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TRKB 抗体 (AA 156-322)

Name: TRKB 抗体 (AA 156-322)
SKU: ABIN967745
Availability: OutOfStock

NTRK2 适用: 大鼠 WB, IHC, IP, BI, FM 宿主: 小鼠 Monoclonal 47-TrkB unconjugated

Western blot analysis of TrkB on a rat cerebrum lysate (left).

Immunofluorescent staining of undifferentiated (left) and differentiated (right) SH-SY5Y cells (ATCC CRL-2266, Human neuroblastoma).

Immunofluorescent staining of differentiated SH-SY5Y cells

3 images

(6 references)

产品编号 ABIN967745

发货至: 中国

Datasheet as PDF

抗原 See all TRKB (NTRK2) 抗体

TRKB (NTRK2) (Neurotrophic Tyrosine Kinase, Receptor, Type 2 (NTRK2))
抗原表位
16

15

12

12

10

10

9

8

7

7

6

4

4

4

4

3

3

3

3

3

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 156-322
适用
133

89

85

6

6

5

4

3

3

1

1

1

1

1
大鼠
宿主
137

7

4

1

1
小鼠
Compatible Secondaries
克隆类型
130

20
单克隆
标记
81

8

6

6

6

6

6

6

5

4

3

2

2

2

2

2

2

1
This TRKB antibody is un-conjugated
应用范围
106

53

50

21

19

18

15

14

7

5

3

2

1

1

1
Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), BioImaging (BI), Fluorescence Microscopy (FM)

交叉反应

大鼠, 小鼠

产品特性

1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.

纯化方法

The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

免疫原

Human TrkB aa. 156-322

克隆位点

47-TrkB

亚型

IgG1

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anti-Neurotrophic Tyrosine Kinase, Receptor, Type 2 (NTRK2) (AA 401-500) antibody
NTRK2 适用: 人, 大鼠 WB, ELISA, IHC (p), FACS, IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Neurotrophic Tyrosine Kinase, Receptor, Type 2 (NTRK2) (pTyr706) antibody
NTRK2 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Neurotrophic Tyrosine Kinase, Receptor, Type 2 (NTRK2) (pTyr516) antibody
NTRK2 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Neurotrophic Tyrosine Kinase, Receptor, Type 2 (NTRK2) (AA 32-282) antibody
NTRK2 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated

anti-Neurotrophic Tyrosine Kinase, Receptor, Type 2 (NTRK2) (AA 207-339) antibody
NTRK2 适用: 人 WB, IHC, ELISA, FACS, ICC 宿主: 小鼠 Monoclonal 10B6C4 unconjugated

anti-Neurotrophic Tyrosine Kinase, Receptor, Type 2 (NTRK2) (AA 57-70), (Extracellular Domain) antibody
NTRK2 适用: 人, 大鼠, 小鼠 WB, IHC, IF, FACS, ICC, LCI 宿主: 兔 Polyclonal unconjugated

anti-Neurotrophic Tyrosine Kinase, Receptor, Type 2 (NTRK2) (pTyr817) antibody
NTRK2 适用: 人, 小鼠 WB, IHC (p), IF (cc) 宿主: 兔 Monoclonal 2A1 unconjugated

anti-Neurotrophic Tyrosine Kinase, Receptor, Type 2 (NTRK2) antibody
NTRK2 适用: 人, 大鼠 IHC 宿主: 兔 Polyclonal unconjugated

anti-Neurotrophic Tyrosine Kinase, Receptor, Type 2 (NTRK2) (AA 1-477) antibody
NTRK2 适用: 人 WB, PLA 宿主: 兔 Polyclonal unconjugated

anti-Neurotrophic Tyrosine Kinase, Receptor, Type 2 (NTRK2) (C-Term) antibody
NTRK2 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

说明

Related Products: ABIN968545, ABIN967389

限制

仅限研究用
状态

Liquid

浓度

250 μg/mL

缓冲液

Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C

储存方法

Store undiluted at -20°C.
Du, Feng, Yang, Lu: "Activity- and Ca(2+)-dependent modulation of surface expression of brain-derived neurotrophic factor receptors in hippocampal neurons." in: The Journal of cell biology, Vol. 150, Issue 6, pp. 1423-34, (2000) (PubMed).

