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ELK1 抗体

ELK1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 7E10D5 unconjugated
产品编号 ABIN969096
发货至: 中国
  • 抗原 See all ELK1 抗体
    ELK1 (ELK1, Member of ETS Oncogene Family (ELK1))
    适用
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    宿主
    • 145
    • 10
    小鼠
    克隆类型
    • 134
    • 22
    单克隆
    标记
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    This ELK1 antibody is un-conjugated
    应用范围
    • 108
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    • 7
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    Western Blotting (WB), ELISA
    纯化方法
    purified
    免疫原
    Purified recombinant fragment of ELK1 expressed in E. coli.
    克隆位点
    7E10D5
    亚型
    IgG1
    Top Product
    Discover our top product ELK1 Primary Antibody
  • 应用备注
    ELISA: 1:10000, WB: 1:500 - 1:2000
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Ascitic fluid containing 0.03 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C/-20 °C
    储存方法
    4°C, -20°C for long term storage
  • Hsieh, Wu, Tsai, Huang, Hsieh, Liu: "PKCalpha expression regulated by Elk-1 and MZF-1 in human HCC cells." in: Biochemical and biophysical research communications, Vol. 339, Issue 1, pp. 217-25, (2005) (PubMed).

  • 抗原
    ELK1 (ELK1, Member of ETS Oncogene Family (ELK1))
    别名
    ELK1 (ELK1 产品)
    别名
    Elk-1 antibody, Xelk antibody, Xelk-1 antibody, elk-1 antibody, elk1 antibody, ELK1, ETS transcription factor antibody, ELK1, member of ETS oncogene family antibody, ETS domain-containing protein Elk-1 antibody, ELK1, member of ETS oncogene family S homeolog antibody, ELK1 antibody, Elk1 antibody, Tsp_02690 antibody, elk1 antibody, elk1.S antibody
    背景

    Description: The transcription factor ELK1 is a family of member of ETS oncogene family and of the ternary complex factor (TCF) subfamily,which is located on chromosome Xp11.2 and stimulates transcription. binds to purine-rich DNA sequences. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum reponse element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is a nuclear target for the ras-raf-MAPK signaling cascade. Elk1 is phosphorylated by MAP kinase pathways at a cluster of S/T motifs at its C terminus,It appears to be a direct target of activated MAP kinase. Biochemical studies indicate that Elk1 is a good substrate for MAP kinase, the kinetics of Elk1phosphorylation and activation correlate with MAP kinase activity, and interfering mutants of MAP kinase block Elk1 activation in vivo. More recent studies have shown that Elk1 is also a target of the Stress Activated Kinase SAPK/JNK. Phosphorylation of Elk1 has also been implicated in synaptic plasticity in the adult hippocampus.

    Aliases: ELK1

    基因ID
    2002
    HGNC
    2002
    途径
    MAPK Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades, Signaling of Hepatocyte Growth Factor Receptor, BCR Signaling
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