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抗Human ATG12 抗体:
抗Rat (Rattus) ATG12 抗体:
抗Mouse (Murine) ATG12 抗体:
Human Polyclonal ATG12 Primary Antibody for IF, IHC (p) - ABIN388536
Lum, DeBerardinis, Thompson: Autophagy in metazoans: cell survival in the land of plenty. in Nature reviews. Molecular cell biology 2005
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Human Polyclonal ATG12 Primary Antibody for WB - ABIN541666
Kamada, Funakoshi, Shintani, Nagano, Ohsumi, Ohsumi: Tor-mediated induction of autophagy via an Apg1 protein kinase complex. in The Journal of cell biology 2000
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Polyclonal ATG12 Primary Antibody for ELISA, WB - ABIN539588
Suzuki, Kirisako, Kamada, Mizushima, Noda, Ohsumi: The pre-autophagosomal structure organized by concerted functions of APG genes is essential for autophagosome formation. in The EMBO journal 2001
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Human Polyclonal ATG12 Primary Antibody for IHC (p), WB - ABIN541665
Gozuacik, Kimchi: Autophagy as a cell death and tumor suppressor mechanism. in Oncogene 2004
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Human Polyclonal ATG12 Primary Antibody for ICC, IF - ABIN4282070
Chang, Bijian, Qiu, Su, Saad, Dahabieh, Miller, Alaoui-Jamali: Endosomal sorting and c-Cbl targeting of paxillin to autophagosomes regulate cell-matrix adhesion turnover in human breast cancer cells. in Oncotarget 2017
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Human Monoclonal ATG12 Primary Antibody for IF, IHC (p) - ABIN387794
Xia, Zhang, Chen, Zhang, Liu, Jin, Ma, Ma, Yuan: Control of basal autophagy by calpain1 mediated cleavage of ATG5. in Autophagy 2010
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Human Monoclonal ATG12 Primary Antibody for ICC, IF - ABIN4254845
Bechor, Nachmias, Elia, Haim, Vatarescu, Leikin-Frenkel, Gericke, Tarnovscki, Las, Rudich: Adipose tissue conditioned media support macrophage lipid-droplet biogenesis by interfering with autophagic flux. in Biochimica et biophysica acta 2017
Bacteria Polyclonal ATG12 Primary Antibody for ELISA, WB - ABIN153489
Romanov, Walczak, Ibiricu, Schüchner, Ogris, Kraft, Martens: Mechanism and functions of membrane binding by the Atg5-Atg12/Atg16 complex during autophagosome formation. in The EMBO journal 2012
Human Polyclonal ATG12 Primary Antibody for IF (p), IHC (p) - ABIN752518
Song, Kou, Zou, Gao, Zeng, Xie: Involvement of autophagy in tri-ortho-cresyl phosphate- induced delayed neuropathy in hens. in Neurochemistry international 2013
Human Polyclonal ATG12 Primary Antibody for IHC, ELISA - ABIN1001830
Hanada, Noda, Satomi, Ichimura, Fujioka, Takao, Inagaki, Ohsumi: The Atg12-Atg5 conjugate has a novel E3-like activity for protein lipidation in autophagy. in The Journal of biological chemistry 2007
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These results suggested that ATG12 expression quantitative trait loci SNP rs26537 might contribute to an allele-specific effect on the expression of host gene ATG12 and explain a fraction of head and neck squamous cell carcinoma genetic susceptibility.
this study identified a novel mechanism by which oncogenic RAS promotes survival of malignant intestinal epithelial cells. This mechanism is driven by RAS-dependent loss of ATG12 in these cells.
miR-23a downregulation modulates the inflammatory response by targeting ATG12-mediated autophagy.
the role of the autophagy elongation complex (ATG5-12/16L1) in Hepatitis C virus replication and membranous web formation, was examined.
Ambra1 plays an important role in regulating the sensitivity of breast cancer cells to epirubicin. Regulatory effect of Ambra1 on epirubicin sensitivity is achieved through the regulation of autophagy by targeting ATG12.
The finding that miR378 targets ATG12 indicated that miR378 may have a potential role in autophagy. These findings may provide novel insights into the mechanism of metastasis in cervical cancer and a novel therapeutic target for the treatment of cervical cancer.
