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Mouse (Murine) COX2 ELISA Kit for Sandwich ELISA - ABIN426443
Cherng, Tsai, Yu, Lin: Molecular mechanisms underlying chemopreventive activities of glycyrrhizic acid against UVB-radiation-induced carcinogenesis in SKH-1 hairless mouse epidermis. in Radiation research 2011
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Rat (Rattus) COX2 ELISA Kit for Competition ELISA - ABIN1052816
Sakthivel, Guruvayoorappan: Protective effect of Acacia ferruginea against ulcerative colitis via modulating inflammatory mediators, cytokine profile and NF-?B signal transduction pathways. in Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer 2014
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Mouse (Murine) COX2 ELISA Kit for Competition ELISA - ABIN1052813
V, C: Protective effect of marine mangrove Rhizophora apiculata on acetic acid induced experimental colitis by regulating anti-oxidant enzymes, inflammatory mediators and nuclear factor-kappa B subunits. in International immunopharmacology 2014
Studied role of HPV16 E6 and COX-2 in invasive ductal breast cancer using qPCR and IHC, and in vitro studies. Found HPV16 E6 promoted breast cancer proliferation; Cox-2 inhibition suppressed HPV16 E6 effects on proliferation thru NF-kappaB (显示 NFKB1 ELISA试剂盒) signaling pathway.
reviews the cardiovascular effects of COX-2 inhibitors with a focus on the mechanisms contributing to the clinical readouts of COX-2 inhibition.
Colorectal carcinoma harboring ALK (显示 ALK ELISA试剂盒) fusions represent a rare aggressive subtype of colorectal carcinoma with distinct clinicopathologic features. This report provides the first clinical evidence that such patients may benefit from targeted monotherapy with ALK (显示 ALK ELISA试剂盒) inhibitors.
This finding may provide a new option besides COX (显示 COX8A ELISA试剂盒) inhibition to optimize cancer therapy. The outcome of this translational research will guide us to develop a novel omega-6-based diet-care strategy in combination with current chemotherapy for colon cancer prevention and treatment.
sUV activated the transcription factors nuclear factor-kappaB and activator protein-1 (显示 FOSB ELISA试剂盒) which, in turn, induces COX-2 expression.
A single SNP (rs689466) localized at 5' -1192 of the PTGS2 (显示 PTGS2 ELISA试剂盒) gene exhibited significant association with febrile seizure (FS) based on case-control allelic association analyses. A significant decrease in the frequency of the G allele in FS was observed compared to that in controls. Using case-control genotypic association analysis, the -1192A allele is most likely to confer susceptibility to FS by a recessive action model.
The anticancer effects by 13'-COOHs appeared to be partially independent of inhibition of COX-2/5-LOX. Using liquid chromatography tandem mass spectrometry, we found that 13'-COOHs increased intracellular dihydrosphingosine and dihydroceramides after short-time incubation in HCT-116 cells, and enhanced ceramides while decreased sphingomyelins during prolonged treatment
Effects of pro-inflammatory cytokines, lipopolysaccharide and COX-2 mediators on human colonic neuromuscular function and epithelial permeability
High PTGS2 (显示 PTGS2 ELISA试剂盒) expression is associated with metastasis of esophageal squamous cell cancer.
Experimental results indicate that methylmercury inhibits the activity of protein tyrosine phosphatase 1B (显示 PTPN1 ELISA试剂盒), which in turn activates the epidermal growth factor receptor (显示 EGFR ELISA试剂盒)-p38 mitogen-activated protein kinase (显示 MAPK14 ELISA试剂盒) pathway that induces cyclooxygenase-2 (显示 PTGS2 ELISA试剂盒) expression.
These findings suggest that nuclear factor kappa B(NF-kappaB (显示 NFKB1 ELISA试剂盒)) and cyclooxygenase-2 (显示 PTGS2 ELISA试剂盒) play roles in epidermal cell regeneration following beta-irradiation of mini-pig skin.
