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Human Monoclonal PTGS2 Primary Antibody for IHC (p) - ABIN1687606
Yang, Hsu, Meng, Su: Supplement of 5-hydroxytryptophan before induction suppresses inflammation and collagen-induced arthritis. in Arthritis research & therapy 2015
Show all 29 Pubmed References
Human Monoclonal PTGS2 Primary Antibody for IHC (p) - ABIN1687611
Carvalho, Pires, Prada, Ferreira, Queiroga: Positive Interplay Between CD3+ T-lymphocytes and Concurrent COX-2/EGFR Expression in Canine Malignant Mammary Tumors. in Anticancer research 2015
Show all 24 Pubmed References
Human Polyclonal PTGS2 Primary Antibody for IHC (fro), IHC (p) - ABIN3044296
Guo, Li, Wu, Gong, Lu, Shi: Protective effects of icariin on brain dysfunction induced by lipopolysaccharide in rats. in Phytomedicine : international journal of phytotherapy and phytopharmacology 2010
Show all 15 Pubmed References
Human Polyclonal PTGS2 Primary Antibody for IHC, IHC (p) - ABIN152112
Chu, Yeh, Lin, Jung, Ma, Wang, Wu, Shiu, Chen: Deletion of the FHL2 gene attenuating neovascularization after corneal injury. in Investigative ophthalmology & visual science 2008
Show all 14 Pubmed References
Human Polyclonal PTGS2 Primary Antibody for IHC (p), WB - ABIN3044295
Liu, Yan, Li, Yin, Sun, Kou, Ye, Ferns, Liu, Liu: Reduced expression of SOX7 in ovarian cancer: a novel tumor suppressor through the Wnt/?-catenin signaling pathway. in Journal of ovarian research 2014
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Human Polyclonal PTGS2 Primary Antibody for IF (p), IHC (p) - ABIN672471
Gao, Wen, Yang, Lu, Tong, Huang, Liu, Tang: Celecoxib ameliorates portal hypertension of the cirrhotic rats through the dual inhibitory effects on the intrahepatic fibrosis and angiogenesis. in PLoS ONE 2013
Show all 9 Pubmed References
Chicken Monoclonal PTGS2 Primary Antibody for IF, IP - ABIN967823
Giroux, Descoteaux: Cyclooxygenase-2 expression in macrophages: modulation by protein kinase C-alpha. in Journal of immunology (Baltimore, Md. : 1950) 2000
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Chicken Monoclonal PTGS2 Primary Antibody for WB - ABIN967824
Hla, Neilson: Human cyclooxygenase-2 cDNA. in Proceedings of the National Academy of Sciences of the United States of America 1992
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Chicken Monoclonal PTGS2 Primary Antibody for IF, IP - ABIN967822
Marrogi, Pass, Khan, Metheny-Barlow, Harris, Gerwin: Human mesothelioma samples overexpress both cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (NOS2): in vitro antiproliferative effects of a COX-2 inhibitor. in Cancer research 2000
Show all 5 Pubmed References
Human Polyclonal PTGS2 Primary Antibody for ELISA, WB - ABIN257712
George, Morrow, Xu, Yi, Holmes, Wu, Li, Protter, Oz, Wang: Prolonged effects of B-type natriuretic peptide infusion on cardiac remodeling after sustained myocardial injury. in American journal of physiology. Heart and circulatory physiology 2009
Show all 4 Pubmed References
reviews the cardiovascular effects of COX-2 (显示 COX2 抗体) inhibitors with a focus on the mechanisms contributing to the clinical readouts of COX-2 (显示 COX2 抗体) inhibition.
Colorectal carcinoma harboring ALK (显示 ALK 抗体) fusions represent a rare aggressive subtype of colorectal carcinoma with distinct clinicopathologic features. This report provides the first clinical evidence that such patients may benefit from targeted monotherapy with ALK (显示 ALK 抗体) inhibitors.
