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Human Caspase 6 Protein expressed in Escherichia coli (E. coli) - ABIN2487275
Basu, Lu, Sun, Moor, Akkaraju, Huang: Proteolytic activation of protein kinase C-epsilon by caspase-mediated processing and transduction of antiapoptotic signals. in The Journal of biological chemistry 2002
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Caspase-6 is posttranslationally palmitoylated by the palmitoyl acyltransferase HIP14 (显示 ZDHHC17 蛋白) and that the palmitoylation of Caspase-6 inhibits its activation.
The bactericidal activity of caspase-6-/- macrophages was impaired compared to wild type cells. Caspase-6-/- mice showed higher expression of the IL-1b (显示 IL1B 蛋白) gene, known to be detrimental in murine melioidosis. Expression of the IL-10 (显示 IL10 蛋白) gene was also increased in caspase-6-/- mice as early as 6 hours after infection. Treatment with exogenous IL-10 (显示 IL10 蛋白) rendered mice more susceptible against B. pseudomallei challenge
caspase-6 could regulate breast cancer cell invasion by modulating MMP-2 (显示 MMP2 蛋白) and MMP-9 (显示 MMP9 蛋白) expression in 4T1 tumor-associated macrophages
Casp6 is unlikely to be involved in colitis-associated tumors.
p53 (显示 TP53 蛋白) activity is an important upstream regulator of caspase-6 activity in muscle tissue.
TNFalpha (显示 TNF 蛋白)-induced RIP1 (显示 RALBP1 蛋白)-independent caspase-6 activation was involved in regulating the relationship between autophagy and necroptosis.
CASP6 released from axonal terminals regulates microglial TNF-alpha (显示 TNF 蛋白) secretion, synaptic plasticity, and inflammatory pain.
both Caspase-3 (显示 CASP3 蛋白) and Caspase-6 are implicated in axon degeneration that occurs as a part of normal development.
Casp6-/- neurons are protected against excitotoxicity, nerve growth factor deprivation and myelin-induced axonal degeneration. Furthermore, Casp6-deficient mice show an age-dependent increase in cortical and striatal volume.
This study demonistrated that elimination of caspase-6 protein and activity in the BACHD mouse model does not prevent the production of a 586 aa Htt (显示 HTT 蛋白) proteolytic fragment in the brain.
The prodomain region was found to be intrinsically disordered independent of the activation state of caspase-6; however, its complete removal resulted in the protection of the adjacent 26-32 region, suggesting that this region may play a regulatory role. The molecular details of caspase-6 dynamics in solution provide a comprehensive scaffold for strategic design of therapeutic approaches for neurodegenerative disorders.
SMSr is a novel and specific substrate of caspase-6, a non-conventional effector caspase (显示 CASP3 蛋白) implicated in Huntington's and Alzheimer's diseases.
Results support the possibility that the Casp6 activity in the anterior olfactory nucleus of the olfactory bulb reflects degeneration in the entorhinal cortex and suggest that Casp6 activity in the olfactory bulb could represent degeneration associated with cognitive decline and early Alzheimer disease.
These data suggest that caspase-6 deactivating mutations may contribute to multifactorial carcinogenic transformations.
Caspase-6 undergoes helix-strand transition upon substrate binding. Caspase-6 shows distinctive conformational dynamics in its 130's region Local pKa Values of Key Amino Acid Residues within the 130's Region Vary between the Unliganded (Helical) and the VEID-bound (Strand) States of Caspase-6 .
Following specific binding to and internalization into HER2 (显示 ERBB2 蛋白)-overexpressing tumor cells, the e23sFv-Fdt-casp6 protein induced tumor cell apoptosis and inhibited the proliferation of HER2 (显示 ERBB2 蛋白)-overexpressing A172 and U251MG cells in vitro, but not in U87MG cells with undetectable HER2 (显示 ERBB2 蛋白)
Results identified novel members of the CASP6 interactome and demonstrate that a number of them are involved in key signaling pathways observed in neurodegenerative diseases.
The ability of sox11 (显示 SOX11 蛋白) to reduce effector caspase (显示 CASP3 蛋白) activity was also reflected in its capacity to reduce cell death following toxic insult. Interestingly, other sox (显示 PIPOX 蛋白) proteins also had the ability to reduce caspase-6 activity but to a lesser extent than sox11 (显示 SOX11 蛋白)
Caspase-6 plays a role in activating caspase-3 (显示 CASP3 蛋白) in Tau truncation.
unmodified STAT1 (显示 STAT1 蛋白) is cleaved at multiple sites by caspase-3 (显示 CASP3 蛋白) and caspase-6 in malignant undifferentiated hematopoietic cells
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade. Alternative splicing of this gene results in two transcript variants that encode different isoforms.
, caspase 6, apoptosis-related cysteine protease
, caspase 6
, apoptotic protease Mch-2
, apoptotic protease MCH-2