RASA1 抗体 (AA 381-390)
(5 references)-
- 抗原 See all RASA1 抗体
- RASA1 (RAS P21 Protein Activator (GTPase Activating Protein) 1 (RASA1))
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抗原表位
- AA 381-390
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适用
- 人, 大鼠, 小鼠, 犬, 小鸡, Frog
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This RASA1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)
- 交叉反应
- 犬, 大鼠, 小鼠, 小鸡, Frog
- 产品特性
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing. - 纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- 免疫原
- Human Ras-GAP aa.381-390
- 克隆位点
- 13-RAS
- 亚型
- IgG1
- Top Product
- Discover our top product RASA1 Primary Antibody
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anti-RAS P21 Protein Activator (GTPase Activating Protein) 1 (RASA1) (AA 948-1047) antibody
RASA1 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 2C12 unconjugated
anti-RAS P21 Protein Activator (GTPase Activating Protein) 1 (RASA1) (AA 948-1047) antibodyRASA1 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 1E6 unconjugated
anti-RAS P21 Protein Activator (GTPase Activating Protein) 1 (RASA1) (AA 403-596) antibodyRASA1 适用: 人 WB, ELISA, IHC (p), IHC (fro), ICC 宿主: 兔 Polyclonal unconjugated
anti-RAS P21 Protein Activator (GTPase Activating Protein) 1 (RASA1) (AA 201-500) antibodyRASA1 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-RAS P21 Protein Activator (GTPase Activating Protein) 1 (RASA1) antibodyRASA1 适用: 人, 大鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-RAS P21 Protein Activator (GTPase Activating Protein) 1 (RASA1) (AA 1-870) antibodyRASA1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-RAS P21 Protein Activator (GTPase Activating Protein) 1 (RASA1) (C-Term) antibodyRASA1 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-RAS P21 Protein Activator (GTPase Activating Protein) 1 (RASA1) antibodyRASA1 适用: 人 WB, IF 宿主: 小鼠 Monoclonal 4E2 unconjugated
anti-RAS P21 Protein Activator (GTPase Activating Protein) 1 (RASA1) (AA 140-220) antibodyRASA1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-RAS P21 Protein Activator (GTPase Activating Protein) 1 (RASA1) (AA 1-870) antibodyRASA1 适用: 人 IP 宿主: 兔 Polyclonal unconjugated
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- 说明
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Related Products: ABIN968619, ABIN967389
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 250 μg/mL
- 缓冲液
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store undiluted at -20° C.
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: "Dynamic regulation of the Ras pathway via proteolysis of the NF1 tumor suppressor." in: Genes & development, Vol. 17, Issue 4, pp. 449-54, (2003) (PubMed).
: "Annexin V inhibits the 12-O-tetradecanoylphorbol-13-acetate-induced activation of Ras/extracellular signal-regulated kinase (ERK) signaling pathway upstream of Shc in MCF-7 cells." in: Oncogene, Vol. 19, Issue 25, pp. 2904-12, (2000) (PubMed).
: "Formation of complexes involving RasGAP and p190 RhoGAP during morphogenetic events of the gastrulation in xenopus." in: European journal of biochemistry / FEBS, Vol. 265, Issue 2, pp. 530-8, (1999) (PubMed).
: "PDGF beta-receptor stimulates tyrosine phosphorylation of GAP and association of GAP with a signaling complex." in: Cell, Vol. 61, Issue 1, pp. 125-33, (1990) (PubMed).
: "PDGF induction of tyrosine phosphorylation of GTPase activating protein." in: Nature, Vol. 342, Issue 6250, pp. 711-4, (1990) (PubMed).
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: "Dynamic regulation of the Ras pathway via proteolysis of the NF1 tumor suppressor." in: Genes & development, Vol. 17, Issue 4, pp. 449-54, (2003) (PubMed).
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- 抗原
- RASA1 (RAS P21 Protein Activator (GTPase Activating Protein) 1 (RASA1))
- 别名
- Ras-GAP (RASA1 产品)
- 别名
- CG9209 antibody, D-RasGAP antibody, Dmel\\CG9209 antibody, RAS-GAP antibody, RasGAP antibody, RasGap antibody, rasGap antibody, CM-AVM antibody, CMAVM antibody, GAP antibody, PKWS antibody, RASA antibody, RASGAP antibody, p120GAP antibody, p120RASGAP antibody, GAPX antibody, Rasa antibody, Gap antibody, vacuolar peduncle antibody, RAS p21 protein activator 1 antibody, vap antibody, RASA1 antibody, Rasa1 antibody
- 背景
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Ras-GAP, a protein of approximately 120kDa, is thought to serve as a down-regulator of p21ras by stimulating its otherwise weak intrinsic GTPase activity. Both growth factor receptor and oncogene-encoded tyrosine kinases require functional membrane-associated Ras proteins in order to affect mitogenesis. The manner in which p21ras acts as a signal transducer is still a matter of speculation. The Ras-GTPase stimulating activity has been found to reside in the carboxy-terminal region of Ras-GAP, while the amino-terminal region contains two SH2 domains and an intervening SH3 domain. In cells stimulated with EGF or transformed by pp60 [v-src], Ras-GAP becomes phosphorylated on both tyrosine and serine residues and forms distinct complexes with two phosphorylated proteins of 62 and 190kDa. The tyrosine phosphorylation of Ras-GAP may modulate its subcellular localization and activity as a negative regulator of p21ras.
This antibody routinely tested by western blot analysis. - 分子量
- 120 kDa
- 途径
- Regulation of Actin Filament Polymerization, Signaling of Hepatocyte Growth Factor Receptor, VEGFR1 Specific Signals
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