Muller, Djebbara-Hannas, Jourdain, Vutskits, Durbec, Rougon, Kiss: "Brain-derived neurotrophic factor restores long-term potentiation in polysialic acid-neural cell adhesion molecule-deficient hippocampus." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, Issue 8, pp. 4315-20, (2000) (PubMed).

Jovanovic, Czernik, Fienberg, Greengard, Sihra: "Synapsins as mediators of BDNF-enhanced neurotransmitter release." in: Nature neuroscience, Vol. 3, Issue 4, pp. 323-9, (2000) (PubMed).

Kryl, Yacoubian, Haapasalo, Castren, Lo, Barker: "Subcellular localization of full-length and truncated Trk receptor isoforms in polarized neurons and epithelial cells." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 19, Issue 14, pp. 5823-33, (1999) (PubMed).

Armanini, McMahon, Sutherland, Shelton, Phillips: "Truncated and catalytic isoforms of trkB are co-expressed in neurons of rat and mouse CNS." in: The European journal of neuroscience, Vol. 7, Issue 6, pp. 1403-9, (1995) (PubMed).

Ebendal: "Function and evolution in the NGF family and its receptors." in: Journal of neuroscience research, Vol. 32, Issue 4, pp. 461-70, (1992) (PubMed).
抗原

TRKB (NTRK2) (Neurotrophic Tyrosine Kinase, Receptor, Type 2 (NTRK2))

别名

TrkB (NTRK2 产品)

别名

trkb antibody, trkb-b antibody, xtrkb antibody, si:ch211-220b11.1 antibody, trkB2 antibody, NTRK2 antibody, ntrk2 antibody, gp145-trkb antibody, TRKB antibody, GP145-TrkB antibody, trk-B antibody, AI848316 antibody, C030027L06Rik antibody, Tkrb antibody, trkB antibody, RATTRKB1 antibody, TRKB1 antibody, Trk-B antibody, TrkB antibody, neurotrophic receptor tyrosine kinase 2 antibody, neurotrophic receptor tyrosine kinase 2 L homeolog antibody, neurotrophic tyrosine kinase, receptor, type 2b antibody, neurotrophic receptor tyrosine kinase 2 S homeolog antibody, neurotrophic tyrosine kinase, receptor, type 2 antibody, NTRK2 antibody, ntrk2.L antibody, ntrk2b antibody, ntrk2.S antibody, ntrk2 antibody, Ntrk2 antibody

背景

The full-length TrkB gene has been reported to encode for a 145 kDa glycosylated transmembrane tyrosine kinase and neurotrophin receptor. The same gene also has been reported to encode for a 95 kDa glycoprotein that is identical to gp145 [TrkB] at the extracellular domain and transmembrane portion but lacks the intracellular portion. TrkB has been observable in a range of 116-145 kD and 70-95 kD due to various TrkB maturation states, subcellular localizations, and glycosylation states. TrkB belongs to a family of tyrosine kinases that include the TrkA proto-oncogene and TrkC. All have an extracellular ligand-binding domain, a transmembrane region, and intracellular kinase and autophosphorylation domains. TrkB binds the neurotrophins NT3 and NT4/5, as well as brain-derived neurotrophic factor (BDNF), a peptide that helps motor neuron survival and repair. The TrkB tyrosine kinase is activated upon binding to BDNF resulting in autophosphorylation of residues Y670, Y674 and Y675 and the subsequent association of several intracellular proteins like PLCgamma, Shc, and PI3-Kinase. TrkB is widely expressed in cells of neuroepithelium and neural crest origin. Some of these include motor neurons, dopamine-producing neurons, and neurons which release gamma-aminobutyric acid in the substantia nigra, neocortex, and hippocampus. The two TrkB gene products are differentially expressed in regions of the adult brain.
Synonyms: Neurotrophic Tyrosine Kinase Receptor Type 2, NTRK2

分子量

116-145 & 70-95 kDa

途径

RTK signaling, Neurotrophin Signaling Pathway, cAMP Metabolic Process, Skeletal Muscle Fiber Development, Feeding Behaviour, Dicarboxylic Acid Transport