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Human Polyclonal PTGS2 Primary Antibody for IHC (p), WB - ABIN3044295
Guo, Li, Wu, Gong, Lu, Shi: Protective effects of icariin on brain dysfunction induced by lipopolysaccharide in rats. in Phytomedicine : international journal of phytotherapy and phytopharmacology 2010
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Human Polyclonal PTGS2 Primary Antibody for IHC (fro), IHC (p) - ABIN3044296
Liu, Yan, Li, Yin, Sun, Kou, Ye, Ferns, Liu, Liu: Reduced expression of SOX7 in ovarian cancer: a novel tumor suppressor through the Wnt/?-catenin signaling pathway. in Journal of ovarian research 2014
Show all 31 Pubmed References
Human Polyclonal PTGS2 Primary Antibody for WB - ABIN5518867
Wang, Du, Wang, Kuang, Wang: Z-ligustilide attenuates lipopolysaccharide-induced proinflammatory response via inhibiting NF-kappaB pathway in primary rat microglia. in Acta pharmacologica Sinica 2010
Show all 19 Pubmed References
Human Polyclonal PTGS2 Primary Antibody for IHC, IHC (p) - ABIN152112
Chu, Yeh, Lin, Jung, Ma, Wang, Wu, Shiu, Chen: Deletion of the FHL2 gene attenuating neovascularization after corneal injury. in Investigative ophthalmology & visual science 2008
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Human Polyclonal PTGS2 Primary Antibody for IF (p), IHC (p) - ABIN672471
Gao, Wen, Yang, Lu, Tong, Huang, Liu, Tang: Celecoxib ameliorates portal hypertension of the cirrhotic rats through the dual inhibitory effects on the intrahepatic fibrosis and angiogenesis. in PLoS ONE 2013
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Human Polyclonal PTGS2 Primary Antibody for ELISA, WB - ABIN257712
George, Morrow, Xu, Yi, Holmes, Wu, Li, Protter, Oz, Wang: Prolonged effects of B-type natriuretic peptide infusion on cardiac remodeling after sustained myocardial injury. in American journal of physiology. Heart and circulatory physiology 2009
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Polyclonal PTGS2 Primary Antibody for IHC (p), WB - ABIN540585
Liu, Chang, Narko, Trifan, Wu, Smith, Haudenschild, Lane, Hla: Overexpression of cyclooxygenase-2 is sufficient to induce tumorigenesis in transgenic mice. in The Journal of biological chemistry 2001
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Human Polyclonal PTGS2 Primary Antibody for IHC (p), WB - ABIN965923
Salmenkivi, Haglund, Ristimäki, Arola, Heikkilä: Increased expression of cyclooxygenase-2 in malignant pheochromocytomas. in The Journal of clinical endocrinology and metabolism 2001
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Human Polyclonal PTGS2 Primary Antibody for IF (p), IHC (p) - ABIN2173482
Niu, Wang, Li, Mu, Li, Yao, Zhang: Protective effects of Isofraxidin against lipopolysaccharide-induced acute lung injury in mice. in International immunopharmacology 2015
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Human Polyclonal PTGS2 Primary Antibody for IHC (p), IHC - ABIN257983
Tong, Tai: Induction of NAD(+)-linked 15-hydroxyprostaglandin dehydrogenase expression by androgens in human prostate cancer cells. in Biochemical and biophysical research communications 2000
Show all 2 Pubmed References
COX-2 (显示 COX2 抗体) is an important factor for Dengue virus replication.
Lysophosphatidylcholine induces COX-2 (显示 COX2 抗体)-mediated IL-6 (显示 IL6 抗体) expression. NADPH oxidase (显示 NOX1 抗体)/Reactive Oxygen Species is involved in Lysophosphatidylcholine-induced COX-2 (显示 COX2 抗体) expression.
results support a critical role of ATF6alpha (显示 ATF6 抗体) in the establishment and maintenance of cellular senescence in normal human fibroblasts via the up-regulation of a COX2 (显示 COX2 抗体)/PGE2 intracrine pathway.
