XRCC4 抗体 (AA 53-168)
(3 references)-
- 抗原 See all XRCC4 抗体
- XRCC4 (X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 4 (XRCC4))
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抗原表位
- AA 53-168
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This XRCC4 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunofluorescence (IF)
- 产品特性
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States. - 纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- 免疫原
- Human XRCC4 aa. 53-168
- 克隆位点
- 4-XRCC4
- 亚型
- IgG2b
- Top Product
- Discover our top product XRCC4 Primary Antibody
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anti-X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 4 (XRCC4) (AA 1-336) antibody
XRCC4 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 4 (XRCC4) (AA 1-336) antibodyXRCC4 适用: 人 WB, IF, IHC (p) 宿主: 小鼠 Polyclonal unconjugated
anti-X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 4 (XRCC4) antibodyXRCC4 适用: 人, 大鼠, 小鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 4 (XRCC4) (C-Term) antibodyXRCC4 适用: 人 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 4 (XRCC4) antibodyXRCC4 适用: 人 WB, IF, IP, IHC (p) 宿主: 小鼠 Monoclonal 8K2 unconjugated
anti-X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 4 (XRCC4) (AA 1-336) antibodyXRCC4 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 4 (XRCC4) (AA 151-260) antibodyXRCC4 适用: 人, 大鼠 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 4 (XRCC4) antibodyXRCC4 适用: 人 WB, ELISA, IP 宿主: 小鼠 Monoclonal unconjugated
anti-X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 4 (XRCC4) antibodyXRCC4 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 4 (XRCC4) antibodyXRCC4 适用: 人 WB, IP 宿主: 小鼠 Monoclonal 5C10 unconjugated
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- 说明
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Related Products: ABIN968535, ABIN967389
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 250 μg/mL
- 缓冲液
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store undiluted at -20° C.
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: "A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis." in: Cell, Vol. 95, Issue 7, pp. 891-902, (1999) (PubMed).
: "DNA binding of Xrcc4 protein is associated with V(D)J recombination but not with stimulation of DNA ligase IV activity." in: The EMBO journal, Vol. 18, Issue 7, pp. 2008-18, (1999) (PubMed).
: "The XRCC4 gene encodes a novel protein involved in DNA double-strand break repair and V(D)J recombination." in: Cell, Vol. 83, Issue 7, pp. 1079-89, (1996) (PubMed).
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: "A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis." in: Cell, Vol. 95, Issue 7, pp. 891-902, (1999) (PubMed).
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- 抗原
- XRCC4 (X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 4 (XRCC4))
- 别名
- XRCC4 (XRCC4 产品)
- 别名
- zgc:73312 antibody, MGC81443 antibody, homolog of human DNA ligase iv-binding protein XRCC4 antibody, 2310057B22Rik antibody, AW413319 antibody, AW545101 antibody, X-ray repair cross complementing 4 antibody, X-ray repair complementing defective repair in Chinese hamster cells 4 antibody, X-ray repair complementing defective repair in Chinese hamster cells 4 L homeolog antibody, DNA ligase IV-binding protein antibody, XRCC4 antibody, xrcc4 antibody, xrcc4.L antibody, Xrcc4 antibody
- 背景
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DNA double-strand breaks (DSB) are generated during intrinsic eukaryotic DNA recombination events such as assembly of antigen receptor genes and meiotic and mitotic recombination. DSB repair proteins are also required to repair breaks induced by extrinsic factors such as ionizing radiation and mutagenic chemicals. DNA-PKcs, Ku70/Ku80, DNA ligase IV, and X-Ray Cross Complementation group 4 (XRCC4) are DSB proteins involved in both V(D)J recombination and DNA double-stranded break repair. XRCC4 activates DNA ligase IV and cells deficient in XRCC4 inefficiently form coding joints and signal joints during V(D)J recombination. XRCC4 contains a C-terminal nuclear localization sequence (NLS) and multiple phosphorylation sites, binds DNA, and is an effective substrate for DNA-PK. Phosphorylation of XRCC4 has no effect on its interactions with DNA ligase IV or end-joining activity, but can inhibit its DNA binding activity. Mice deficient in XRCC4 exhibit defects in lymphogenesis and apoptotic death of postmitotic neurons during neurogenesis. Thus, XRCC4 is a ubiquitous protein involved in DNA end joining during DNA recombination and repair, which is critical for cell growth and survival.
Synonyms: X-Ray Cross Complementation group 4 - 分子量
- 55 kDa
- 途径
- DNA Damage Repair, Production of Molecular Mediator of Immune Response
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