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Rat (Rattus) Polyclonal AGER Primary Antibody for FACS, IF (p) - ABIN725900
Huang, Yao, Zhang, Dong, Yu, Sheng: The effect of high-mobility group box 1 protein on activity of regulatory T cells after thermal injury in rats. in Shock (Augusta, Ga.) 2009
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Human Polyclonal AGER Primary Antibody for IHC (p), WB - ABIN3043529
Qin, Niu, Wang, Xu, Qiao, Gu: Heparanase induced by advanced glycation end products (AGEs) promotes macrophage migration involving RAGE and PI3K/AKT pathway. in Cardiovascular diabetology 2013
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Human Polyclonal AGER Primary Antibody for IHC (fro), IHC (p) - ABIN3044329
Wang, Zhang, Liu, Cui, Yang, Li, Du: Tanshinone II A down-regulates HMGB1, RAGE, TLR4, NF-kappaB expression, ameliorates BBB permeability and endothelial cell function, and protects rat brains against focal ischemia. in Brain research 2010
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Human Polyclonal AGER Primary Antibody for IF (p), IHC (p) - ABIN1386239
Durning, Preston-Hurlburt, Clark, Xu, Herold: The Receptor for Advanced Glycation Endproducts Drives T Cell Survival and Inflammation in Type 1 Diabetes Mellitus. in Journal of immunology (Baltimore, Md. : 1950) 2016
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Rat (Rattus) Polyclonal AGER Primary Antibody for FACS, IF (p) - ABIN725907
Zhu, Yao, Zhang, Dong, Yu, Sheng: Anti-RAGE antibody ameliorates severe thermal injury in rats through regulating cellular immune function. in Acta pharmacologica Sinica 2014
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Cow (Bovine) Polyclonal AGER Primary Antibody for WB - ABIN2786877
Luo, Saiardi, Nagata, Ye, Yu, Jung, Luo, Jain, Sawa, Snyder: GRAB: a physiologic guanine nucleotide exchange factor for Rab3A, which interacts with inositol hexakisphosphate kinase. in Neuron 2001
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Human Polyclonal AGER Primary Antibody for ICC, IF - ABIN4349231
Zhu, Ito, Nakahara, Nagae, Fuyuno, Nakao, Akahoshi, Nakagawa, Tu, Uchi, Furue: Upregulation of S100P, receptor for advanced glycation end products and ezrin in malignant melanoma. in The Journal of dermatology 2013
Mouse (Murine) Polyclonal AGER Primary Antibody for IHC (p), WB - ABIN4349236
Yue, Zhou, Zhu, Rao, Busuttil, Kupiec-Weglinski, Lu, Zhai: Hyperglycemia and liver ischemia reperfusion injury: a role for the advanced glycation endproduct and its receptor pathway. in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2015
Human Polyclonal AGER Primary Antibody for ELISA, WB - ABIN1573995
Milutinovic, Alcorn, Englert, Crum, Oury: The receptor for advanced glycation end products is a central mediator of asthma pathogenesis. in The American journal of pathology 2012
Human Polyclonal AGER Primary Antibody for IHC, ELISA - ABIN1585839
Patche, Girard, Catan, Boyer, Dobi, Planesse, Diotel, Guerin-Dubourg, Baret, Bravo, Paradela-Dobarro, Álvarez, Essop, Meilhac, Bourdon, Rondeau: Diabetes-induced hepatic oxidative stress: a new pathogenic role for glycated albumin. in Free radical biology & medicine 2017
High RAGE expression is associated with lung cancer.
findings collectively demonstrate that fasting blood sRAGE and esRAGE may be causally implicated in IGM in primary hypertensive patients
Our data suggest that the inhibition of sRAGE on I/R-induced apoptosis is associated with activation and expression of proteasome, including improved proteasome activity and elevated beta1i (显示 PSMB9 抗体) and beta5i expression mediated by STAT3 (显示 STAT3 抗体) activation. We predict that sRAGE is a novel intervention to target UPS activation for preventing and treating myocardial apoptosis.