High PTGS2 expression is associated with Breast Carcinoma.
concluded that COX-2 (显示 COX2 抗体) gene rs5275 variant contributes to Nasopharyngeal carcinoma risk in a Chinese population
COX2 (显示 COX2 抗体) and YAP1 (显示 YAP1 抗体) signaling pathways are connected with each other to induce SOX2 (显示 SOX2 抗体) expression, cancer stem cell enrichment, and acquired resistance to chemotherapy in urothelial carcinoma of the bladder.
No significant association between COX-2 (显示 COX2 抗体) 8473 T > C polymorphism and cancer risk was detected.
The results revealed that TLR4 (显示 TLR4 抗体) and COX-2 (显示 COX2 抗体) were upregulated in PCa (显示 FLVCR1 抗体) tissues; silencing of TLR4 (显示 TLR4 抗体) or COX-2 (显示 COX2 抗体) inhibited PCa (显示 FLVCR1 抗体) cell proliferation, migration, and invasion.
Results describe a novel role for cyclooxygenase-2 (COX-2) in mediating the TGFbeta (显示 TGFB1 抗体) effects on breast cancer stem cells (BCSC) properties and imply that targeting the COX-2 (显示 COX2 抗体) pathway may prove useful for the treatment of triple-negative breast cancer by eliminating BCSCs.
the effects of miR (显示 MLXIP 抗体)-101 inhibition on tumor growth were suppressed by COX-2 (显示 COX2 抗体) inhibition.
results revealed that a transient episode of raised-intensity phonation causes a significant increase in vocal fold inflammatory mRNA expression - IL-1beta (显示 IL1B 抗体),COX-2 (显示 COX2 抗体), and TGFbeta1 (显示 TGFB1 抗体)
The result demonstrate that mechanical stress on synovial cells induces gene expressions of COX-2 (显示 COX2 抗体).
Diabetes enhances the vasodilator response of the rabbit carotid artery to testosterone by a mechanism that includes an increased modulatory activity of the endothelial nitric oxide and an augmented release of COX-2 (显示 COX2 抗体) vasodilator, prostacyclin.
Local induction of COX-2 (显示 COX2 抗体) during atherosclerosis decreased the sensitivity to norepinephrine and that COX-2 (显示 COX2 抗体) inhibitors may increase vascular reactivity at sites of atherosclerotic lesions.
These findings suggest that nuclear factor kappa B(NF-kappaB (显示 NFKB1 抗体)) and cyclooxygenase-2 play roles in epidermal cell regeneration following beta-irradiation of mini-pig skin.
COX2 expression is upregulated in CAVD, and its activity contributes to osteogenic gene induction and valve calcification in vitro and in vivo.
These results suggest that COX-2 plays a role in the pathogenesis of Mycoplasma hyopneumoniae -infection.
Brain death increases the expression of COX-1 (显示 COX1 抗体) and COX-2 mRNA in the renal medulla
COX-2 is differentially expressed in normal versus lungworm-infected lungs of pigs and is likely to be involved in the pathogenesis of porcine parasitic bronchopneumonia.
In porcine vas (显示 AVP 抗体) deferens epithelial cell monolayers, increases in anion secretion were associated with preferential upregulation of PTGS2 at the mRNA and protein levels.
expression appears to be positively and negatively regulated by p38 MAPK (显示 MAPK14 抗体) and JNK (显示 MAPK8 抗体) pathways; alternatively, ERK1/2 appear to be involved in COX-2-independent reparative events that remain to be defined
Neutrophils augment recovery of transepithelial electrical resistance in ischemia-injured ileal mucosa via IL-1beta (显示 IL1B 抗体)-dependent upregulation of COX-2. (Cyclooxygenase 2)
Administration of estrogen early in pregnancy alters endometrial prostaglandin-endoperoxide synthase 2 (PTGS2) mRNA and protein expression, which may disrupt pregnancy causing total embryonic loss during implantation in the pig.
The effect of EGF (显示 EGF 抗体) on pro-inflammatory cytokines, tumor necrosis factor-alpha (TNF-alpha (显示 TNF 抗体)) and cyclooxygenase-2 (COX-2), levels during wound healing in swine is reported.
The kidney is the principle site in the body where local COX-2 (显示 COX2 抗体) controls blood flow via PPARbeta (显示 PPARD 抗体)/delta-mediated renal vasodilator pathway.
Mitochondrial catalase (显示 CAT 抗体) induces neoplastic cell transformation through nucleolin (显示 NCL 抗体)-dependent Cox-2 (显示 COX2 抗体) mRNA stabilization.
The COX2 (显示 COX2 抗体)-dependent lipid inflammatory pathway is responsible for lethality in F. novicida infection due to overproduction of proinflammatory effectors including prostaglandin E2.
These data indicate the functional role of the MIF (显示 MIF 抗体)-COX (显示 CPOX 抗体)-p53 (显示 TP53 抗体) axis in inflammation and cancer at the genomic and proteomic levels in COX-2 (显示 COX2 抗体)-ablated cells.
PTGS2 deletion changes the natural distribution of ANXA2 (显示 ANXA2 抗体) in monocytes/macrophages, increasing TF expression and activity predisposing to venous thrombosis.
Study suggest that amyloid beta-protein increase the expression of TRPC6 (显示 TRPC6 抗体) via NF-kappaB (显示 NFKB1 抗体) in BV-2 microglia and promotes the production of COX-2 (显示 COX2 抗体), which induces hippocampus neuron damage.
Data show that patients with high cyclooxygenase-2 (COX2) gene expression who received celecoxib had a significantly higherpathological complete response (pCR) rate compared with patients with low COX2 (显示 COX2 抗体) gene expression.
Topical application of glycolic acid suppresses the UVB induced IL-6 (显示 IL6 抗体), IL-8 (显示 IL8 抗体), MCP-1 (显示 CPT1B 抗体) and COX-2 (显示 COX2 抗体) inflammation by modulating NF-kappaB (显示 NFKB1 抗体) signaling pathway in mouse skin.
COX-2 (显示 COX2 抗体)/mPGES-1 (显示 PTGES 抗体)/PGE2 cascade activation mediates uric acid-induced glomerular mesangial cell proliferation.
Data suggested that PTGS-2 gene expression was induced by PTGER2 (显示 PTGER2 抗体) activation through the PKA and ERK (显示 MAPK1 抗体) pathways.
The objective of this study was to evaluate the mRNA expression of prostaglandin-endoperoxide synthase 2 (PTGS 2), prostaglandin F2alpha synthase (PTGFS) and prostaglandin E2 microsomal synthase 1 (mPTGES 1) in the endometrium of repeat-breeding cows with and without subclinical endometritis.
results indicate that nuclear receptor subfamily 1 group D member 1(REV-ERBalpha (显示 NR1D1 抗体)) plays an inhibitory role in the expression of prostaglandin-endoperoxide synthase 2(PTGS2) in both bovine USCs and UECs treated with ovarian steroids
This study showed that neutrophils from periparturient heifers show impairment of COX-2 mRNA expression and lactoferrin (显示 LTF 抗体), suggesting that these mechanisms may contribute to immunosuppression in cows around calving.
Exposure to follicular fluid transiently increased the transcript levels of IL8 (显示 IL8 抗体) and PTGS2, and decreased the expression of SOD2 (显示 SOD2 抗体), GPX3 (显示 GPX3 抗体), DAB2 (显示 DAB2 抗体), and NR3C1 (显示 NR3C1 抗体). TNF (显示 TNF 抗体) and IL6 (显示 IL6 抗体) levels were also decreased while those of NAMPT (显示 NAMPT 抗体) were unaffected.
