AP3D1 抗体 (Adaptor-Related Protein Complex 3, delta 1 Subunit) (AA 627-731)

Details for Product anti-AP3D1 Antibody No. ABIN968476, 供应商: Log in to see
抗原
  • wu:fj51g01
  • si:ch211-129c21.6
  • ADTD
  • hBLVR
  • AA407035
  • Ap3d
  • Bolvr
  • mBLVR1
  • mh
  • mocha
  • BLVR
  • adaptor-related protein complex 3, delta 1 subunit
  • AP-3 complex subunit delta-1
  • adaptor related protein complex 3 delta 1 subunit
  • ap3d1
  • EDI_172030
  • EHI_158840
  • Tsp_04773
  • AP3D1
  • Ap3d1
抗原表位
AA 627-731
8
2
2
2
1
1
适用

29
4
4
3
1
1
宿主
小鼠
18
9
2
克隆类型 (克隆位点)
单克隆 ()
应用范围
Immunofluorescence (IF), Western Blotting (WB)
24
17
8
5
4
2
2
2
选项
Supplier
Log in to see
Supplier Product No.
Log in to see
免疫原 Human Adaptin delta aa. 627-731
克隆位点 18-Adaptin delta
亚型 IgG1
产品特性 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
纯化方法 The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
别名 Adaptin delta (AP3D1 Antibody 摘要)
背景 Sorting of integral membrane proteins at various stages of the endocytic and secretory pathways is mediated by vesicular trafficking between a variety of organelles. Two sorting signals are tyrosine-based and dileucine-based signals that interact with heterotetrameric adaptor protein complexes (AP-1 through AP-4), which are associated with the vesicle coats. These coatomers contain two large adaptin proteins (gamma, alpha, delta, epsilon and beta1, beta2, beta3, beta4, respectively) that are noncovalently linked to one medium chain (µ1, µ2, µ3, or µ4) and one small chain (sigma1, sigma2, sigma3, or sigma4). The AP-1 and AP-3 complexes are involved in protein sorting from the TGN and endosomes, while AP-2 adaptor complexes are involved in clathrin-mediated endocytosis. In the AP-3 complex, adaptin delta contains an N-terminal head domain that has 25% identity with adaptins alpha and gamma, while its C-terminal hinge and ear domains are two-fold larger and more divergent as compared to the same domains in adaptins alpha and gamma. Adaptin delta is widely expressed and its mutation results in protein storage deficiencies within lysosomal-related organelles in platelets, melansomes, and synaptic vesicles. This antibody is routinely tested by western blot analysis.
分子量 160 kDa
说明

Related Products: ABIN968535, ABIN967389

限制 仅限研究用
状态 Liquid
浓度 250 μg/mL
缓冲液 Aqueous buffered solution containing BSA, glycerol.
储存条件 -20 °C
储存方法 Store undiluted at -20° C.
厂商提供的图像
Western Blotting (WB) image for anti-Adaptor-Related Protein Complex 3, delta 1 Subunit (AP3D1) (AA 627-731) antibody (ABIN968476) Western blot analysis of Adaptin delta on a HeLa lysate. Lane 1: 1:500, lane 2: 1:100...
 image for anti-Adaptor-Related Protein Complex 3, delta 1 Subunit (AP3D1) (AA 627-731) antibody (ABIN968476) Immunoflourescence staining of ES2 cells.
有引用在: Blumstein, Faundez, Nakatsu, Saito, Ohno, Kelly: "The neuronal form of adaptor protein-3 is required for synaptic vesicle formation from endosomes." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 21, Issue 20, pp. 8034-42, 2001 (PubMed).

Zhen, Jiang, Feng, Bright, Peden, Seymour, Novak, Elliott, Gorin, Robinson, Swank: "Abnormal expression and subcellular distribution of subunit proteins of the AP-3 adaptor complex lead to platelet storage pool deficiency in the pearl mouse." in: Blood, Vol. 94, Issue 1, pp. 146-55, 1999 (PubMed).

Le Borgne, Alconada, Bauer, Hoflack: "The mammalian AP-3 adaptor-like complex mediates the intracellular transport of lysosomal membrane glycoproteins." in: The Journal of biological chemistry, Vol. 273, Issue 45, pp. 29451-61, 1998 (PubMed).

Ooi, Moreira, DellAngelica, Poy, Wassarman, Bonifacino: "Altered expression of a novel adaptin leads to defective pigment granule biogenesis in the Drosophila eye color mutant garnet." in: The EMBO journal, Vol. 16, Issue 15, pp. 4508-18, 1997 (PubMed).

您还需要查找其他产品吗?