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Human Polyclonal PTGS2 Primary Antibody for IHC (fro), IHC (p) - ABIN3044296
Guo, Li, Wu, Gong, Lu, Shi: Protective effects of icariin on brain dysfunction induced by lipopolysaccharide in rats. in Phytomedicine : international journal of phytotherapy and phytopharmacology 2010
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Human Polyclonal PTGS2 Primary Antibody for IHC, IHC (p) - ABIN152112
Chu, Yeh, Lin, Jung, Ma, Wang, Wu, Shiu, Chen: Deletion of the FHL2 gene attenuating neovascularization after corneal injury. in Investigative ophthalmology & visual science 2008
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Human Polyclonal PTGS2 Primary Antibody for IHC (p), WB - ABIN3044295
Liu, Yan, Li, Yin, Sun, Kou, Ye, Ferns, Liu, Liu: Reduced expression of SOX7 in ovarian cancer: a novel tumor suppressor through the Wnt/?-catenin signaling pathway. in Journal of ovarian research 2014
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Human Polyclonal PTGS2 Primary Antibody for IF (p), IHC (p) - ABIN672471
Gao, Wen, Yang, Lu, Tong, Huang, Liu, Tang: Celecoxib ameliorates portal hypertension of the cirrhotic rats through the dual inhibitory effects on the intrahepatic fibrosis and angiogenesis. in PLoS ONE 2013
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Human Polyclonal PTGS2 Primary Antibody for ELISA, WB - ABIN257712
George, Morrow, Xu, Yi, Holmes, Wu, Li, Protter, Oz, Wang: Prolonged effects of B-type natriuretic peptide infusion on cardiac remodeling after sustained myocardial injury. in American journal of physiology. Heart and circulatory physiology 2009
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Human Polyclonal PTGS2 Primary Antibody for IHC (p), WB - ABIN965923
Salmenkivi, Haglund, Ristimäki, Arola, Heikkilä: Increased expression of cyclooxygenase-2 in malignant pheochromocytomas. in The Journal of clinical endocrinology and metabolism 2001
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Human Polyclonal PTGS2 Primary Antibody for IHC (p), IHC - ABIN257983
Tong, Tai: Induction of NAD(+)-linked 15-hydroxyprostaglandin dehydrogenase expression by androgens in human prostate cancer cells. in Biochemical and biophysical research communications 2000
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Human Polyclonal PTGS2 Primary Antibody for IF (p), IHC (p) - ABIN2173482
Niu, Wang, Li, Mu, Li, Yao, Zhang: Protective effects of Isofraxidin against lipopolysaccharide-induced acute lung injury in mice. in International immunopharmacology 2015
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Human Polyclonal PTGS2 Primary Antibody for IHC, IHC (p) - ABIN4300170
Nuñez, Bravo, Cruzat, Montecino, De Ferrari: Wnt/β-catenin signaling enhances cyclooxygenase-2 (COX2) transcriptional activity in gastric cancer cells. in PLoS ONE 2011
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Chicken Polyclonal PTGS2 Primary Antibody for IHC, ELISA - ABIN1582099
Hsieh, Yang, Yang, Chou: Dry needling at myofascial trigger spots of rabbit skeletal muscles modulates the biochemicals associated with pain, inflammation, and hypoxia. in Evidence-based complementary and alternative medicine : eCAM 2013
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Results suggest that a significant correlation exists in Japan between the COX-2 (显示 COX2 抗体) 1195 G-carrier genotype and intestinal metaplasia in histological and endoscopic findings based on Kyoto classification in H. pylori-infected gastric mucosa.
activated Ras, protumorigenic COX-2 (显示 COX2 抗体) and Notch1 (显示 NOTCH1 抗体) have roles in in papillary mucinous neoplasm onset
TGF-beta1 (显示 TGFB1 抗体) increased the COX-2 (显示 COX2 抗体) and PGE2 level of cultured pulp cells. The effect of TGF-beta1 (显示 TGFB1 抗体) on COX-2 (显示 COX2 抗体) protein expression was associated with ALK5 (显示 TGFBR1 抗体)/Smad2 (显示 SMAD2 抗体)/3 and MEK (显示 MAP2K1 抗体)/ERK (显示 EPHB2 抗体) pathways.
