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Human AGER Protein expressed in HEK-293 Cells - ABIN2180572
Xue, Rai, Singer, Chabierski, Xie, Reverdatto, Burz, Schmidt, Hoffmann, Shekhtman: Advanced glycation end product recognition by the receptor for AGEs. in Structure (London, England : 1993) 2011
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Human AGER Protein expressed in Human Cells - ABIN2004453
Sugaya, Fukagawa, Matsumoto, Mita, Takahashi, Ando, Inoko, Ikemura et al.: Three genes in the human MHC class III region near the junction with the class II: gene for receptor of advanced glycosylation end products, PBX2 homeobox gene and a notch homolog, human counterpart ... in Genomics 1995
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Results show that RAGE is activated by HMGB1 (显示 HMGB1 蛋白) to induce EMT (显示 ITK 蛋白) in prostate cancer cells.
high mobility group box 1 (显示 HMGB1 蛋白)-receptor for advanced glycation end-products (HMGB1 (显示 HMGB1 蛋白)-RAGE) signaling pathway may be involved in the pathogenesis of preterm premature rupture of the membranes (pPROM (显示 SERPINH1 蛋白)).
Results show that RAGE is upregulated in breast cancer tissues, and confirmed that RAGE was a direct target of miR (显示 MLXIP 蛋白)-328.
The results suggest that S100A12 (显示 S100A12 蛋白) does not participate in the induction of inflammation in dental pulp. However, RAGE can participate in the inflammation in the pulp of males.
The results show for the first time that RAGE is present in neuronally-derived plasma exosomes, and suggest that exosomal RAGE may be a novel biomarker that reflects pathophysiological processes in the brain.
Decreased soluble RAGE in neutrophilic asthma is correlated with disease severity and RAGE G82S variants.
Our study provides novel evidence for a potential role of AGER in bridging human papillomavirus (HPV)-induced inflammation and cervical cancer.
Plasmatic RAGE level is significantly lower in patients with prosthetic-joint-associated infections.
Inhibition of GLO1 (显示 GLO1 蛋白) in Glioblastoma Multiforme Increases DNA-AGEs, Stimulates RAGE Expression, and Inhibits Brain Tumor Growth in Orthotopic Mouse Models
a significant association between RAGE gene rs1800624 and rs1800625 polymorphisms and Age-related macular degeneration risk, is reported.
Established a murine model of myocardial ischemia-reperfusion injury; investigated and found remote ischemic postconditioning protects against IR injury thru RAGE-HMGB1 (显示 HMGB1 蛋白) Pathway.
In this study, we found that the wnt (显示 WNT2 蛋白) co-receptor Lrp6 (显示 LRP6 蛋白) was a potent positive regulator of beta-catenin (显示 CTNNB1 蛋白) signaling in TDI-induced asthma models, both in vivo and in vitro. Additionally, for the first time, we demonstrated that RAGE could mediate phosphorylation of Lrp6 (显示 LRP6 蛋白), suggesting a functional cross talk between RAGE and the canonical wnt (显示 WNT2 蛋白)/beta-catenin (显示 CTNNB1 蛋白) signaling pathway involved in mediating beta-catenin (显示 CTNNB1 蛋白) activation.
Chronic unpredictable stress (CUS) promotes significant morphological changes and causes robust upregulation of HMGB1 (显示 HMGB1 蛋白) messenger RNA in enriched hippocampal microglia and robust and persistent upregulation of RAGE messenger RNA. CUS increased surface expression of RAGE protein on hippocampal microglia and anhedonic behavior. RAGE knockout mice were resilient to stress-induced anhedonia.
study found that diabetes predisposes to more severe infections because of additional inflammatory output through dual activation of MyD88 (显示 MYD88 蛋白) by not only TLR4 (显示 TLR4 蛋白) but also RAGE
RAGE controls myocardial dysfunction and oxidative stress in high-fat fed mice by sustaining mitochondrial dynamics and autophagy-lysosome pathway.
these data provide a previously uncharacterized in vivo mechanism contingent on oligodeoxy-nucleotide -administered dose, where TLR9 (显示 TLR9 蛋白) governs the primary response and RAGE plays a distinct and cooperative function in providing a pivotal role in balancing the immune response.
data demonstrate that under the diabetic condition, DRG neurons are directly affected by elevated levels of glucose, independent of vascular or glial signals, and dependent on RAGE expression.
findings suggest that HMGB1 (显示 HMGB1 蛋白) induces the transcytosis of albumin (显示 ALB 蛋白) via RAGE-dependent Src (显示 SRC 蛋白) phosphorylation and Cav-1 (显示 CAV1 蛋白) phosphorylation. These studies revealed a new mechanism of HMGB1 (显示 HMGB1 蛋白)-induced endothelial hyperpermeability.
data suggest that S100A8 (显示 S100A8 蛋白)/A9 acts directly on BV-2 microglial cells via binding to TLR4 (显示 TLR4 蛋白) and RAGE on the membrane and then stimulates the secretion of proinflammatory cytokines through ERK (显示 EPHB2 蛋白) and JNK (显示 MAPK8 蛋白)-mediated NF-kappaB (显示 NFKB1 蛋白) activity in BV-2 microglial cells.
Activation of RAGE facilitates the development of hypoxia-induced pulmonary hypertension by increasing ECM (显示 MMRN1 蛋白) deposition in pulmonary arteries.
Our results suggested that the increased RAGE expression in inflammatory circumstances and interaction with AGEs are risk factors in decreasing of aggrecan (显示 ACAN 蛋白) content in nucleus pulposus.
The advanced glycosylation end product (AGE) receptor encoded by this gene is a member of the immunoglobulin superfamily of cell surface receptors. It is a multiligand receptor, and besides AGE, interacts with other molecules implicated in homeostasis, development, and inflammation, and certain diseases, such as diabetes and Alzheimer's disease. Many alternatively spliced transcript variants encoding different isoforms, as well as non-protein-coding variants, have been described for this gene (PMID:18089847).
RAGE isoform NtRAGE-delta
, RAGE isoform sRAGE-delta
, advanced glycation end-products receptor
, receptor for advanced glycosylation end products
, advanced glycosylation end product-specific receptor variant 2
, advanced glycosylation end product-specific receptor variant 3
, advanced glycosylation end product-specific receptor variant 4
, advanced glycosylation end product-specific receptor variant 5
, advanced glycosylation end product-specific receptor variant 1
, advanced glycosylation end product-specific receptor variant 6
, advanced glycosylation end product-specific receptor variant 7
, advanced glycosylation end product-specific receptor variant 8
, advanced glycation end product receptor
, advanced glycosylation end product-specific receptor
, MAPK/MAK/MRK overlapping kinase
, renal tumor antigen