This finding may provide a new option besides COX (显示 COX8A 抗体) inhibition to optimize cancer therapy. The outcome of this translational research will guide us to develop a novel omega-6-based diet-care strategy in combination with current chemotherapy for colon cancer prevention and treatment.
sUV activated the transcription factors nuclear factor-kappaB and activator protein-1 (显示 FOSB 抗体) which, in turn, induces COX-2 (显示 COX2 抗体) expression.
A single SNP (rs689466) localized at 5' -1192 of the PTGS2 gene exhibited significant association with febrile seizure (FS) based on case-control allelic association analyses. A significant decrease in the frequency of the G allele in FS was observed compared to that in controls. Using case-control genotypic association analysis, the -1192A allele is most likely to confer susceptibility to FS by a recessive action model.
The anticancer effects by 13'-COOHs appeared to be partially independent of inhibition of COX-2/5-LOX. Using liquid chromatography tandem mass spectrometry, we found that 13'-COOHs increased intracellular dihydrosphingosine and dihydroceramides after short-time incubation in HCT-116 cells, and enhanced ceramides while decreased sphingomyelins during prolonged treatment
Effects of pro-inflammatory cytokines, lipopolysaccharide and COX-2 (显示 COX2 抗体) mediators on human colonic neuromuscular function and epithelial permeability
High PTGS2 expression is associated with metastasis of esophageal squamous cell cancer.
Experimental results indicate that methylmercury inhibits the activity of protein tyrosine phosphatase 1B (显示 PTPN1 抗体), which in turn activates the epidermal growth factor receptor (显示 EGFR 抗体)-p38 mitogen-activated protein kinase (显示 MAPK14 抗体) pathway that induces cyclooxygenase-2 expression.
Our data suggest that the molecular network including TSP-1 (显示 THBS1 抗体), TGF-beta1 (显示 TGFB1 抗体), and PGE2 might be involved in the pathogenesis of acute angle closure glaucoma.
results revealed that a transient episode of raised-intensity phonation causes a significant increase in vocal fold inflammatory mRNA expression - IL-1beta (显示 IL1B 抗体),COX-2 (显示 COX2 抗体), and TGFbeta1 (显示 TGFB1 抗体)
The result demonstrate that mechanical stress on synovial cells induces gene expressions of COX-2 (显示 COX2 抗体).
Diabetes enhances the vasodilator response of the rabbit carotid artery to testosterone by a mechanism that includes an increased modulatory activity of the endothelial nitric oxide and an augmented release of COX-2 (显示 COX2 抗体) vasodilator, prostacyclin.
Local induction of COX-2 (显示 COX2 抗体) during atherosclerosis decreased the sensitivity to norepinephrine and that COX-2 (显示 COX2 抗体) inhibitors may increase vascular reactivity at sites of atherosclerotic lesions.
These findings suggest that nuclear factor kappa B(NF-kappaB (显示 NFKB1 抗体)) and cyclooxygenase-2 play roles in epidermal cell regeneration following beta-irradiation of mini-pig skin.
COX2 expression is upregulated in CAVD, and its activity contributes to osteogenic gene induction and valve calcification in vitro and in vivo.
These results suggest that COX-2 plays a role in the pathogenesis of Mycoplasma hyopneumoniae -infection.
Brain death increases the expression of COX-1 (显示 COX1 抗体) and COX-2 mRNA in the renal medulla
COX-2 is differentially expressed in normal versus lungworm-infected lungs of pigs and is likely to be involved in the pathogenesis of porcine parasitic bronchopneumonia.
In porcine vas (显示 AVP 抗体) deferens epithelial cell monolayers, increases in anion secretion were associated with preferential upregulation of PTGS2 at the mRNA and protein levels.
expression appears to be positively and negatively regulated by p38 MAPK (显示 MAPK14 抗体) and JNK (显示 MAPK8 抗体) pathways; alternatively, ERK1/2 (显示 MAPK1/3 抗体) appear to be involved in COX-2-independent reparative events that remain to be defined
Neutrophils augment recovery of transepithelial electrical resistance in ischemia-injured ileal mucosa via IL-1beta (显示 IL1B 抗体)-dependent upregulation of COX-2. (Cyclooxygenase 2)
Administration of estrogen early in pregnancy alters endometrial prostaglandin-endoperoxide synthase 2 (PTGS2) mRNA and protein expression, which may disrupt pregnancy causing total embryonic loss during implantation in the pig.
The effect of EGF (显示 EGF 抗体) on pro-inflammatory cytokines, tumor necrosis factor-alpha (TNF-alpha (显示 TNF 抗体)) and cyclooxygenase-2 (COX-2), levels during wound healing in swine is reported.
Cobalt protoporphyrin induces COX-2 (显示 COX2 抗体) expression through activating P2X7 (显示 P2RX7 抗体) receptors and ASK1 (显示 MAP3K5 抗体)/MAP kinases as well as PIAS1 (显示 PIAS1 抗体) degradation signaling pathways.
sUV activated the transcription factors nuclear factor-kappaB and activator protein-1 (显示 JUN 抗体) which, in turn, induces COX-2 (显示 COX2 抗体) expression.
Results indicate that Cox-2 (显示 COX2 抗体) promotes Col10a1 (显示 COL10A1 抗体) expression and chondrocyte hypertrophy in vitro.
These data reveal important structure-function and signaling differences between the two FFA4 isoforms, and for the first time link FFA4 to modulation of ROS (显示 ROS1 抗体) in macrophages.
Our data suggest that there are physiologically important gender differences in hypoxic acclimatization in COX-2 (显示 COX2 抗体)-deficient mice. The COX-2 (显示 COX2 抗体) signaling pathway appears to be required for acclimatization in oxygen-limiting environments only in males, whereas female COX-2 (显示 COX2 抗体)-deficient mice may be able to access COX-2 (显示 COX2 抗体)-independent mechanisms to achieve hypoxic acclimatization.
increased COX2 (显示 COX2 抗体) expression has an impact on the aging process
These results establish a novel signaling process whereby PAK1 (显示 PAK1 抗体) upregulates COX-2 (显示 COX2 抗体), reduces anandamide levels and restricts tonic endocannabinoids-mediated processes.
Angiotensin II-AT1-receptor (显示 AGTRAP 抗体) signaling is necessary for COX-2 (显示 COX2 抗体)-dependent normal postnatal nephrogenesis and maturation.
AhR (显示 AHR 抗体) controls COX-2 (显示 COX2 抗体) protein via mRNA stability.
Podocyte-specific knockout of COX2 (显示 COX2 抗体) enhanced albuminuria and did not attenuate the histologic features of diabetic kidney disease.
The objective of this study was to evaluate the mRNA expression of prostaglandin-endoperoxide synthase 2 (PTGS 2), prostaglandin F2alpha synthase (PTGFS) and prostaglandin E2 microsomal synthase 1 (mPTGES 1) in the endometrium of repeat-breeding cows with and without subclinical endometritis.
results indicate that nuclear receptor subfamily 1 group D member 1(REV-ERBalpha (显示 NR1D1 抗体)) plays an inhibitory role in the expression of prostaglandin-endoperoxide synthase 2(PTGS2) in both bovine USCs and UECs treated with ovarian steroids
This study showed that neutrophils from periparturient heifers show impairment of COX-2 mRNA expression and lactoferrin (显示 LTF 抗体), suggesting that these mechanisms may contribute to immunosuppression in cows around calving.
Exposure to follicular fluid transiently increased the transcript levels of IL8 (显示 IL8 抗体) and PTGS2, and decreased the expression of SOD2 (显示 SOD2 抗体), GPX3 (显示 GPX3 抗体), DAB2 (显示 DAB2 抗体), and NR3C1 (显示 NR3C1 抗体). TNF (显示 TNF 抗体) and IL6 (显示 IL6 抗体) levels were also decreased while those of NAMPT (显示 NAMPT 抗体) were unaffected.
