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The Arabidopsis Malectin (显示 MLEC 蛋白)-Like/LRR-RLK (显示 TXK 蛋白) IOS1 Is Critical for BAK1-Dependent and BAK1-Independent Pattern-Triggered Immunity
These findings show that BAK1 contains an additional AtRALF1 binding site, indicating that this protein may be part of a AtRALF1-containing complex as a co-receptor, and it is required for the negative regulation of cell expansion
the existence of partial redundancy between SERK3 and SERK1 as well as the promoting or repressive activity of a single coreceptor in multiple simultaneously active pathways, is reported.
The found that in an otherwise "active" BAK1 the alphaC helix is highly disordered, a hallmark of deactivation, whereas the BRI1 alphaC helix is moderately disordered and displays swinging behavior similar to numerous animal kinases.
These data suggest that BIK1 cooperates with BAK1 to regulate constitutive immunity and cell death.
Oligogalacturonides are sensed through multiple and partially redundant perception/transduction complexes, some targeted by AvrPto, but not necessarily comprising BAK1 and BKK1.
These results suggest that pleiotropic phenotypic alterations shown in the BAK1- overexpressing transgenic plants result from the constitutive activation of SA-mediated defense responses.
The study reveals the signaling activation mechanism in floral organ abscission by IDA-induced HAE/HSL2-SERK complex formation accompanied by transphosphorylation.
Receptor like kinases (RLP)-mediated resistance and endocytosis require ligand-induced recruitment of BAK1/SERK3, reminiscent of BAK1/SERK3 interaction and subcellular fate of the FLAGELLIN (显示 FliC 蛋白) SENSING 2 (FLS2) RLK (显示 TXK 蛋白).
G protein signaling is directly activated by the pathogen-associated molecular pattern flagellin (显示 FliC 蛋白) peptide 22 through its LRR RLK (显示 TXK 蛋白), FLS2, and co-receptor BAK1.
interleukin-6 (显示 IL6 蛋白), endothelin ET-1 (显示 EDN1 蛋白), and apoptotic Bak and Bcl-XL (显示 BCL2L1 蛋白) genes have roles in small bowel transplantation, in a swine model of ischemia and reperfusion injury
Bak mRNA was significantly increased in haploid parthenotes compared with the diploid parthenotes. These results suggest that the haploid state affects apoptosis-related gene expression which results in increased apoptosis
UMI-77 enhances TRAIL-induced apoptosis by unsequestering Bim (显示 BCL2L11 蛋白) and Bak, which provides a novel therapeutic strategy for the treatment of gliomas.
after the induction of apoptosis, Bak switches from its association with Mtx2 (显示 MTX2 蛋白) and VDAC2 (显示 VDAC2 蛋白) to a closer association with Mtx1 (显示 MTX1 蛋白).
Conversion of Bim (显示 BCL2L11 蛋白)-BH3 from Activator to Inhibitor of Bak through Structure-Based Design.
The results strongly suggest that the direct apoptosis-activation activities of Bid (显示 BID 蛋白), Bim (显示 BCL2L11 蛋白), Puma (显示 BBC3 蛋白), and p53 (显示 TP53 蛋白) are not essential for activating Bax (显示 BAX 蛋白)/Bak once the anti-apoptotic Bcl-2 (显示 BCL2 蛋白) proteins are neutralized.
Studied BAK1, SPRY4 (显示 SPRY4 蛋白) and GAB2 (显示 GAB2 蛋白) SNPs in pediatric germ cell tumors(GCT (显示 QPCT 蛋白)); found a variant in SPRY4 (显示 SPRY4 蛋白) was associated with reduced risk of GCT (显示 QPCT 蛋白); a variant in BAK1 was positively associated with GCT (显示 QPCT 蛋白) with a strong estimated effect for testis tumors; and a SNP in GAB2 (显示 GAB2 蛋白) was associated with increased risk for GCT (显示 QPCT 蛋白).
These results not only establish Bok (显示 BOK 蛋白) as a Bak- and Bax (显示 BAX 蛋白)-independent apoptosis inducer, but also suggest a potential impact of Bok (显示 BOK 蛋白) expression in ovarian cancer therapy.
The low-level constitutive production of platelets caused by the G allele of rs5745568 in BAK1 protein seems to increase the risk of bleeding in dengue infection
the expression of Bak1 was downregulated in CRC (显示 CALR 蛋白) tumor tissues and was reversely correlated with the expression of miR410, which provided further support that Bak1 was regulated by miR410.
Low expression of BAX (显示 BAX 蛋白) is associated with docetaxel resistance in gastric cancer.
Polymorphisms of KITLG (显示 KITLG 蛋白), SPRY4 (显示 SPRY4 蛋白), and BAK1 genes in patients with testicular germ cell tumors and individuals with infertility associated with AZFc deletion of the Y chromosome
Postnatal synaptic rearrangement needed for acquisition of skilled behaviors requires the activity-dependent, non-apoptotic Bax (显示 BAX 蛋白)/Bak-caspase (显示 CASP3 蛋白) signaling cascade. Adult Bax (显示 BAX 蛋白)/Bak mutant mice exhibit aberrant co-activation of antagonistic muscle pairs and skilled grasping deficits but normal reaching and retrieval behaviors.
The authors show that Bak is activated and that activated Bak is bound to p53 (显示 TP53 蛋白) during reovirus encephalitis.
Pancreatic beta-Cell Death due to Pdx-1 (显示 PDX1 蛋白) Deficiency Requires Multi-BH Domain Protein Bax (显示 BAX 蛋白) but Not Bak.
lipid profile in the absence of the proapoptotic proteins BAX (显示 BAX 蛋白) and BAK in mouse embryonic fibroblasts
alpha1 dissociation is a key step in unfolding Bak into three major components, the N terminus, the core (alpha2-alpha5) and the latch (alpha6-alpha8) that is required for apoptosis.
BAX (显示 BAX 蛋白) and BAK have a nonapoptotic role in eicosanoid metabolism in inflammation.
Puma (显示 BBC3 蛋白) is the major mediator of virus-induced Bax (显示 BAX 蛋白)/Bak activation and mitochondrial membrane permeabilization induction.
Motifs of VDAC2 (显示 VDAC2 蛋白) required for mitochondrial Bak import and tBid-induced apoptosis.
dual ablation of Bax (显示 BAX 蛋白) and Bak suppressed ureteral obstruction induced inflammation and kidney fibrosis with decreased tubular cell cycle arrest
regulation of A1 and Bak contribute to mitochondrial membrane stability, reduced caspase-9 (显示 CASP9 蛋白) activity, and delayed apoptosis in bovine neutrophils exposed to glucocorticoids
The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein localizes to mitochondria, and functions to induce apoptosis. It interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel, which leads to a loss in membrane potential and the release of cytochrome c. This protein also interacts with the tumor suppressor P53 after exposure to cell stress.
BCL2-like 7 protein
, apoptosis regulator BAK
, bcl-2 homologous antagonist/killer
, bcl-2-like protein 7
, pro-apoptotic protein BAK
, Bcl2 homologous antagonist/killer
, Bcl-2-like 7