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Human CRP Protein expressed in HEK-293 Cells - ABIN2487343
Meyer, Ueland: Targeted quantification of C-reactive protein and cystatin c and its variants by immuno-MALDI-MS. in Analytical chemistry 2014
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Circulating pentraxin nCRP has little pro-angiogenic effect but when dissociated into mCRP on the surface of endothelial cells it is able to trigger potent proangiogenic effects by inducing F3-gene upregulation and TF signaling.
High baseline serum consentrations of IL-6 (显示 IL6 蛋白) or CRP were associated with impaired prognosis in mCRC. IL-6 (显示 IL6 蛋白) and CRP give independent prognostic information in addition to RAS and BRAF (显示 BRAF 蛋白) mutation status.
Up-regulation of IL-8 (显示 IL8 蛋白) and its association with the marker of clinical and inflammatory activity, CRP, suggest a role of this cytokine in the pathogenesis of chronic spontaneous urticaria.
The present findings suggest that high circulating CRP is predictive of major cardiovascular events in peripheral artery disease patients (Review and Meta-Analysis).
High CRP expression is associated with hepatocellular carcinoma and liver cirrhosis.
C-reactive protein/albumin (显示 ALB 蛋白) ratio (CAR), an inflammation-based prognostic score, is a potential independent predictor for disease progression and death in patients with operable non-small cell lung cancer.
The levels of alpha enolase IgG antibodies correlated with the number of oral ulcers, erythrocyte sedimentation rate, and CRP levels.
Review/Meta-analysis: circulating levels of CRP, IL-6 (显示 IL6 蛋白) and TNF-alpha (显示 TNF 蛋白) might be not useful biomarkers for identifying colorectal adenoma risk.
association of high-sensitivity C-reactive protein and hypertension was consistent across menopausal stages and was independent of body mass index in premenopausal but not in perimenopausal or postmenopausal women
Study showed that high levels of C-reactive protein (CRP) were induced and correlated with complement activation in patients infected with severe influenza A (H5N1, H7N9 or H10N8), and higher levels were induced in fatal patients than in survivors. These results propose that CRP is involved in deterioration of severe influenza diseases.
FcgammaRIIb and FcgammaRIII are involved in the CRP-induced expression of MMPs and TIMP-1 and the CRP-induced phosphorylation of p38, whereas the FcgammaR-independent pathway may regulate the CRP-induced MMP-11 expression and the CRP-induced ERK1/2 phosphorylation.
C-reactive protein may promote acute kidney injury by impairing tubular epithelial cell regeneration via the CD32-Smad3 (显示 SMAD3 蛋白)-p27 (显示 CDKN1B 蛋白)-driven inhibition of the CDK2 (显示 CDK2 蛋白)/cyclin E (显示 CCNE1 蛋白) complex.
These results suggested that CRP/oxidized low density lipoprotein/beta 2-Glycoprotein I (显示 APOH 蛋白) complexes may induce lipid accumulation and inflammation in macrophages via the p38/MAPK (显示 MAPK14 蛋白) and NFkappaB signaling pathways.
these data unexpectedly identify CBS (显示 CBS 蛋白) as the major recognition site of mCRP and suggest that this motif may be exploited to tune the proinflammatory actions of mCRP.
CRP decreased adiponectin expression and multimerization, while CRP-induced decline in adiponectin might be mediated through the PI3K/Akt (显示 AKT1 蛋白) pathway.
Effects of C-Reactive Protein on the Cardiac Differentiation of Mouse Embryonic Stem Cells
These data indicated that CRP may have a direct role on osteoclast and osteoblast differentiation via toll (显示 TLR4 蛋白)-like receptor signaling pathways.
Data suggest that serum amyloid P (SAP (显示 APCS 蛋白)) activates CD209 DC-SIGN (显示 CD209 蛋白) to regulate the innate immune system differently from C-reactive protein (CRP), and that DC-SIGN (显示 CD209 蛋白) is a target for antifibrotics.
the acute phase protein (显示 ORM1 蛋白) C (显示 PROC 蛋白)-reactive protein (CRP), a ligand for Fc receptors on phagocytes, enhances antibody-mediated platelet destruction by phagocytes in vivo
CRP has therapeutic potential against cancer through decreasing the accumulation of M2 macrophages and angiogenesis within tumors.
data show, for the first time, a significant increase of c-reactive protein (CRP) in the blood of calves 1 d after colostrum intake.
Enhanced external counterpulsation decreased C-reactive protein and increased flow-mediated dilation in hypercholesterolemia.
serum C-reactive protein correlates with macrophage accumulation and coronary artery disease in hypercholesterolemic pigs
CRP inhibits endothelium-dependent NO-mediated dilation in coronary arterioles by producing superoxide from NAD(P)H (显示 NQO1 蛋白) oxidase via p38 (显示 MAPK14 蛋白) kinase activation.
The present study shows that elevated levels of serum CRP and IL-10 (显示 IL10 蛋白) were associated with porcine circovirus type 2-infected piglets that subsequently developed severe PMWS. (postweaning multisystemic wasting syndrome)
These data suggest that CRP might play a pathogenic role in the development of myointimal hyperplasia in polytetrafluoroethylene grafts.
myocardial infarction induced proinflammatory gene and protein expression in peripheral blood mononuclear cells of tissue factor (显示 F3 蛋白) cyclo-oxygenase-2, monocyte chemoattractant protein-1 (显示 CCL2 蛋白) and CRP
CRP stimulates superoxide production and the subsequent formation of peroxynitrite from basal released nitric oxide compromises PGI(2 (显示 PTGIR 蛋白)) synthesis.
Data show that during posttranplant obliterative bronchiolitis development, CRP is localized in inflammatory cells, myofibroblasts and endothelial cells probably as a part of the local inflammatory response.
Rabbit CRP acute-phase system binds phosphocholine and phosphoethanolamine.
IL-6 (显示 IL6 蛋白) augments mechanical strain-induced CRP synthesis in vessels via the stretch-activated channel-NF-kappaB (显示 NFKB1 蛋白) pathway.
CRP antagonism of eNOS (显示 NOS3 蛋白) is mediated by coupling of FcgammaRI (显示 FCGR1A 蛋白) to FcgammaRIIB by Src kinase (显示 CSK 蛋白) and activation of inositol 5'-phosphatase 1, and consistent with this mechanism, both FcgammaRI (显示 FCGR1A 蛋白) and FcgammaRIIB are required for CRP to blunt endothelial repair in vivo.
Metformin attenuated the progression of aortic atherosclerosis via down-regulation of serum C-reactive protein.
The protein encoded by this gene belongs to the pentaxin family. It is involved in several host defense related functions based on its ability to recognize foreign pathogens and damaged cells of the host and to initiate their elimination by interacting with humoral and cellular effector systems in the blood. Consequently, the level of this protein in plasma increases greatly during acute phase response to tissue injury, infection, or other inflammatory stimuli.
, pentraxin 1
, C-reactive protein, petaxin related
, C-reactive protein member of the pentraxin family
, C-reactive protein, member of the pentraxin family
, amyloid P component, serum
, serum amyloid P component
, LIM only protein HLP
, cysteine-rich protein 2
, heart LIM protein
, contiguous repeat polypeptide
, glutamine/glutamic acid-rich protein B
, submandibular gland secretory Glx-rich protein CB