Results show that ATG12 is a downstream effector in MALAT1-mediated autophagy in gastric cancer cells.
HBV gained access to Atg5-12/16L1 via interaction of its core protein with the Atg12 moiety of the complex. In contrast, subsequent autophagosome maturation and closure events were unnecessary for HBV replication, as evidenced by inhibition of Atg8/LC3 conjugation. Interfering with the HBV/Atg12 cross talk may be a tool for virus control.
transcriptional activity of ATG12 gene promoter was not significantly affected by other two DNA sequence variants identified in Parkinson's disease patient
STAT3 and ATG12 are targets of miR-454-3p.
above findings suggest that ATG5-ATG12 positively regulate anti-viral NF-kappaB and IRF3 signaling during FMDV infection, thereby limiting FMDV proliferation. FMDV has evolved mechanisms to counteract the antiviral function of ATG5-ATG12, via degradation of them by viral protein 3C(pro).
rs26538 was relevant to the lower risk of coal workers' pneumoconiosis and conferred to reduce the transcription activity of ATG12's promoter.
ATG5-ATG12 is increased in hepatitis B virus-associated hepatocellular carcinoma and has a role in apoptosis
Analysis of hepatitis B virus capsid maturation steps revealed that Rab33B and Atg5/12/16L1 are required for proper particle assembly and/or stability.
reveal a novel interconnection between autophagy, proteasome activity, and cell death mediated by the ubiquitin-like properties of ATG12
The results revealed that the expression of Atg12 and LC3 II/LC3 I in the chondrocytes treated with TXC increased, compared to that in the untreated chondrocytes
Cav-1 competitively interacts with the ATG12-ATG5 system to suppress the formation and function of the latter in lung epithelial cells.
ATG12 is a novel determinant of breast cancer primary resistance to HER1/2-targeted therapeutics.
study to identify role of conjugation between ATG12 and ATG5 in LC3 lipidation; structural and mutational analyses of ATG12~ATG5-ATG16N revealed the conjugation generates a patch across ATG12 and ATG5 required for E3 activity
These data relate LC3B, ATG5 and ATG12 to mitochondrial quality control after oxidative damage, and to cellular longevity.
Axonal development is compromised in brains of mir505 knockout mice, in which autophagy signaling and formation of autophagosomes are consistently enhanced. miR505 acts via targeting Atg12.
miR-30b inhibited autophagy to alleviate hepatic ischemia-reperfusion injury by decreasing the Atg12-Atg5 conjugate.
Although genetic deletion of either Atg12 or Atg5 renders POMC neurons autophagy-deficient, mice lacking Atg5 in POMC neurons do not exhibit these phenotypes.
ATG12-ATG3 interacts with Alix to promote basal autophagic flux and late endosome function.
Atg5-Atg12/Atg16L1 protein complex is required for IFNgamma-mediated host defense against murine norovirus infection.
Vaccinia virus actively disrupts the cellular autophagy through a novel molecular mechanism that is associated with aberrant LC3 lipidation and a direct conjugation between ATG12 and ATG3.
Despite forming the Atg12-Atg5-Atg16L2 complex, Atg16L2 is not recruited to phagophores and is mostly present in the cytosol.
Autophagy participated the process of immune response of anti-MTB. Atg12 were the important molecule which control the formation of autophagy when MTB infected.
Overexpression of Atg5 or Atg12 resulted in Atg5-Atg12 conjugate formation and suppression of RNA-mediated signaling.
Autophagy is a process of bulk protein degradation in which cytoplasmic components, including organelles, are enclosed in double-membrane structures called autophagosomes and delivered to lysosomes or vacuoles for degradation. ATG12 is the human homolog of a yeast protein involved in autophagy (Mizushima et al., 1998
ATG12 autophagy related 12 homolog
, Apg12 (autophagy, yeast) homolog
, ubiquitin-like protein ATG12
, autophagy-related 12
, autophagy-related protein 12
, autophagy protein
, autophagy associated protein Atg12
, Autophagy-related protein 12
, ATG12 autophagy related 12 homolog (S. cerevisiae)
, potential preautophagosome nucleating protein Atg12
, Autophagy-related protein 12 (Autophagy-related ubiquitin-like modifier ATG12)