B1 receptors are coupled to COX2 (显示 PTGS2 ELISA试剂盒) in causing endothelium-independent contractions in endotoxin-treated pig coronary arteries
COX2 (显示 PTGS2 ELISA试剂盒) expression is upregulated in CAVD, and its activity contributes to osteogenic gene induction and valve calcification in vitro and in vivo.
These results suggest that COX-2 (显示 PTGS2 ELISA试剂盒) plays a role in the pathogenesis of Mycoplasma hyopneumoniae -infection.
Brain death increases the expression of COX-1 (显示 COX1 ELISA试剂盒) and COX-2 (显示 PTGS2 ELISA试剂盒) mRNA in the renal medulla
Expression of COX-2 (显示 PTGS2 ELISA试剂盒) was strongest in gilts with acute endometritis, but did not differ between those with chronic endometritis and normal endometrium.
COX-2 (显示 PTGS2 ELISA试剂盒) is differentially expressed in normal versus lungworm-infected lungs of pigs and is likely to be involved in the pathogenesis of porcine parasitic bronchopneumonia.
In porcine vas (显示 AVP ELISA试剂盒) deferens epithelial cell monolayers, increases in anion secretion were associated with preferential upregulation of PTGS2 (显示 PTGS2 ELISA试剂盒) at the mRNA and protein levels.
expression appears to be positively and negatively regulated by p38 MAPK (显示 MAPK14 ELISA试剂盒) and JNK (显示 MAPK8 ELISA试剂盒) pathways; alternatively, ERK1/2 (显示 MAPK1/3 ELISA试剂盒) appear to be involved in COX-2 (显示 PTGS2 ELISA试剂盒)-independent reparative events that remain to be defined
Neutrophils augment recovery of transepithelial electrical resistance in ischemia-injured ileal mucosa via IL-1beta (显示 IL1B ELISA试剂盒)-dependent upregulation of COX-2 (显示 PTGS2 ELISA试剂盒). (Cyclooxygenase 2 (显示 PTGS2 ELISA试剂盒))
Cobalt protoporphyrin induces COX-2 expression through activating P2X7 (显示 P2RX7 ELISA试剂盒) receptors and ASK1 (显示 MAP3K5 ELISA试剂盒)/MAP kinases as well as PIAS1 (显示 PIAS1 ELISA试剂盒) degradation signaling pathways.
sUV activated the transcription factors nuclear factor-kappaB and activator protein-1 (显示 JUN ELISA试剂盒) which, in turn, induces COX-2 expression.
Results indicate that Cox-2 promotes Col10a1 (显示 COL10A1 ELISA试剂盒) expression and chondrocyte hypertrophy in vitro.
These data reveal important structure-function and signaling differences between the two FFA4 isoforms, and for the first time link FFA4 to modulation of ROS (显示 ROS1 ELISA试剂盒) in macrophages.
Our data suggest that there are physiologically important gender differences in hypoxic acclimatization in COX-2-deficient mice. The COX-2 signaling pathway appears to be required for acclimatization in oxygen-limiting environments only in males, whereas female COX-2-deficient mice may be able to access COX-2-independent mechanisms to achieve hypoxic acclimatization.
increased COX2 expression has an impact on the aging process
These results establish a novel signaling process whereby PAK1 (显示 PAK1 ELISA试剂盒) upregulates COX-2, reduces anandamide levels and restricts tonic endocannabinoids-mediated processes.
Angiotensin II-AT1-receptor (显示 AGTRAP ELISA试剂盒) signaling is necessary for COX-2-dependent normal postnatal nephrogenesis and maturation.
AhR (显示 AHR ELISA试剂盒) controls COX-2 protein via mRNA stability.
Podocyte-specific knockout of COX2 enhanced albuminuria and did not attenuate the histologic features of diabetic kidney disease.
