Nucleophosmin (Nucleolar phosphoprotein B23, Numatrin) (NPM1) 抗体

ABIN969325 产品详细信息, 供应商: Log in to see
抗原
  • npm4
  • npm
  • B23
  • NPM
  • NO38
  • B23NP
  • Npm
  • CG7917
  • CRP1
  • Crp1
  • Dmel\\CG7917
  • dNLP
  • dNLP-S
  • p22
  • nucleophosmin 1
  • nucleophosmin 1b
  • Nucleophosmin
  • nucleophosmin (nucleolar phosphoprotein B23, numatrin) L homeolog
  • nucleophosmin
  • nucleophosmin (nucleolar phosphoprotein B23, numatrin)
  • Nucleoplasmin
  • NPM1
  • npm1b
  • npm
  • npm1.L
  • Npm1
  • Nlp
适用
人, 猴
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宿主
小鼠
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124
18
1
克隆类型 (克隆位点)
单克隆 ()
标记
非结合性
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9
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3
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2
应用范围
Immunocytochemistry (ICC), Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
315
172
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104
84
40
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31
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选项
Supplier
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Supplier Product No.
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免疫原 Purified recombinant fragment of human NPM (2-265) expressed in E. Coli.
克隆位点 7H10B9
亚型 IgG1
纯化方法 Ascites
别名 Nucleophosmin (NPM1 Antibody 摘要)
背景 Nucleophosmin (NPM), also named B23 or NO38, is a major nucleolar protein which is 20 times more abundant in tumor or proliferating cells than in normal resting cells. NPM has been implicated in several distinct cellular functions, including assembly and transport of ribosomes, cytoplasmic/nuclear trafficking, regulation of DNA polymerase alpha activity, centrosome duplication and molecular chaperoning activities. The NPM is also known for its fusion with the anaplastic lymphoma kinase (ALK) receptor tyrosine kinase. The NPM portion contributes to transformation by providing a dimerization domain, which results in activation of the fused kinase.
分子量 33 kDa
基因ID 4869
HGNC 4869
途径 Ribonucleoprotein Complex Subunit Organization, Ribosome Assembly
应用备注 ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000, ICC: 1:200 - 1:1000
限制 仅限研究用
状态 Liquid
缓冲液 Ascitic fluid containing 0.03 % sodium azide.
储存液 Sodium azide
注意事项 This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
储存条件 4 °C,-20 °C
储存方法 4°C, -20°C for long term storage
厂商提供的图像
Immunocytochemistry (ICC) image for anti-Nucleophosmin (Nucleolar phosphoprotein B23, Numatrin) (NPM1) antibody (ABIN969325) Figure 1: Confocal immunofluorescence analysis of Hela (left) and NTERA-2 (right) cel...
Immunohistochemistry (IHC) image for anti-Nucleophosmin (Nucleolar phosphoprotein B23, Numatrin) (NPM1) antibody (ABIN969325) Figure 2: Immunohistochemical analysis of paraffin-embedded human liver carcinoma tis...
Western Blotting (WB) image for anti-Nucleophosmin (Nucleolar phosphoprotein B23, Numatrin) (NPM1) antibody (ABIN969325) Figure 3: Western blot analysis using NPM mouse mAb against SMMC-7721 (1), HepG2 (2),...
背景 Yoneda-Kato, Look, Kirstein, Valentine, Raimondi, Cohen, Carroll, Morris: "The t(3;5)(q25.1;q34) of myelodysplastic syndrome and acute myeloid leukemia produces a novel fusion gene, NPM-MLF1." in: Oncogene, Vol. 12, Issue 2, pp. 265-75, 1996 (PubMed).

有引用在: Morris, Kirstein, Valentine, Dittmer, Shapiro, Saltman, Look: "Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma." in: Science (New York, N.Y.), Vol. 263, Issue 5151, pp. 1281-4, 1994 (PubMed).

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