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BIR3 interacts with BAK1 and inhibits ligand binding receptors to prevent BAK1 receptor complex formation.
The role of BAK1 in defense against root-knot nematode and pattern-triggered immunity
N-glycosylation and specific ERQC components are essential to activate bak1/serk4 cell death, and CRK4 is likely to be among client proteins of protein glycosylation involved in BAK1/SERK4-regulated cell death.
BAK1 and SOBIR1 associate with each other in planta when the function of BIR1 (显示 KCNJ6 蛋白) is compromised.
an allosteric mechanism for inhibition of BAK1 by C408 S-glutathionylation
Study identifies a link between plant perception of biotic threats by BAK1, cellular calcium entry mediated by GLRs, and intracellular calcium release by TPC1 (显示 TPCN1 蛋白) during a biologically relevant interaction.
The Arabidopsis Malectin (显示 MLEC 蛋白)-Like/LRR-RLK (显示 TXK 蛋白) IOS1 Is Critical for BAK1-Dependent and BAK1-Independent Pattern-Triggered Immunity
These findings show that BAK1 contains an additional AtRALF1 binding site, indicating that this protein may be part of a AtRALF1-containing complex as a co-receptor, and it is required for the negative regulation of cell expansion
the existence of partial redundancy between SERK3 and SERK1 as well as the promoting or repressive activity of a single coreceptor in multiple simultaneously active pathways, is reported.
The found that in an otherwise "active" BAK1 the alphaC helix is highly disordered, a hallmark of deactivation, whereas the BRI1 alphaC helix is moderately disordered and displays swinging behavior similar to numerous animal kinases.
interleukin-6 (显示 IL6 蛋白), endothelin ET-1 (显示 EDN1 蛋白), and apoptotic Bak and Bcl-XL (显示 BCL2L1 蛋白) genes have roles in small bowel transplantation, in a swine model of ischemia and reperfusion injury
Bak mRNA was significantly increased in haploid parthenotes compared with the diploid parthenotes. These results suggest that the haploid state affects apoptosis-related gene expression which results in increased apoptosis
This comprehensive survey showed that in each Bak dimer the N-termini are fully solvent-exposed and mobile, the core is highly structured, and the C-termini are flexible but restrained by their contact with the membrane.
The BAK1/BCL2 (显示 BCL2 蛋白) ratio was positively correlated with the results of audiometric tests. Our results indicate that BAK-mediated apoptosis may be a core mechanism in the progression of age-related hearing impairment in humans
UMI-77 enhances TRAIL-induced apoptosis by unsequestering Bim (显示 BCL2L11 蛋白) and Bak, which provides a novel therapeutic strategy for the treatment of gliomas.
after the induction of apoptosis, Bak switches from its association with Mtx2 (显示 MTX2 蛋白) and VDAC2 (显示 VDAC2 蛋白) to a closer association with Mtx1 (显示 MTX1 蛋白).
Conversion of Bim (显示 BCL2L11 蛋白)-BH3 from Activator to Inhibitor of Bak through Structure-Based Design.
The results strongly suggest that the direct apoptosis-activation activities of Bid (显示 BID 蛋白), Bim (显示 BCL2L11 蛋白), Puma (显示 BBC3 蛋白), and p53 (显示 TP53 蛋白) are not essential for activating Bax (显示 BAX 蛋白)/Bak once the anti-apoptotic Bcl-2 (显示 BCL2 蛋白) proteins are neutralized.
Studied BAK1, SPRY4 (显示 SPRY4 蛋白) and GAB2 (显示 GAB2 蛋白) SNPs in pediatric germ cell tumors(GCT (显示 QPCT 蛋白)); found a variant in SPRY4 (显示 SPRY4 蛋白) was associated with reduced risk of GCT (显示 QPCT 蛋白); a variant in BAK1 was positively associated with GCT (显示 QPCT 蛋白) with a strong estimated effect for testis tumors; and a SNP in GAB2 (显示 GAB2 蛋白) was associated with increased risk for GCT (显示 QPCT 蛋白).
These results not only establish Bok (显示 BOK 蛋白) as a Bak- and Bax (显示 BAX 蛋白)-independent apoptosis inducer, but also suggest a potential impact of Bok (显示 BOK 蛋白) expression in ovarian cancer therapy.
The low-level constitutive production of platelets caused by the G allele of rs5745568 in BAK1 protein seems to increase the risk of bleeding in dengue infection
the expression of Bak1 was downregulated in CRC (显示 CALR 蛋白) tumor tissues and was reversely correlated with the expression of miR410, which provided further support that Bak1 was regulated by miR410.
Here the authors show that mouse embryonic fibroblasts deficient in Bax (显示 BAX 蛋白)/Bak1 are resistant to the third major form of cell death associated with autophagy through a mechanism involving lysosome permeability.
BH3-only (显示 BBC3 蛋白) proteins bind inactive full-length BAK at mitochondria and then dissociate following exposure of the BAK BH3 and BH4 domains before BAK homodimerization
Resultdetermined the mouse Bak BH3-in-groove homodimers (BGH) structure, which allowed more accurate modeling within and between the BGHs. The BGHs were shown to oligomerize via the 'alpha 3/alpha 5 interface' in mitochondria. These findings suggest for a probable assembly of the Bak homodimers in the mitochondrial apoptotic pore.
We propose that the GC-induced mitochondrial accumulation of Bax (显示 BAX 蛋白) and the interaction between the GR and Bim (显示 BCL2L11 蛋白), Bcl-xL (显示 BCL2L1 蛋白) and Bak could play a role in the regulation of thymocyte apoptosis.
Postnatal synaptic rearrangement needed for acquisition of skilled behaviors requires the activity-dependent, non-apoptotic Bax (显示 BAX 蛋白)/Bak-caspase (显示 CASP3 蛋白) signaling cascade. Adult Bax (显示 BAX 蛋白)/Bak mutant mice exhibit aberrant co-activation of antagonistic muscle pairs and skilled grasping deficits but normal reaching and retrieval behaviors.
The authors show that Bak is activated and that activated Bak is bound to p53 (显示 TP53 蛋白) during reovirus encephalitis.
Pancreatic beta-Cell Death due to Pdx-1 (显示 PDX1 蛋白) Deficiency Requires Multi-BH Domain Protein Bax (显示 BAX 蛋白) but Not Bak.
lipid profile in the absence of the proapoptotic proteins BAX (显示 BAX 蛋白) and BAK in mouse embryonic fibroblasts
alpha1 dissociation is a key step in unfolding Bak into three major components, the N terminus, the core (alpha2-alpha5) and the latch (alpha6-alpha8) that is required for apoptosis.
regulation of A1 and Bak contribute to mitochondrial membrane stability, reduced caspase-9 (显示 CASP9 蛋白) activity, and delayed apoptosis in bovine neutrophils exposed to glucocorticoids
The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein localizes to mitochondria, and functions to induce apoptosis. It interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel, which leads to a loss in membrane potential and the release of cytochrome c. This protein also interacts with the tumor suppressor P53 after exposure to cell stress.
BCL2-like 7 protein
, apoptosis regulator BAK
, bcl-2 homologous antagonist/killer
, bcl-2-like protein 7
, pro-apoptotic protein BAK
, Bcl2 homologous antagonist/killer
, Bcl-2-like 7