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Human Caspase 8 Protein expressed in Escherichia coli (E. coli) - ABIN2487286
Appukuttan, Kasseckert, Micoogullari, Flacke, Kumar, Woste, Abdallah, Pott, Reusch, Ladilov: Type 10 adenylyl cyclase mediates mitochondrial Bax translocation and apoptosis of adult rat cardiomyocytes under simulated ischaemia/reperfusion. in Cardiovascular research 2012
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Human Caspase 8 Protein expressed in Escherichia coli (E. coli) - ABIN2688834
Nicholson, Ali, Thornberry, Vaillancourt, Ding, Gallant, Gareau, Griffin, Labelle, Lazebnik: Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. in Nature 1995
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Furthermore, while activities to process procaspase-8 and procaspase-9 appeared in SAMDC (显示 AMD1 蛋白)-overexpressed apoptotic embryos, the activity to process procaspase-8 did not appear in p53 (显示 TP53 蛋白)-overexpressed apoptotic embryos.
tail regression at metamorphosis implicates an apoptotic pathway inducible by T(3) hormone in an organ autonomous manner and involving the cell death executioners BH3 interacting domain death agonist (显示 BID 蛋白) and Caspases-2 and -8
These data demonstrate that caspase-8 functions in synovial antigen-presenting cells to regulate the response to inflammatory stimuli by controlling RIPK3 (显示 RIPK3 蛋白) action, and this delicate balance maintains homeostasis within the joint.
Results illustrate the temporal and spatial activation of caspase-8 and -3 in microglia/macrophages occurring upon ischemic stroke and suggest that the expression of these caspases could be used in neuropathological diagnostic work.
inhibition of TAK1 (显示 NR2C2 蛋白) triggered two caspase 8 activation pathways through the induction of RIP1 (显示 RALBP1 蛋白)-FADD (显示 FADD 蛋白)-caspase 8 complex as well as FLIP cleavage/degradation.
this study identifies a crucial role for caspase-8 in the development of allergic airway inflammation
Prolonged treatment of human PMNs or mice bone marrow derived neutrophils (BMDN) with nitric oxide led to enhanced reactive oxygen species generation, caspase-8/caspase-3 (显示 CASP3 蛋白) cleavage, reduced mitochondrial membrane potential and finally cellular apoptosis.
caspase-8-dependent apoptosis was linked to hepatocellular carcinoma development.
Statistically significant increases in the expression of Fas (显示 FAS 蛋白) and caspase-8 were observed, along with other molecules involved in the extrinsic apoptotic pathway such as Dapk1 (显示 DAPK1 蛋白), Traf3 (显示 TRAF3 蛋白), Tnsf12, Tnfrsf1A (显示 TNFRSF1A 蛋白) and Ripk1 (显示 RIPK1 蛋白).
Results suggest that caspase-8 could regulate receptor-interacting protein 3 (RIP3 (显示 RIPK3 蛋白))-mediated necroptosis.
we show that caspase-8 activity promotes cell-intrinsic cytokine expression, independent of its role in cell death in response to Yersinia infection
Data indicate that NLRC4 (显示 NLRC4 蛋白) activation in Intestinal epithelial cells (IECs) leads to cell expulsion and IL-18 (显示 IL18 蛋白) release, and implicate Caspase-8 in NLRC4 (显示 NLRC4 蛋白) inflammasome responses in vivo by generation of doubly deficient in Caspase-1 (显示 CASP1 蛋白) and Caspase-8.
High CASP8 expression is associated with Colorectal Cancer.
Sleep duration is associated with plasma caspase-8. Caspase-8 independently predicts diabetes mellitus years before disease onset and modifies the effect of sleep duration on incident diabetes mellitus.
Caspase-8 and Caspase-3 (显示 CASP3 蛋白) expressions in tumor tissues are novel candidate prognostic markers for colorectal cancer patients
Reactive oxygen species-induced cleavage of NHLRC2 by caspase-8 leads to apoptotic cell death in the HCT116 human colon cancer cells.
this study is the first report on reduced expression of CASP8 in breast cancer versus adjacent normal tissues.
The polymorphisms of CASP8, rs7608692, and haplotype AGAACAG correlated with neutropenia toxicity. The haplotype GGGGAAA was associated with thrombocytopenia toxicity. We conclude that the polymorphisms of CASP8 contribute to the prognosis of advanced lung adenocarcinoma and influence the quality of life and survival.
These results indicated that cMyc (显示 MYC 蛋白) and Fas (显示 FAS 蛋白) regulated the sensitivity of A549 cells to irradiation by regulating caspase8-mediated Bid (显示 BID 蛋白) activation and the subsequent association with the mitochondrial pathway of apoptosis.
The caspase-8/Bid (显示 BID 蛋白)/cytochrome c (显示 CYCS 蛋白) axis links signals from death receptors to mitochondrial reactive oxygen species production.
miR (显示 MLXIP 蛋白)-21 was elevated in osteosarcoma, and overexpression of miR (显示 MLXIP 蛋白)-21 suppressed apoptosis via targeting caspase 8.
Our findings indicate the relationship of SNP CASP8 D302H and breast cancer would not be universal but only be sensitive in some particular European countries.
S. aureus-induced apoptosis in bovine mammary epithelial cells apoptosis was mitigated by caspase-3 (显示 CASP3 蛋白) and caspase-8 inhibitors, suggesting that apoptosis is initiated via caspase-8 activation.
Endothelial cell apoptosis by H. somnus-activated platelets required activation of both caspase-8 and caspase-9 (显示 CASP9 蛋白).
Nitric oxide-dependent increase in caspase-8 mRNA levels is associated with phosphorylation of STAT-1 (显示 STAT1 蛋白) at Ser (显示 SIGLEC1 蛋白)-727 and STAT1 (显示 STAT1 蛋白) binding to the caspase-8 promoter in cultured lung endothelial cells.
Data show that cysteine significantly reduced the expression of pro-inflammatory cytokines, including TNF-alpha (显示 TNF 蛋白), IL-6 (显示 IL6 蛋白), IL-12p40, IL-1beta (显示 IL1B 蛋白), and resulted in increased expression of the apoptosis initiator caspase-8 and bcl2L1 (显示 BCL2L1 蛋白).
Induction of apoptosis through targeted activation of caspase (显示 CASP3 蛋白) by tamoxifen (ATTAC(TM)) further expands the repertoire of genetic tools for conditional interrogation of cellular functions.
Targeted gene knockdown of TNFRSF1B (显示 TNFRSF1B 蛋白) in zebrafish embryos results in the induction of a caspase-8, caspase-2 (显示 CASP2 蛋白) and P53 (显示 TP53 蛋白)-dependent apoptotic program in endothelial cells that bypasses caspase-3 (显示 CASP3 蛋白).
These results show that zebrafish casp8 has a structure and function similar to mammalian CASP8 orthologs and the role of caspase-8 in the apoptotic signal pathway has been conserved over at least 450 million years of vertebrate evolution.
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined.
, xcaspase 8
, death related ced-3/Nedd2-like protein
, caspase 8, apoptosis-related cysteine peptidase
, caspase 8
, DEATH effector domain caspase
, Fas-linked ICE-like protease
, FADD-homologous ICE/CED-3-like protease
, FADD-like ICE
, ICE-like apoptotic protease 5
, MACH-alpha-1/2/3 protein
, MACH-beta-1/2/3/4 protein
, MORT1-associated ced-3 homolog
, apoptotic cysteine protease
, apoptotic protease Mch-5
, caspase 8, apoptosis-related cysteine protease
, cysteine protease