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evidence that cyclin A1-associated activity is a mediator of apoptosis and that cyclin A1/Cdk2 (显示 CDK2 蛋白) is sufficient to induce apoptosis
results suggest that cellular homeostasis of the CYCA1;2/TAM protein is linked to the control of nuclear sizes in trichomes and guard cells
We thus propose that a functional network composed of OSD1, CYCA1;2/TAM, and TDM controls three key steps of meiotic progression, in which OSD1 is a meiotic APC (显示 APC 蛋白)/C inhibitor.
Results propose a model that meiotic progression in Arabidopsis pollen mother cells is driven by a yet to be identified cyclin (显示 PCNA 蛋白)-CDK (显示 CDK4 蛋白) activity that is modulated by regulatory interactions between TDM1, SMG7, and TAM (CYCA1;2)
series of CYCA1;2 mutants failed to enter meiosis II and thus produced diploid spores and functional diploid gametes.
Thus, Cyclin A/Cdk1 phosphorylation primes MYPT1 for Plk1 binding. These data demonstrate cross-regulation between Cyclin A/Cdk1-dependent and Plk1-dependent phosphorylation of substrates during mitosis to ensure efficient correction of kinetochore microtubule attachment errors necessary for high mitotic fidelity.
Cyclin A1 functions as an oncogene (显示 RAB1A 蛋白) that controls proliferative and survival activities in tumourigenesis and chemoresistance of ovarian cancer.
In the bone marrow, cyclin A1 and aromatase (显示 CYP19A1 蛋白) enhanced local bone marrow-releasing factors, including androgen receptor (显示 AR 蛋白), estrogen and matrix metalloproteinase MMP9 (显示 MMP9 蛋白) and promoted the metastatic growth of prostate cancer cells
The data showed that E7 induced CCNA1 methylation by forming a complex with Dnmt1 (显示 DNMT1 蛋白) at the CCNA1 promoter, resulting in the subsequent reduction of expression in cancers.
DNA methylation (显示 HELLS 蛋白) status of key cell-cycle regulators such as CDKNA2/p16 and CCNA1 correlates with treatment response to doxorubicin and 5-fluorouracil in locally advanced breast tumors.
These data from results indicated a significant connection of CCNA1 methylation with poor progression in human malignant tumors among both Caucasian and Asian populations.
Cyclin A1 immunoexpression is of potential utility in predicting disease progression in patients with pT1 urothelial carcinomas of the bladder
HS3ST2 (显示 HS3ST2 蛋白) and CCNA1 genes may play important roles in HPV-induced cervical cancer and patients with specific hypermethylated genes may have a greater risk of progressing to invasive cervical cancer.
CCNA1 promoter methylation is associated with cervical squamous intraepithelial lesions.
High CCNA1 expression is associated with nasopharyngeal carcinoma.
wild type control, 14-3-3 (显示 YWHAQ 蛋白) is detected in both cytosolic and nuclear fractions whereas it is restricted to the cytoplasm in mutant testes. This differential distribution of 14-3-3 (显示 YWHAQ 蛋白) may contribute to the induction of apoptosis in Ccna1-deficient spermatocytes
cyclin A1 in association with vascular endothelial growth factor receptor 1 (VEGFR1 (显示 FLT1 蛋白)), is required for HSPC (显示 PSMA7 蛋白) and their niches to maintain their function and proper interaction
Neither overexpression nor loss of cyclin A1 significantly altered leukemogenesis in PML (显示 PML 蛋白)-RARalpha (显示 RARA 蛋白)-knockin mice.
With the recent data on the functions of cyclins in somatic and stem cells, we also discussed the possibilities of further studies of cyclin A1 in mouse oocytes and perhaps in the oogonial stem cells
Sp1 (显示 SP1 蛋白) and possibly GATA1 (显示 GATA1 蛋白) bind concomitantly to the Ccna1 promoter and suppress its activity in vivo.
CIZ1 (显示 CIZ1 蛋白) interacts with germ-cell-specific cyclin A1.
Analysis of Ccna1 transgene expression indicated that sequences within -1.3 kilobases (kb) of the cyclin A1 putative transcriptional start site were sufficient to direct transgene expression uniquely to late spermatocytes.
decreased expression of Ccna1 mRNA and the accumulation of SCP3 (显示 SYCP3 蛋白)-positive spermatocytes showed the arrest of spermatogenesis at the pachytene stage in the Dmrt7 (显示 DMRTC2 蛋白)-knockout mice.
Mip/LIN-9 (显示 LIN9 蛋白) is required for the expression of B-Myb (显示 MYBL2 蛋白), and both proteins collaborate in the control of the cell cycle progression via the regulation of S phase and cyclin A (显示 CCNA2 蛋白), cyclin B, and CDK1 (显示 CDK1 蛋白)
cyclin A1 has a critical role in the pericentromeric region in late diplotene of meiosis, perhaps in assembly or function of the passenger protein complex
The results showed that cyclin A (显示 CCNA2 蛋白) overexpression suppressed porcine circovirus type 2 replication.
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. The cyclin encoded by this gene was shown to be expressed in testis and brain, as well as in several leukemic cell lines, and is thought to primarily function in the control of the germline meiotic cell cycle. This cyclin binds both CDK2 and CDC2 kinases, which give two distinct kinase activities, one appearing in S phase, the other in G2, and thus regulate separate functions in cell cycle. This cyclin was found to bind to important cell cycle regulators, such as Rb family proteins, transcription factor E2F-1, and the p21 family proteins. Multiple transcript variants encoding different isoforms have been found for this gene.
, cyclin A1