Culinary herbs and spices prevent the growth of HCA-7 colorectal adenocarcinoma cancer cells and inhibit their COX-2 (显示 COX2 抗体) expression.
medical use of COX (显示 COX8A 抗体) inhibitors in glioblastoma treatment has been limited due to their well-documented vascular toxicity and inconsistent outcomes from recent human studies. Prostaglandin E2 (PGE2) has emerged as a principal mediator for COX-2 (显示 COX2 抗体) cascade-driven gliomagenesis
COX2 (显示 COX2 抗体) inversely regulated Notch1 (显示 NOTCH1 抗体) in gastric cancer and partially depended on the Notch1 (显示 NOTCH1 抗体) signalling pathway in altering the expression of Snail (显示 SNAI1 抗体).
Based on the contribution maps from the three techniques, it can be concluded that both the benzenesulfonyl group and the central five-membered ring - having a high-electronegativity functional group or atom or having a substituent hydrogen bonding acceptor - contribute positively to the selective inhibition of COX-2 (显示 COX2 抗体)
Findings demonstrate that COX-2 (显示 COX2 抗体) and p-Akt1 (显示 AKT1 抗体) play an important combined role during melanoma progression and are associated with highly metastatic tumors and survival rates in patients with MM.
Results suggest that higher COX-2 (显示 COX2 抗体) expression may be a negative prognostic factor in conjunctival melanoma. Further studies can address the potential use of anti-COX-2 (显示 COX2 抗体) drugs as adjuvant therapy of this disease.
activation of ERK1/2 signaling was required for hCG-induced up-regulation of SPRY2 expression. Further, SPRY2 knockdown attenuated the AREG-induced COX-2 expression and PGE2 production by inhibiting AREG-activated ERK1/2 signaling.
results revealed that a transient episode of raised-intensity phonation causes a significant increase in vocal fold inflammatory mRNA expression - IL-1beta (显示 IL1B 抗体),COX-2 (显示 COX2 抗体), and TGFbeta1 (显示 TGFB1 抗体)
The result demonstrate that mechanical stress on synovial cells induces gene expressions of COX-2 (显示 COX2 抗体).
Diabetes enhances the vasodilator response of the rabbit carotid artery to testosterone by a mechanism that includes an increased modulatory activity of the endothelial nitric oxide and an augmented release of COX-2 (显示 COX2 抗体) vasodilator, prostacyclin.
Local induction of COX-2 (显示 COX2 抗体) during atherosclerosis decreased the sensitivity to norepinephrine and that COX-2 (显示 COX2 抗体) inhibitors may increase vascular reactivity at sites of atherosclerotic lesions.
These findings suggest that nuclear factor kappa B(NF-kappaB (显示 NFKB1 抗体)) and cyclooxygenase-2 play roles in epidermal cell regeneration following beta-irradiation of mini-pig skin.
COX2 expression is upregulated in CAVD, and its activity contributes to osteogenic gene induction and valve calcification in vitro and in vivo.
These results suggest that COX-2 plays a role in the pathogenesis of Mycoplasma hyopneumoniae -infection.
Brain death increases the expression of COX-1 (显示 COX1 抗体) and COX-2 mRNA in the renal medulla
COX-2 is differentially expressed in normal versus lungworm-infected lungs of pigs and is likely to be involved in the pathogenesis of porcine parasitic bronchopneumonia.
In porcine vas (显示 AVP 抗体) deferens epithelial cell monolayers, increases in anion secretion were associated with preferential upregulation of PTGS2 at the mRNA and protein levels.
expression appears to be positively and negatively regulated by p38 MAPK (显示 MAPK14 抗体) and JNK (显示 MAPK8 抗体) pathways; alternatively, ERK1/2 appear to be involved in COX-2-independent reparative events that remain to be defined
Neutrophils augment recovery of transepithelial electrical resistance in ischemia-injured ileal mucosa via IL-1beta (显示 IL1B 抗体)-dependent upregulation of COX-2. (Cyclooxygenase 2)
Administration of estrogen early in pregnancy alters endometrial prostaglandin-endoperoxide synthase 2 (PTGS2) mRNA and protein expression, which may disrupt pregnancy causing total embryonic loss during implantation in the pig.
