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Study found a protective effect of PACAP-38 (显示 ADCYAP1 ELISA试剂盒) on oxidative stress damage in zebrafish hair cells, suggesting PACAP-38 (显示 ADCYAP1 ELISA试剂盒) ability to prevent hair cells from apoptosis. PACAP-38 (显示 ADCYAP1 ELISA试剂盒) treatment decreased the cleaved caspase-3 (显示 CASP3 ELISA试剂盒) level in the hair cells, but somewhat unexpectedly had no influence on p-38 MAPK (显示 MAPK1 ELISA试剂盒) pathway. PACAP-38 (显示 ADCYAP1 ELISA试剂盒) treatment also rescued H2O2-induced reduction in movement.
PACAP might play dual roles in regulating follicle growth and maturation through different receptors located in different compartments.
These results suggest that, in fish, PACAP and PAC1-R may play a role in brain development.
The temporal and spatial expression pattern of the ghrh-pacap1 (显示 ADCYAP1 ELISA试剂盒) transcript suggests that these hormones may modulate patterning during development.
zfPACAP38-2 is a potential ovarian factor that mediates gonadotropin actions in paracrine/autocrine manners, and its functional roles are likely, to some extent, related to the ovarian activin (显示 Actbeta ELISA试剂盒)/follistatin (显示 FST ELISA试剂盒) system.
Splice variants of pVPAC1-R are predominantly expressed in all tissues instead of the transcript encoding the full-length receptor, hinting that pVPAC2-R may play more important roles than pVPAC1-R in mediating VIP (显示 Vip ELISA试剂盒) and PACAP (显示 ADCYAP1 ELISA试剂盒) actions.
The 'CC' genotype of the VIPR2 gene was nominally associated with an increased risk of SCZ in male Han Chinese patients.
In vitro-polarized macrophages by GM-CSF (显示 CSF2 ELISA试剂盒) (GM-MO), with a proinflammatory profile, expressed higher levels of VIP (显示 Vip ELISA试剂盒) receptors, vasoactive intestinal polypeptide (显示 Vip ELISA试剂盒) receptors 1 and 2 (VPAC1 (显示 VIPR1 ELISA试剂盒) and VPAC2, respectively), than macrophages polarized by M-CSF (显示 CSF1 ELISA试剂盒) (M-MO) with anti-inflammatory activities. RA synovial macrophages, according to their GM-CSF (显示 CSF2 ELISA试剂盒)-like polarization state, expressed both VPAC1 (显示 VIPR1 ELISA试剂盒) and VPAC2.
Lower CpG methylation of VIPR2 in the saliva (显示 RAG1AP1 ELISA试剂盒) of children with ADHD.
The results reveal that more severe inflammation, based on high levels of IL-6 (显示 IL6 ELISA试剂盒), is associated with lower expression of VPAC1 (显示 VIPR1 ELISA试剂盒) and, conversely, with increased expression of VPAC2.
CD4 (显示 CD4 ELISA试剂盒)+ T cells in HIV infection show increased levels of expression of VPAC2
This study suggest that carriers of microduplication genotypes of VIPR2 are predisposed to SCZ in Han Chinese.
Monocytes from Sjogren's syndrome patients display increased vasoactive intestinal peptide receptor 2 expression and impaired apoptotic cell phagocytosis.
Data indicate that VIP (显示 Vip ELISA试剂盒) and PACAP (显示 ADCYAP1 ELISA试剂盒) increased macrophage resistance to HIV-1 replication by inducing the synthesis of beta-chemokines CCL3 (显示 CCL3 ELISA试剂盒) and CCL5 (显示 CCL5 ELISA试剂盒) and IL-10 (显示 IL10 ELISA试剂盒) following preferential activation of the receptors VPAC2 and PAC1 (显示 ADCYAP1R1 ELISA试剂盒).
This is the first study to suggest a role of VIPR2 in the genetic susceptibility to high myopia. EGR1 (显示 EGR1 ELISA试剂盒), JUN (显示 JUN ELISA试剂盒), FOS and VIP (显示 Vip ELISA试剂盒) are unlikely to be important in predisposing humans to high myopia.
Genetic testing for VIPR2-LCR-associated inversions should be performed on available cohorts of psychiatric patients to evaluate their potential pathogenic role
PACAP (显示 ADCYAP1 ELISA试剂盒)/PAC1 (显示 ADCYAP1R1 ELISA试剂盒) signaling is important for light regulated behavior, VIP (显示 Vip ELISA试剂盒)/VPAC2 signaling for stable clock function and both signaling pathways may play a role in shaping diurnality versus nocturnality.
Results demonstrate critical protective roles for PACAP (显示 ADCYAP1 ELISA试剂盒) and the VPAC2 receptor against autoimmunity, promoting the expansion and maintenance of the Treg pool.
The results suggest that caveolin-1 (显示 CAV1 ELISA试剂盒) plays an important role in VPAC2 receptor internalization and desensitization.
Cumulus cells express PACAP (显示 ADCYAP1 ELISA试剂盒) and its receptors PAC1-R and VPAC2-R.
VPAC2R mRNA expression showed a nonsignificant tendency to increase on day 7 after ischemia induced by bilateral common carotid artery occlusion.
The loss of adrenal clock gene rhythm in the VPAC2 receptor knockout mice after transfer into constant darkness was accompanied by disappearance of rhythmicity in Star mRNA expression and serum corticosterone concentration.
Cyclophosphamide-induced cystitis significantly decreased VPAC2 receptor expression in the urothelium & detrusor of both WT and NGF (显示 NGFB ELISA试剂盒)-OE mice
The circadian clock, not ambient light level, regulates Vipr2 protein localization, since VAPC2R plays a role in signaling at all times of day.
Data support the notion that both VPAC1 (显示 VIPR1 ELISA试剂盒) and VPAC2 receptors are dynamically regulated by Ikaros (显示 IKZF1 ELISA试剂盒), a master transcriptional regulator for thymocyte differentiation, during early thymic development.
results support that decline in VIP (显示 Vip ELISA试剂盒)/VPAC local levels may influence survival/apoptosis intracellular set point in NOD acinar cells and their clearance, contributing to gland homeostasis loss in a model of Sjogren's syndrome
This gene encodes a receptor for vasoactive intestinal peptide, a small neuropeptide. Vasoactive intestinal peptide is involved in smooth muscle relaxation, exocrine and endocrine secretion, and water and ion flux in lung and intestinal epithelia. Its actions are effected through integral membrane receptors associated with a guanine nucleotide binding protein which activates adenylate cyclase.
vasoactive intestinal peptide receptor 2
, vasoactive intestinal polypeptide receptor type 2
, histidine-isoleucine receptor
, pituitary adenylate cyclase-activating peptide
, vasoactive intestinal polypeptide receptor 2
, vasoactive intestingal polypeptide receptor type 2
, VPAC2 receptor
, VIP-specific receptor
, gastric VPAC2 receptor
, vasoactive intestinal polypeptide receptor 2-like
, vasoactive intestinal peptide/pituitary adenylate cyclase activating polypeptide receptor 2
, PACAP type III receptor
, VIP and PACAP receptor 2
, helodermin-preferring VIP receptor
, pituitary adenylate cyclase-activating polypeptide type III receptor
, VIP receptor subtype 2
, vasopressive intestinal peptide receptor 2