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Both FMRP deficiency in Fmr1(I304N) mice and Fmr1 knockdown impeded the axonal delivery of miR-181d, Map1b, and Calm1 and reduced the protein levels of MAP1B and calmodulin in axons.
The association of calcium-bound calmodulin (CaM) with DREAM is mediated by a short amphipathic amino acid sequence located between residues 29 and 44 on DREAM.
Calcium plays a role in regulating the expression and function of beta-adducin to sustain normal organization of the spectrin-based cytoskeleton and the differentiation properties in keratinocytes through the calmodulin/EGFR/cadherin signaling pathway.
Data suggest that Cys3602 in RyR2 (ryanodine receptor 2) plays important role in activation/termination of Ca2+ release, but it is not essential for calmodulin regulation of RyR2.
CaM plays an active role in shaping both the spatial and temporal aspects of calcineurin-mediated calcium signaling.
Calm1 signaling pathway is essential for the migration of mouse precerebellar neurons.
Ca(2+) binding to calmodulin induces major conformational changes in both IQ motifs and the post-IQ domain and increases flexibility of the myosin-1c tail.
Using mass spectrometry this study identified calmodulin as a calcium-dependent GluN2A (显示 GRIN2A 蛋白) binding partner.
new insights into the role of BTK (显示 BTK 蛋白), an important target for autoimmune diseases, in B cell activation (显示 BLNK 蛋白)
The relationships between the interaction of alphaCaMKII with CaM and the conformational change of alphaCaMKII, were investigated.
the conformational changes of calmodulin (显示 KRIT1 蛋白) upon Ca(2 (显示 CA2 蛋白)+) and mastoparan binding
MLCK and calmodulin (CaM) co-purify with unphosphorylated SMM from chicken gizzard, suggesting that they are tightly bound.
Our up-to-date review discusses CaM's role in PI3K signaling at the membrane in KRAS-driven cancers. This is significant since it may help development of K-Ras-specific pharmacology.
Calmodulin is up-regulated and can serve as the potential serum biomarker for predicting the recurrence of nasopharyngeal carcinoma.
cSH2 domain of p85alpha engages its two CaM-binding motifs in the interaction with the N- and C-lobes of CaM as well as the flexible central linker, and our nuclear magnetic resonance experiments provide structural details.
The dynamics of calmodulin interactions with neurogranin (显示 NRGN 蛋白) and Ca(2 (显示 CA2 蛋白)+) /CAMKII (显示 CAMK2G 蛋白) alpha proteins has been reported.
our work reveals a novel model by which CaM promotes cell migration through inhibiting the ubiquitination and degradation of TBC1D3 (显示 TBC1D3 蛋白).
Human arrhythmogenic calmodulin mutations impede the activation of SK2 (显示 KCNN2 蛋白) channels in human embryonic kidney 293 cells.
The results demonstrated CaM binding to DR5 (显示 TNFRSF10B 蛋白)-mediated DISC in a calcium dependent manner and may identify CaM as a key regulator of DR5 (显示 TNFRSF10B 蛋白)-mediated DISC formation for apoptosis in breast cancer.
Insights from structural proteomics can be used to generate CaM-insensitive mutants of CaM targets for functional studies in vitro or ideally in vivo.
The unique C terminus of the calcineurin isoform CNAbeta1 confers non-canonical regulation of enzyme activity by Ca(2+) and calmodulin
The main functional derangement in CALM1-F142L was prolonged repolarization with altered rate-dependency and sensitivity to beta-adrenergic stimulation.
analysis of CaM docked to a functioning KCNQ K(+) channel (KCNQ2 and KCNQ3) [KCNQ2, KCNQ3]
Asp-CaM complex has a critical role in centrosome-pole cohesion and centrosome inheritance in neural stem cells
Basal body formation in the male testes and the production of functional sperm does not rely on the PLP-CaM interaction, whereas production of functional mechanosensory neurons does.
characterized the interdomain motions in the calcium-bound state of calmodulin (Ca(2+)-CaM) using NMR chemical shifts as replica-averaged structural restraints in molecular dynamics simulations
Regulatory implications of a novel mode of interaction of calmodulin with a double IQ-motif target sequence from murine dilute myosin V (显示 MYO5A 蛋白).
null behavioral phenotype originates in the nervous system and involves a calmodulin function that requires calcium binding to all four sites of the protein
the direct interaction of melatonin with intact calcium-saturated CaM is calcium-dependent; Molecular dynamics simulations follow the dynamics of melatonin in the binding pocket of CaM
potential functional role for calmodulin in regulation of the glycolytic pathway
A mutation to the gene encoding calmodulin deregulates muscle contraction.
Drosophila CaM is able to fully activate inducible nitric oxide synthase (iNOS (显示 NOS2 蛋白)); moreover, iNOS (显示 NOS2 蛋白) activation by CaM, like neuronal NOS (显示 NOS1 蛋白), is not dependent on Ca2 (显示 CA2 蛋白)+ being bound to all four Ca2 (显示 CA2 蛋白)+-binding sites, but has specific and distinct requirements.
Calmodulin/CAMTA/Fbxl4 may mediate a long-term feedback regulation of the activity of Ca(2 (显示 CA2 蛋白)+)-stimulating G protein-coupled receptor (显示 GPBAR1 蛋白), which could prevent cell damage due to extra Ca(2 (显示 CA2 蛋白)+) influx.
This gene encodes a member of the EF-hand calcium-binding protein family. It is one of three genes which encode an identical calcium binding protein which is one of the four subunits of phosphorylase kinase. Two pseudogenes have been identified on chromosome 7 and X. Multiple transcript variants encoding different isoforms have been found for this gene.
, Calmodulin 1 (phosphorylase kinase, delta)
, calmodulin 2
, calmodulin 3
, calmodulin 1 (phosphorylase kinase, delta)
, phosphorylase kinase subunit delta
, phosphorylase kinase, delta subunit
, prepro-calmodulin 1
, Calmodulin-2 A
, Calmodulin-2 B
, CG8472 gene product from transcript CG8472-RC
, CaM Gamma 2