Purinergic P2Y1 receptor (显示 P2RY1 抗体) signaling mediates wound stimuli-induced cyclooxygenase-2 expression in intestinal subepithelial myofibroblasts
Data suggest that Escherichia coli infections (here, administration of LPS (显示 IRF6 抗体)) provokes luteolysis in diestrus, non-lactating cows but no change in expression of PTGS2 in corpus luteum and has no effect on luteinization in the following cycle.
This study is the first to report the involvement of PGE2 in oocyte MAPK (显示 MAPK1 抗体) activation during the maturation process.
Inhibitors of c-Src (显示 SRC 抗体) (PP2, 10 microm) and PI3K (LY294002, 25 microm) produced a significant decrease in oxytocin-induced PGF (显示 PGF 抗体)(2 alpha) production and reduced COX2 expression by endometrial epithelial cells.
COX-2 pathway is responsible for the endometrial production of PGE (显示 LIPF 抗体)(2) in the bovine endometrium during the estrous cycle
This study showed that COX-1 (显示 PTGS1 抗体) and COX-2 in genital carcinomas in the horse is poor; microsomal PGES (显示 PTGES 抗体)-1 is more prominently expressed.
Progestin treatment does not affect expression of cytokines, steroid receptors, oxytocin receptor (显示 OXTR 抗体), and cyclooxygenase 2 in fetal membranes and endometrium.
COX-1 (显示 PTGS1 抗体) and COX-2 genes were constitutively expressed in baseline samples. Low-flow ischemia resulted in significant upregulation of COX-2 gene expression at each subsequent time point, compared with baseline values.
The role for p38 (显示 MAPK14 抗体) mitogen-activated kinase (MAPK (显示 MAPK1 抗体)) in the signaling mechanism regulating pro-inflammatory cyclooxygenase (COX (显示 CPOX 抗体)) gene expression in lipopolysaccharide (LPS (显示 IRF6 抗体))-activated equine leukocytes in horses is reported.
In this study, both COX-1 (显示 PTGS1 抗体) and COX-2 were expressed in the colon before induced ischemia; ischemic injury increased expression of COX-2.
Immunoreactivity for COX-1 (显示 PTGS1 抗体) and COX-2 is high in equine corneal SCC (显示 CYP11A1 抗体), possibly indicating that COX (显示 CPOX 抗体) plays a role in oncogenesis or progression of this tumor type at this site.
It was found that most equine squamous-cell carcinomas and many melanomas appear to express COX-2 and thus could respond to COX-2 inhibitor therapy.
data support the hypothesis that prostaglandin G/H synthase 2(PGHS2)is a target for the antiluteolytic signal produced by equine conceptuses during early pregnancy
The vesicular gland of castrated goats showed significantly lower AR and COX-2 (显示 COX2 抗体) immuno-expression than intact goats indicating that both AR and COX-2 (显示 COX2 抗体) are androgen dependent.
Mutations in the APC gene resultt in impaired retinoic acid biosynthesis and upegulation of cox2 (显示 COX2 抗体).
Retinoic acid inhibits beta-catenin (显示 CTNNB1 抗体) through suppression of Cox-2
Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes the inducible isozyme. It is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis.
PGH synthase 2
, PHS II
, cyclooxygenase 2b
, prostaglandin G/H synthase 2
, prostaglandin H2 synthase 2
, cyclooxygenase 2
, glucocorticoid-regulated inflammatory cyclooxygenase
, macrophage activation-associated marker protein P71/73
, prostaglandin G/H synthase and cyclooxygenase
, mitogen-inducible PGHS
, cyclooxygenase type 2
, prostaglandin G/H synthase-2
, cyclooxygenase, prostaglandin endoperoxide H synthase-2
, prostaglandin H synthase-2
, prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
, prostaglandin G/H synthase 2-like
, prostaglandin-endoperoxide synthase 2