Receptor for AGE expression and reactive oxygen species production were upregulated in db/db (显示 LEPR 抗体) mouse livers, together with impaired proteolytic, antioxidant and mitochondrial respiratory activities. In parallel, acute exposure of HepG2 cells to glycated albumin (显示 ALB 抗体) also elicited intracellular free radical formation
Our data suggest that H2S reduces RAGE dimer formation and impairs its membrane stability. The lowered plasma membrane abundance of RAGE therefore helps to protect cells against various RAGE mediated pathological effects.
results imply that the interaction of matrix AGEs with RAGE plays a role in the TGFbeta2-mediated EMT (显示 ITK 抗体) of lens epithelial cells and suggest that the blockade of RAGE could be a strategy to prevent PCO and other age-associated fibrosis.
novel findings suggest that HMGB1 (显示 HMGB1 抗体) triggered EPC (显示 TCF21 抗体) apoptosis in a manner of RAGE-mediated activation of the PERK (显示 EIF2AK3 抗体)/eIF2alpha (显示 EIF2A 抗体) pathway.
Activation of RAGE by AGEs causes up regulation of the transcription factor nuclear factor-kappaB and its target genes. of the RAGE engagement stimulates oxidative stress, evokes inflammatory and fibrotic reactions, which all contribute to the development and progression of devastating cardiovascular disorders.
The lowering of glycative stress via modulation of RAGE-AGE axis or glyoxalase 1 (显示 GLO1 抗体) activity is beneficial for tubular homeostasis and the subsequent prevention and treatment of kidney disease, suggesting the possibility of novel therapeutic approaches which target glycative stress.
HMGB1 (显示 HMGB1 抗体) attenuates TGF-beta (显示 TGFB1 抗体)-induced epithelial-mesenchymal transition of FaDu hypopharyngeal carcinoma cells through regulation of RAGE expression
Our results suggested that the increased RAGE expression in inflammatory circumstances and interaction with AGEs are risk factors in decreasing of aggrecan (显示 ACAN 抗体) content in nucleus pulposus.
We investigated the role of RAGE in postischaemic leukocyte adhesion after myocardial infarction and its effect on postischaemic myocardial function. RAGE represents an additional pro-inflammatory endothelial mediator of ischaemia-reperfusion injury.
The results indicate that cells respond to advanced glycation end products by increasing matrix assembly and that RAGE is involved in this response.
RAGE is phosphorylated by the ATM (显示 ATM 抗体) kinase and is recruited to the site of DNA-double-strand break via an early DNA damage response.
receptor for advanced glycation end products (RAGE) was required for stabilization of beta-catenin (显示 CTNNB1 抗体) in toluene diisocyanate-induced asthma, identifying protective effects of RAGE blockade in this mouse model
perturbation of Bone marrow mesenchymal stromal cells in diabetes mellitus could be partially explained by chronic RAGE signaling.
RAGE mediates inflammation that contributes to lung damage, in cigarette smoke-induced lung pathology.
Ager deletion enhances ischemic muscle inflammation, angiogenesis, and blood flow recovery in diabetic mice.
HMGB1 (显示 HMGB1 抗体) neither exerts influence on cardiac remodeling by binding to RAGE nor induces apoptosis of cardiomyocytes under physiological condition
Our results indicate that lack of RAGE has no significant impact on septic arthritis. However, RAGE-/- mice had significantly higher BMD (显示 BEST1 抗体) compared to WT mice, which coincided with lower IL-17A (显示 IL17A 抗体) in RAGE-/- mice. In sepsis, RAGE deficiency impairs bacterial kidney clearance.
The advanced glycosylation end product (AGE) receptor encoded by this gene is a member of the immunoglobulin superfamily of cell surface receptors. It is a multiligand receptor, and besides AGE, interacts with other molecules implicated in homeostasis, development, and inflammation, and certain diseases, such as diabetes and Alzheimer's disease. Many alternatively spliced transcript variants encoding different isoforms, as well as non-protein-coding variants, have been described for this gene (PMID:18089847).
advanced glycosylation end product-specific receptor
, RAGE isoform NtRAGE-delta
, RAGE isoform sRAGE-delta
, advanced glycation end product receptor
, advanced glycosylation end product-specific receptor variant 1
, advanced glycosylation end product-specific receptor variant 3
, advanced glycosylation end product-specific receptor variant 4
, advanced glycosylation end product-specific receptor variant 5
, advanced glycosylation end product-specific receptor variant 6
, advanced glycosylation end product-specific receptor variant 7
, advanced glycosylation end product-specific receptor variant 8
, receptor for advanced glycosylation end products
, advanced glycation end-products receptor
, advanced glycosylation end product-specific receptor variant 2