FYN 抗体 (AA 1-132)
(4 references)-
- 抗原 See all FYN 抗体
- FYN (FYN Oncogene Related To SRC, FGR, YES (FYN))
-
抗原表位
- AA 1-132
-
适用
- 人, 大鼠, 犬
-
宿主
- 小鼠
-
克隆类型
- 单克隆
-
标记
- This FYN antibody is un-conjugated
-
应用范围
- Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF)
- 交叉反应
- 犬, 大鼠
- 产品特性
-
1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing. - 纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- 免疫原
- Human fyn aa. 1-132
- 克隆位点
- 25-FYN
- 亚型
- IgG2b
- Top Product
- Discover our top product FYN Primary Antibody
-
anti-FYN Oncogene Related To SRC, FGR, YES (FYN) (AA 7-176) antibody
FYN 适用: 人, 小鼠 WB, IHC (p), IP, ICC 宿主: 小鼠 Monoclonal FYN-01 unconjugated
anti-FYN Oncogene Related To SRC, FGR, YES (FYN) antibodyFYN 适用: 人 WB, ELISA, IHC, FACS, ICC 宿主: 小鼠 Monoclonal 2A10 unconjugated
anti-FYN Oncogene Related To SRC, FGR, YES (FYN) (pTyr530) antibodyFYN 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-FYN Oncogene Related To SRC, FGR, YES (FYN) (AA 13-43) antibodyFYN 适用: 人, 小鼠 WB, ELISA, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-FYN Oncogene Related To SRC, FGR, YES (FYN) (AA 1-537) antibodyFYN 适用: 人 WB, PLA 宿主: 兔 Polyclonal unconjugated
anti-FYN Oncogene Related To SRC, FGR, YES (FYN) (AA 7-176) antibodyFYN 适用: 人 WB, IP, IF, ICC 宿主: 小鼠 Monoclonal FYN-01 unconjugated
anti-FYN Oncogene Related To SRC, FGR, YES (FYN) (AA 1-30) antibodyFYN 适用: 人 WB, ELISA, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-FYN Oncogene Related To SRC, FGR, YES (FYN) (pTyr530) antibodyFYN 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-FYN Oncogene Related To SRC, FGR, YES (FYN) (pTyr530) antibodyFYN 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-FYN Oncogene Related To SRC, FGR, YES (FYN) (AA 1-482) antibodyFYN 适用: 人 WB, ELISA, PLA 宿主: 小鼠 Monoclonal 3G11-F9 unconjugated
-
- 说明
-
Related Products: ABIN968537, ABIN967389
- 限制
- 仅限研究用
-
- 状态
- Liquid
- 浓度
- 250 μg/mL
- 缓冲液
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store undiluted at -20° C.
-
-
: "PTP alpha regulates integrin-stimulated FAK autophosphorylation and cytoskeletal rearrangement in cell spreading and migration." in: The Journal of cell biology, Vol. 160, Issue 1, pp. 137-46, (2003) (PubMed).
: "The distinct capacity of Fyn and Lck to phosphorylate Sam68 in T cells is essentially governed by SH3/SH2-catalytic domain linker interactions." in: Oncogene, Vol. 21, Issue 47, pp. 7205-13, (2002) (PubMed).
: "Dual role of Fyn in the regulation of FAK+6,7 by cannabinoids in hippocampus." in: The Journal of biological chemistry, Vol. 276, Issue 41, pp. 38289-96, (2001) (PubMed).
: "Acquisition of transforming properties by FYN, a normal SRC-related human gene." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 85, Issue 11, pp. 3870-4, (1988) (PubMed).
-
: "PTP alpha regulates integrin-stimulated FAK autophosphorylation and cytoskeletal rearrangement in cell spreading and migration." in: The Journal of cell biology, Vol. 160, Issue 1, pp. 137-46, (2003) (PubMed).
-
- 抗原
- FYN (FYN Oncogene Related To SRC, FGR, YES (FYN))
- 别名
- Fyn (FYN 产品)
- 别名
- im:6908851 antibody, si:dkey-119m7.5 antibody, zgc:109996 antibody, c-fyn antibody, cfyn-a antibody, SLK antibody, SYN antibody, p59-FYN antibody, PKC antibody, fyn antibody, zgc:86720 antibody, AI448320 antibody, AW552119 antibody, FYN proto-oncogene, Src family tyrosine kinase antibody, FYN proto-oncogene, Src family tyrosine kinase S homeolog antibody, FYN proto-oncogene, Src family tyrosine kinase b antibody, FYN proto-oncogene, Src family tyrosine kinase L homeolog antibody, FYN proto-oncogene, Src family tyrosine kinase a antibody, Fyn proto-oncogene antibody, FYN antibody, fyn.S antibody, fynb antibody, fyn.L antibody, Fyn antibody, fyna antibody
- 背景
- Stimulation of the T cell antigen receptor (TcR) results in protein tyrosine phosphorylation via non-receptor tyrosine kinases. The src-related p59[fyn] kinase is one such enzyme that associates with the TcR. Ligation of the TcR activates the protein kinase activity of p59[fyn] in various human T cells. Fyn interacts with the CD3-zeta chains through its N-terminal region. In turn, fyn binds other proteins through its SH2 and SH3 domains. These proteins (p82 and p116) may serve as substrates and/or mediators of fyn activity. A 72 kDa fyn-related protein binds to the TcR/CD3 complex in certain T cells. This protein, known as p72[fyn-R], is a variant of the fyn kinase and contains at least four novel Ser/Thr phosphorylation sites. These sites may make p72[fyn-R] less susceptible to the action of phosphatases than p59[fyn]. Like p59[fyn], p72[fyn-R] is constitutively associated with its receptor. The exact relationship between these two proteins is not yet clear. However, p72[fyn-R] immunoprecipitates with various antisera raised to either the N- or C-terminus of fyn. Similar to src and yes, fyn is highly expressed in brain. The localization of fyn in mouse brain and its interaction with myelin-associated glycoprotein (MAG) suggests that the fyn kinase has a role in the sensory network and in myelination during early stages of CNS formation.
- 分子量
- 59 kDa
- 途径
- JAK/STAT Signaling, TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Feeding Behaviour, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, Activated T Cell Proliferation, Thromboxane A2 Receptor Signaling
-
