APBA3 抗体 (AA 63-185)
(3 references)-
- 抗原 See all APBA3 抗体
- APBA3 (Amyloid beta (A4) Precursor Protein-Binding, Family A, Member 3 (APBA3))
-
抗原表位
- AA 63-185
-
适用
- 人, 小鼠
-
宿主
- 小鼠
-
克隆类型
- 单克隆
-
标记
- This APBA3 antibody is un-conjugated
-
应用范围
- Western Blotting (WB), Immunofluorescence (IF), BioImaging (BI)
- 交叉反应
- 人
- 产品特性
-
1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing. - 纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- 免疫原
- Mouse Mint3 aa. 63-185
- 克隆位点
- 32-Mint3
- 亚型
- IgG1
- Top Product
- Discover our top product APBA3 Primary Antibody
-
anti-Amyloid beta (A4) Precursor Protein-Binding, Family A, Member 3 (APBA3) (AA 241-340) antibody
APBA3 适用: 小鼠 WB, ELISA, IF (cc), IF (p), IHC (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Amyloid beta (A4) Precursor Protein-Binding, Family A, Member 3 (APBA3) (N-Term) antibodyAPBA3 适用: 人, 大鼠 WB, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Amyloid beta (A4) Precursor Protein-Binding, Family A, Member 3 (APBA3) (AA 144-193) antibodyAPBA3 适用: 人, 犬 WB 宿主: 兔 Polyclonal unconjugated
anti-Amyloid beta (A4) Precursor Protein-Binding, Family A, Member 3 (APBA3) (AA 261-506) antibodyAPBA3 适用: 小鼠 WB, IHC, ICC 宿主: 兔 Polyclonal unconjugated
-
- 说明
-
Related Products: ABIN967389
- 限制
- 仅限研究用
-
- 状态
- Liquid
- 浓度
- 250 μg/mL
- 缓冲液
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store undiluted at -20°C.
-
-
: "Mint2/X11-like colocalizes with the Alzheimer's disease amyloid precursor protein and is associated with neuritic plaques in Alzheimer's disease." in: The European journal of neuroscience, Vol. 11, Issue 6, pp. 1988-94, (1999) (PubMed).
: "Identification of an evolutionarily conserved heterotrimeric protein complex involved in protein targeting." in: The Journal of biological chemistry, Vol. 273, Issue 48, pp. 31633-6, (1998) (PubMed).
: "The X11alpha protein slows cellular amyloid precursor protein processing and reduces Abeta40 and Abeta42 secretion." in: The Journal of biological chemistry, Vol. 273, Issue 24, pp. 14761-6, (1998) (PubMed).
-
: "Mint2/X11-like colocalizes with the Alzheimer's disease amyloid precursor protein and is associated with neuritic plaques in Alzheimer's disease." in: The European journal of neuroscience, Vol. 11, Issue 6, pp. 1988-94, (1999) (PubMed).
-
- 抗原
- APBA3 (Amyloid beta (A4) Precursor Protein-Binding, Family A, Member 3 (APBA3))
- 别名
- Mint3 (APBA3 产品)
- 别名
- AW208791 antibody, Mint-3 antibody, X11gamma antibody, lin-10 antibody, mint3 antibody, MGC:15815 antibody, X11L2 antibody, Mint3 antibody, amyloid beta precursor protein binding family A member 3 antibody, amyloid beta (A4) precursor protein-binding, family A, member 3 antibody, APBA3 antibody, Apba3 antibody
- 背景
-
Munc18-1-interacting proteins, Mint1, Mint2, and Mint3, are members of the X11 family of proteins, which contain a phosphotyrosine-binding (PTB) domain and two PSD-95-DLG-ZO-1 (PDZ) domains. The PTB domain binds Asn-Pro-X-pTyr, a beta-turn motif found on activated growth factor receptors and other signaling molecules. PDZ domains bind the C-terminus of proteins involved in receptor and channel clustering and protein localization in polarized cells. Both Mint1 and Mint2 are expressed primarily in the nervous system and may interact with Munc18-1 and syntaxin to form a multimeric complex that mediates appropriate docking/fusion of synaptic vesicles. In addition, both Mint1 and Mint2 may be involved in Alzheimer's disease, since Mint2 colocalizes with amyloid precursor protein (APP) and is found in neuritic plaques, while Mint1 can bind APP, and inhibits the processing of APP to the amyloid beta peptide. Mint3 can also bind APP, but differs from Mint1 and Mint2 in its N-terminal region. It is also more widely expressed. Thus, Mint3 may function in signaling pathways, vesicle exocytosis, and/or protein targeting in a wide range of tissues. Mint3 has a calculated molecular weight of 61 kD, but reportedly is observed migrating at 86-89 kD. This antibody is routinely tested by western blot analysis.
Synonyms: X11gamma - 分子量
- 86-89 kDa
-