The effect of EGF (显示 EGF 抗体) on pro-inflammatory cytokines, tumor necrosis factor-alpha (TNF-alpha (显示 TNF 抗体)) and cyclooxygenase-2 (COX-2), levels during wound healing in swine is reported.
Mitochondrial catalase (显示 CAT 抗体) induces neoplastic cell transformation through nucleolin (显示 NCL 抗体)-dependent Cox-2 (显示 COX2 抗体) mRNA stabilization.
The COX2 (显示 COX2 抗体)-dependent lipid inflammatory pathway is responsible for lethality in F. novicida infection due to overproduction of proinflammatory effectors including prostaglandin E2.
These data indicate the functional role of the MIF (显示 MIF 抗体)-COX (显示 CPOX 抗体)-p53 (显示 TP53 抗体) axis in inflammation and cancer at the genomic and proteomic levels in COX-2 (显示 COX2 抗体)-ablated cells.
PTGS2 deletion changes the natural distribution of ANXA2 (显示 ANXA2 抗体) in monocytes/macrophages, increasing TF expression and activity predisposing to venous thrombosis.
Study suggest that amyloid beta-protein increase the expression of TRPC6 (显示 TRPC6 抗体) via NF-kappaB (显示 NFKB1 抗体) in BV-2 microglia and promotes the production of COX-2 (显示 COX2 抗体), which induces hippocampus neuron damage.
Data show that patients with high cyclooxygenase-2 (COX2) gene expression who received celecoxib had a significantly higherpathological complete response (pCR) rate compared with patients with low COX2 (显示 COX2 抗体) gene expression.
Topical application of glycolic acid suppresses the UVB induced IL-6 (显示 IL6 抗体), IL-8 (显示 IL8 抗体), MCP-1 (显示 CPT1B 抗体) and COX-2 (显示 COX2 抗体) inflammation by modulating NF-kappaB (显示 NFKB1 抗体) signaling pathway in mouse skin.
COX-2 (显示 COX2 抗体)/mPGES-1 (显示 PTGES 抗体)/PGE2 cascade activation mediates uric acid-induced glomerular mesangial cell proliferation.
Cobalt protoporphyrin induces COX-2 (显示 COX2 抗体) expression through activating P2X7 (显示 P2RX7 抗体) receptors and ASK1 (显示 MAP3K5 抗体)/MAP kinases as well as PIAS1 (显示 PIAS1 抗体) degradation signaling pathways.
sUV activated the transcription factors nuclear factor-kappaB and activator protein-1 (显示 JUN 抗体) which, in turn, induces COX-2 (显示 COX2 抗体) expression.
Data suggested that PTGS-2 gene expression was induced by PTGER2 (显示 PTGER2 抗体) activation through the PKA and ERK (显示 MAPK1 抗体) pathways.
The objective of this study was to evaluate the mRNA expression of prostaglandin-endoperoxide synthase 2 (PTGS 2), prostaglandin F2alpha synthase (PTGFS) and prostaglandin E2 microsomal synthase 1 (mPTGES 1) in the endometrium of repeat-breeding cows with and without subclinical endometritis.
results indicate that nuclear receptor subfamily 1 group D member 1(REV-ERBalpha (显示 NR1D1 抗体)) plays an inhibitory role in the expression of prostaglandin-endoperoxide synthase 2(PTGS2) in both bovine USCs and UECs treated with ovarian steroids
This study showed that neutrophils from periparturient heifers show impairment of COX-2 mRNA expression and lactoferrin (显示 LTF 抗体), suggesting that these mechanisms may contribute to immunosuppression in cows around calving.
Exposure to follicular fluid transiently increased the transcript levels of IL8 (显示 IL8 抗体) and PTGS2, and decreased the expression of SOD2 (显示 SOD2 抗体), GPX3 (显示 GPX3 抗体), DAB2 (显示 DAB2 抗体), and NR3C1 (显示 NR3C1 抗体). TNF (显示 TNF 抗体) and IL6 (显示 IL6 抗体) levels were also decreased while those of NAMPT (显示 NAMPT 抗体) were unaffected.
Purinergic P2Y1 receptor (显示 P2RY1 抗体) signaling mediates wound stimuli-induced cyclooxygenase-2 expression in intestinal subepithelial myofibroblasts
Data suggest that Escherichia coli infections (here, administration of LPS (显示 IRF6 抗体)) provokes luteolysis in diestrus, non-lactating cows but no change in expression of PTGS2 in corpus luteum and has no effect on luteinization in the following cycle.
This study is the first to report the involvement of PGE2 in oocyte MAPK (显示 MAPK1 抗体) activation during the maturation process.
Inhibitors of c-Src (显示 SRC 抗体) (PP2, 10 microm) and PI3K (LY294002, 25 microm) produced a significant decrease in oxytocin-induced PGF (显示 PGF 抗体)(2 alpha) production and reduced COX2 expression by endometrial epithelial cells.
COX-2 pathway is responsible for the endometrial production of PGE (显示 LIPF 抗体)(2) in the bovine endometrium during the estrous cycle
This study showed that COX-1 (显示 PTGS1 抗体) and COX-2 in genital carcinomas in the horse is poor; microsomal PGES (显示 PTGES 抗体)-1 is more prominently expressed.
Progestin treatment does not affect expression of cytokines, steroid receptors, oxytocin receptor (显示 OXTR 抗体), and cyclooxygenase 2 in fetal membranes and endometrium.
COX-1 (显示 PTGS1 抗体) and COX-2 genes were constitutively expressed in baseline samples. Low-flow ischemia resulted in significant upregulation of COX-2 gene expression at each subsequent time point, compared with baseline values.
The role for p38 (显示 MAPK14 抗体) mitogen-activated kinase (MAPK (显示 MAPK1 抗体)) in the signaling mechanism regulating pro-inflammatory cyclooxygenase (COX (显示 CPOX 抗体)) gene expression in lipopolysaccharide (LPS (显示 IRF6 抗体))-activated equine leukocytes in horses is reported.
In this study, both COX-1 (显示 PTGS1 抗体) and COX-2 were expressed in the colon before induced ischemia; ischemic injury increased expression of COX-2.
Immunoreactivity for COX-1 (显示 PTGS1 抗体) and COX-2 is high in equine corneal SCC (显示 CYP11A1 抗体), possibly indicating that COX (显示 CPOX 抗体) plays a role in oncogenesis or progression of this tumor type at this site.
It was found that most equine squamous-cell carcinomas and many melanomas appear to express COX-2 and thus could respond to COX-2 inhibitor therapy.
data support the hypothesis that prostaglandin G/H synthase 2(PGHS2)is a target for the antiluteolytic signal produced by equine conceptuses during early pregnancy
The vesicular gland of castrated goats showed significantly lower AR and COX-2 (显示 COX2 抗体) immuno-expression than intact goats indicating that both AR and COX-2 (显示 COX2 抗体) are androgen dependent.
Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes the inducible isozyme. It is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis.
PGH synthase 2
, PHS II
, cyclooxygenase 2b
, prostaglandin G/H synthase 2
, prostaglandin H2 synthase 2
, cyclooxygenase 2
, glucocorticoid-regulated inflammatory cyclooxygenase
, macrophage activation-associated marker protein P71/73
, prostaglandin G/H synthase and cyclooxygenase
, mitogen-inducible PGHS
, cyclooxygenase type 2
, prostaglandin G/H synthase-2
, cyclooxygenase, prostaglandin endoperoxide H synthase-2
, prostaglandin H synthase-2
, prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
, prostaglandin G/H synthase 2-like