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|抗原||Poly (ADP-Ribose) Polymerase 1 (PARP1) 抗体|
|抗原表位||AA 670-858 其他选择|
|适用||人, 小鼠, 大鼠 其他选择|
|标记||This PARP1 antibody is un-conjugated 其他选择|
Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
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PARP1抗体详情PARP1目标详情 使用细节 贮存及处理 图像
|原理||Rabbit IgG polyclonal antibody for Poly [ADP-ribose] polymerase 1(PARP1) detection. Tested with WB, IHC-P, ICC in Human,Mouse,Rat.|
|交叉反应 （详细）||No cross reactivity with other proteins.|
Rabbit IgG polyclonal antibody for Poly [ADP-ribose] polymerase 1(PARP1) detection. Tested with WB, IHC-P, ICC in Human,Mouse,Rat.
Gene Name: poly (ADP-ribose) polymerase 1
Protein Name: Poly [ADP-ribose] polymerase 1
|纯化方法||Immunogen affinity purified.|
|免疫原||E.coli-derived human PARP recombinant protein (Position: Q670-R858). Human PARP shares 94% and 95% amino acid (aa) sequence identity with mouse and rat PARP, respectively.|
PARP1目标详情PARP1抗体详情 使用细节 贮存及处理 图像 回页首
|别名||PARP1 (PARP1 Antibody 摘要)|
Poly [ADP-ribose] polymerase 1 (PARP1), also known as ADPRT or PPOL is an enzyme that in humans is encoded by the PARP1 gene. PARP1 gene is mapped to 1q42.12. This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.
Synonyms: ADP ribosyltransferase (NAD+, poly (ADP ribose) polymerase) antibody|ADP ribosyltransferase diphtheria toxin like 1 antibody|ADP ribosyltransferase NAD(+) antibody|ADP ribosyltransferase NAD+ antibody|ADPRT 1 antibody|ADPRT antibody|ADPRT1 antibody|ARTD1 antibody|msPARP antibody|NAD(+) ADP ribosyltransferase 1 antibody|NAD(+) ADP-ribosyltransferase 1 antibody|pADPRT 1 antibody|pADPRT1 antibody|PARP 1 antibody|PARP antibody|PARP-1 antibody|PARP1 antibody|PARP1_HUMAN antibody|Poly (ADP ribose) polymerase 1 antibody|poly (ADP ribose) polymerase family, member 1 antibody|Poly [ADP-ribose]polymerase 1 antibody|Poly adenosine diphosphate ADP ribose polymerase antibody|Poly ADP ribose polymerase 1 antibody|Poly ADP ribose polymerase family member 1 antibody|Poly ADP ribose synthetase 1 antibody|Poly(ADP ribose) polymerase antibody|poly(ADP ribose) synthetase antibody|poly(ADP ribosyl)transferase antibody|Poly[ADP ribose] synthetase 1 antibody|Poly[ADP-ribose] synthase 1 antibody|PPOL antibody
|途径||Apoptosis, Caspase Cascade in Apoptosis, DNA Damage Repair, Production of Molecular Mediator of Immune Response, Maintenance of Protein Location|
使用细节PARP1抗体详情 PARP1目标详情 贮存及处理 图像 回页首
WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Mouse, Rat, The detection limit for PARP is approximately 0.25 ng/lane under reducing conditions.
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Mouse, Rat, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
ICC: Concentration: 0.5-1 μg/mL, Tested Species: Human
Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.
Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P) and ICC.
贮存及处理PARP1抗体详情 PARP1目标详情 使用细节 图像 回页首
|溶解方式||Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.|
|缓冲液||Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.|
|注意事项||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|注意事项||Avoid repeated freezing and thawing.|
|储存条件||4 °C/-20 °C|
At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
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