Purinergic P2Y1 receptor (显示 P2RY1 抗体) signaling mediates wound stimuli-induced cyclooxygenase-2 expression in intestinal subepithelial myofibroblasts
Data suggest that Escherichia coli infections (here, administration of LPS (显示 IRF6 抗体)) provokes luteolysis in diestrus, non-lactating cows but no change in expression of PTGS2 in corpus luteum and has no effect on luteinization in the following cycle.
This study is the first to report the involvement of PGE2 in oocyte MAPK (显示 MAPK1 抗体) activation during the maturation process.
Inhibitors of c-Src (显示 SRC 抗体) (PP2, 10 microm) and PI3K (LY294002, 25 microm) produced a significant decrease in oxytocin-induced PGF (显示 PGF 抗体)(2 alpha) production and reduced COX2 expression by endometrial epithelial cells.
COX-2 pathway is responsible for the endometrial production of PGE (显示 LIPF 抗体)(2) in the bovine endometrium during the estrous cycle
the conceptus, through its secretion of IFN-tau, stimulates maternal epithelial expression of COX-2 and GM-CSF (显示 CSF2 抗体) during the peri (显示 PLIN1 抗体)-attachment period in the cow.
This study showed that COX-1 (显示 PTGS1 抗体) and COX-2 in genital carcinomas in the horse is poor; microsomal PGES (显示 PTGES 抗体)-1 is more prominently expressed.
Progestin treatment does not affect expression of cytokines, steroid receptors, oxytocin receptor (显示 OXTR 抗体), and cyclooxygenase 2 in fetal membranes and endometrium.
COX-1 (显示 PTGS1 抗体) and COX-2 genes were constitutively expressed in baseline samples. Low-flow ischemia resulted in significant upregulation of COX-2 gene expression at each subsequent time point, compared with baseline values.
The role for p38 (显示 MAPK14 抗体) mitogen-activated kinase (MAPK (显示 MAPK1 抗体)) in the signaling mechanism regulating pro-inflammatory cyclooxygenase (COX (显示 CPOX 抗体)) gene expression in lipopolysaccharide (LPS (显示 IRF6 抗体))-activated equine leukocytes in horses is reported.
In this study, both COX-1 (显示 PTGS1 抗体) and COX-2 were expressed in the colon before induced ischemia; ischemic injury increased expression of COX-2.
Immunoreactivity for COX-1 (显示 PTGS1 抗体) and COX-2 is high in equine corneal SCC (显示 CYP11A1 抗体), possibly indicating that COX (显示 CPOX 抗体) plays a role in oncogenesis or progression of this tumor type at this site.
It was found that most equine squamous-cell carcinomas and many melanomas appear to express COX-2 and thus could respond to COX-2 inhibitor therapy.
data support the hypothesis that prostaglandin G/H synthase 2(PGHS2)is a target for the antiluteolytic signal produced by equine conceptuses during early pregnancy
The vesicular gland of castrated goats showed significantly lower AR and COX-2 (显示 COX2 抗体) immuno-expression than intact goats indicating that both AR and COX-2 (显示 COX2 抗体) are androgen dependent.
Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes the inducible isozyme. It is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis.
PGH synthase 2
, PHS II
, cyclooxygenase 2b
, prostaglandin G/H synthase 2
, prostaglandin H2 synthase 2
, cyclooxygenase 2
, glucocorticoid-regulated inflammatory cyclooxygenase
, macrophage activation-associated marker protein P71/73
, prostaglandin G/H synthase and cyclooxygenase
, mitogen-inducible PGHS
, cyclooxygenase type 2
, prostaglandin G/H synthase-2
, cyclooxygenase, prostaglandin endoperoxide H synthase-2
, prostaglandin H synthase-2
, prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
, prostaglandin G/H synthase 2-like