The objective of this study was to evaluate the mRNA expression of prostaglandin-endoperoxide synthase 2 (PTGS 2 (显示 PTGS2 ELISA试剂盒)), prostaglandin F2alpha synthase (PTGFS) and prostaglandin E2 microsomal synthase 1 (mPTGES 1) in the endometrium of repeat-breeding cows with and without subclinical endometritis.
results indicate that nuclear receptor subfamily 1 group D member 1(REV-ERBalpha (显示 NR1D1 ELISA试剂盒)) plays an inhibitory role in the expression of prostaglandin-endoperoxide synthase 2(PTGS2 (显示 PTGS2 ELISA试剂盒)) in both bovine USCs and UECs treated with ovarian steroids
This study showed that neutrophils from periparturient heifers show impairment of COX-2 (显示 PTGS2 ELISA试剂盒) mRNA expression and lactoferrin (显示 LTF ELISA试剂盒), suggesting that these mechanisms may contribute to immunosuppression in cows around calving.
Exposure to follicular fluid transiently increased the transcript levels of IL8 (显示 IL8 ELISA试剂盒) and PTGS2 (显示 PTGS2 ELISA试剂盒), and decreased the expression of SOD2 (显示 SOD2 ELISA试剂盒), GPX3 (显示 GPX3 ELISA试剂盒), DAB2 (显示 DAB2 ELISA试剂盒), and NR3C1 (显示 NR3C1 ELISA试剂盒). TNF (显示 TNF ELISA试剂盒) and IL6 (显示 IL6 ELISA试剂盒) levels were also decreased while those of NAMPT (显示 NAMPT ELISA试剂盒) were unaffected.
Purinergic P2Y1 receptor (显示 P2RY1 ELISA试剂盒) signaling mediates wound stimuli-induced cyclooxygenase-2 (显示 PTGS2 ELISA试剂盒) expression in intestinal subepithelial myofibroblasts
Data suggest that Escherichia coli infections (here, administration of LPS (显示 IRF6 ELISA试剂盒)) provokes luteolysis in diestrus, non-lactating cows but no change in expression of PTGS2 (显示 PTGS2 ELISA试剂盒) in corpus luteum and has no effect on luteinization in the following cycle.
Data indicate that the proton-pumping pathway of heart cytochrome c (显示 CYCS ELISA试剂盒) oxidase includes a hydrogen-bond network and a water channel (显示 AQP4 ELISA试剂盒) located in tandem between the positive and negative side of the mitochondrial membrane.
Study suggests that His503 is involved in the proton supply to the D-path as a proton acceptor in cytochrome c (显示 CYCS ELISA试剂盒) oxidase.
Data suggest that the axial Met residue moderately increased the redox potential of the Cu(A) site in cytochrome c (显示 CYCS ELISA试剂盒) oxidase.
Studies indicate that heart cytochrome c (显示 CYCS ELISA试剂盒) oxidase subunits I, II and III are encoded by the mitochondrial genome.
Pretreatment of cells with selective COX-2 blocker etodolac markedly inhibited ICl.
Safflower injection may attenuate lung ischemia/reperfusion injury through inhibiting cyclooxygenase-2 (显示 PTGS2 ELISA试剂盒) expression.
The RNA interference targeting COX-2 can effectively inhibit the expression of COX-2 and MMP-2 (显示 MMP2 ELISA试剂盒) in IL-1alpha stimulated rabbit corneal stromal cells in vitro.
Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes the inducible isozyme. It is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis.
PGH synthase 2
, PHS II
, cyclooxygenase 2b
, prostaglandin G/H synthase 2
, prostaglandin H2 synthase 2
, cyclooxygenase 2
, glucocorticoid-regulated inflammatory cyclooxygenase
, macrophage activation-associated marker protein P71/73
, cytochrome c oxidase subunit II
, cytochrome c oxidase subunit ii
, cytochrome C oxidase subunit II