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These results imply that disorder in the N-terminal helices of 14-3-3 zeta is a consequence of the dimer-monomer dynamics and may play a role in conferring chaperone function to 14-3-3 zeta protein.
Knockdown of YWHAZ inhibited cell cycle progression, migration, and the expression of stem cell markers and tumorigenicity was suppressed in tumor-bearing BALB/c nude mice. The expression of YWHAZ was directly down-regulated by miR (显示 MLXIP 蛋白)-30e in resistant ovarian cancer cells.
our data suggest miR (显示 MLXIP 蛋白)-204 and 14-3-3zeta as potential therapeutic targets in osteosarcoma
evidence is lacking to conclude that 14-3-3zeta is a useful marker of tamoxifen resistance.
TRIM21 (显示 TRIM21 蛋白) positively regulated osteosarcoma cell proliferation. Overexpression of TRIM21 (显示 TRIM21 蛋白) enhanced osteosarcoma cell tolerance toward various stresses. YWHAZ protein was identified as a novel interacting partner of TRIM21 (显示 TRIM21 蛋白) and its expression levels were negatively regulated by TRIM21 (显示 TRIM21 蛋白).
several disordered regions of PI4KB (显示 PI4KB 蛋白) become protected from proteolytical degradation upon 14-3-3 (显示 YWHAQ 蛋白) binding.
Ectopic expression of miR (显示 MLXIP 蛋白)-451 could inhibit the cell migration and invasion, promoted apoptosis, induced cell-cycle arrest Furthermore, tyrosine3-monooxygenase/tryptophan5-monooxygenase activation protein zeta (YWHAZ) was identified as a direct target of miR (显示 MLXIP 蛋白)-451
Serum autoantibodies to YWHAZ are produced at substantially greater levels in gastric cancer patients as compared to controls.
Dimerization of 14-3-3 zeta (14-3-3zeta) dimer was disrupted by a double mutant (L12E, M78K).
Results identified YWHAZ as the direct target of miR (显示 MLXIP 蛋白)-613 in hepatocellular carcinoma (HCC (显示 FAM126A 蛋白)). Its overexpression reverses the tumor suppressing role of miR (显示 MLXIP 蛋白)-613 in HCC (显示 FAM126A 蛋白) cells.
The expression of zeta isoforms of 14-3-3 protein (显示 YWHAE 蛋白) was identified at substantial levels in the first instar larva, upregulated in the second instar larva, and the highest levels were maintained in the late stage of larva, the pupa, and the adult.
Caspase-2 (显示 CASP2 蛋白) phosphorylated at S135 binds 14-3-3zeta, thus preventing C2 dephosphorylation.
identification of 14-3-3zeta as a novel phosphocofilin binding protein involved in the maintenance of the cellular phosphocofilin pool
DEX can increase IOP in mouse eyes and concurrently downregulate 14-3-3 zeta protein expression in mouse TM
These results demonstrate that miR (显示 MLXIP 蛋白)-146a enhances class switch and secretion of IgE in B cells by upregulating 14-3-3sigma expression, and suggest that miR (显示 MLXIP 蛋白)-146a may be a potential target for asthma therapy.
When taken together these findings demonstrate novel roles of 14-3-3zeta in the regulation of glucose homeostasis and suggest that modulating 14-3-3zeta levels in intestinal L cells may have beneficial metabolic effects through GLP-1 (显示 GCG 蛋白)-dependent mechanisms.
The data obtained from the 14-3-3epsilon/14-3-3zeta/Wnt1 (显示 WNT1 蛋白)-Cre mice strongly indicate the importance of 14-3-3 (显示 YWHAQ 蛋白) proteins in the development of melanocyte lineages.
Results indicate that HuR (显示 ELAVL1 蛋白) induces 14-3-3zeta translation via interaction with its 3' UTR and that 14-3-3zeta is necessary for stimulation of intestinal epithelial cell migration after wounding.
PKCdelta (显示 PKCd 蛋白)-mediated phosphorylation of 14-3-3zeta contributes to the nuclear retention of FOXO1 (显示 FOXO1 蛋白), even when FOXO1 (显示 FOXO1 蛋白) is phosphorylated as under non-stress conditions
analysis of phosphorylation-dependent interactions of AQP2 (显示 AQP2 蛋白) with 14-3-3theta; and -zeta
14-3-3zeta deficient mice in the BALB/c background display behavioral and anatomical defects associated with Schizophrenia-like disorder.
Ywhaz coordinates adipogenesis in visceral fat.
An essential role for 14-3-3 zeta in the regulation of macropinocytosis in macrophages upon cytokine stimulation through modulation of the localization of coronin 1.
Comparison of day 25 Meishan and white composite swine placentas by microarray expression profiling revealed a breed-specific transition expression polymorphism in YWHAZ.
Study suggests a novel mechanism of Tor regulation mediated by 14-3-3 interaction with Tctp (显示 TPT1 蛋白) and Rheb (显示 RHEB 蛋白).
The Khc73 stalk/14-3-3/NudE pathway defines a physical connection that coordinates the activities of multiple motor proteins to precisely position the spindle.
Hpo (显示 GFER 蛋白) signaling inhibited Yki (显示 YAP1 蛋白) nuclear localization and activity by phosphorylating Yki (显示 YAP1 蛋白) and both isoforms of 14-3-3, 14-3-3varepsilon and 14-3-3zeta, regulate Yki (显示 YAP1 蛋白) activity through modulating its subcellular localization.
in vivo 14-3-3zeta monomer properties and functionality
monomeric D14-3-3zeta is capable of modulating dSlo channel activity in this regulatory complex.
These observations provide the first direct evidence that a 14-3-3 protein (显示 YWHAE 蛋白) functions as a stress-induced molecular chaperone (显示 HSP90AA1 蛋白) that dissolves and renaturalizes thermal-aggregated proteins.
Results report a bona fide third functional isoform encoded by leo divergent from the other two in structurally and functionally significant areas.
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and sheep orthologs. The encoded protein interacts with IRS1 protein, suggesting a role in regulating insulin sensitivity. Several transcript variants that differ in the 5' UTR but that encode the same protein have been identified for this gene.
, 14-3-3 protein zeta/delta
, 14-3-3 protein/cytosolic phospholipase A2
, 14-3-3 zeta
, phospholipase A2
, protein kinase C inhibitor protein 1
, protein kinase C inhibitor protein-1
, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, delta polypeptide
, tyrosine 3/tryptophan 5 -monooxygenase activation protein, zeta polypeptide
, 14-3-3 protein zeta
, tyrosine 3-monooxygenase protein zeta polypeptide
, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide
, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide b
, factor activating exoenzyme S
, mitochondrial import stimulation factor S1 subunit
, 14-3-3 protein zeta a
, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide a
, tyrosine 3/tryptophan 5-monooxygenase activation protein zeta polypeptide
, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, iota polypeptide
, D14 3 3 protein
, complementation group K
, leonardo 14-3-3
, tyrosine 3-monooxygenase
, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide