (PFK2 (显示 PFKFB3 抗体)/FBP2 (显示 KHSRP 抗体)); changes in glucokinase (显示 GCK 抗体) expression and activity are associated with poorly controlled type 2 diabetes and nonalcoholic fatty liver disease. [REVIEW]
The rs780094 [1.34 (1.21-1.49); p = 8.57 x 10(-8) ] on chr 2 at the glucokinase regulatory protein (GCKR) locus was similarly significantly associated, while the rs10911205 [1.29 (1.16-1.44); p = 3.52 x 10(-6) ] on chr1 at the laminin subunit gamma-1 (LAMC1 (显示 LAMC1 抗体)) locus showed suggestive association with disease.
This study showed that Sirt2 (显示 SIRT2 抗体)-dependent GKRP deacetylation improves impaired HGU and suggest that it may be a therapeutic target for type 2 diabetes.
Given that acetylated GKRP may affiliate with type-2 diabetes mellitus (T2DM), understanding the mechanism of GKRP acetylation in the liver could reveal novel targets within the GK-GKRP pathway, for treating T2DM and other metabolic pathologies.
Germinal center kinase-related (显示 MAP4K5 抗体) enzyme (GCKR) facilitates both canonical and noncanonical Wnt (显示 WNT2 抗体) signaling in B lymphocytes.
Glucokinase regulatory protein binds to a super-open conformation of GK mainly through hydrophobic interaction, inhibiting the GK activity by locking a small domain of GK.
This gene encodes a protein belonging to the GCKR subfamily of the SIS (Sugar ISomerase) family of proteins. The gene product is a regulatory protein that inhibits glucokinase in liver and pancreatic islet cells by binding non-covalently to form an inactive complex with the enzyme. This gene is considered a susceptibility gene candidate for a form of maturity-onset diabetes of the young (MODY).
glucokinase regulatory protein
, glucokinase regulator
, MAPK/ERK kinase kinase kinase 5
, MEK kinase kinase 5
, MEKKK 5
, LOW QUALITY PROTEIN: glucokinase regulatory protein
, glucokinase (hexokinase 4) regulator