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Ret Proto-Oncogene 抗体 (AA 896-1063)

RET 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 6E4C4 unconjugated
产品编号 ABIN966962
发货至: 中国
  • 抗原 See all Ret Proto-Oncogene (RET) 抗体
    Ret Proto-Oncogene (RET)
    抗原表位
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    AA 896-1063
    适用
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    宿主
    • 186
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    小鼠
    克隆类型
    • 181
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    单克隆
    标记
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    This Ret Proto-Oncogene antibody is un-conjugated
    应用范围
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    Western Blotting (WB), ELISA
    纯化方法
    Ascitic fluid
    免疫原
    Purified recombinant fragment of RET (aa896-1063) expressed in E. Coli.
    克隆位点
    6E4C4
    亚型
    IgG1
    Top Product
    Discover our top product RET Primary Antibody
  • 应用备注
    Western Bloting: 1/500 - 1/2000.
    ELISA: Propose dilution 1/10000.
    Not yet tested in other applications.
    Determining optimal working dilutions by titration test.
    限制
    仅限研究用
  • 状态
    Liquid
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C
  • 抗原
    Ret Proto-Oncogene (RET)
    别名
    RET (RET 产品)
    别名
    c-ret antibody, cret antibody, etID315074.13 antibody, ret1 antibody, wu:fd13h01 antibody, X-ret antibody, ret-A antibody, xret antibody, RET antibody, MTC1 antibody, CDHF12 antibody, CDHR16 antibody, HSCR1 antibody, MEN2A antibody, MEN2B antibody, PTC antibody, RET-ELE1 antibody, RET51 antibody, RET9 antibody, c-Ret antibody, ret proto-oncogene receptor tyrosine kinase antibody, ret proto-oncogene S homeolog antibody, ret proto-oncogene antibody, ret antibody, ret.S antibody, RET antibody, Ret antibody
    背景
    RET (ret proto-oncogene) is a member of the cadherin superfamily and a receptor tyrosine kinase, which are cellsurface molecules that transduce signals for cell growth and differentiation. It can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Ligands that bind the Ret receptor include the glial cell line-derived neurotropic factor (GDNF) and its congeners neurturin, persephin and artemin. Alterations in the corresponding Ret gene are associated with diseases including papillary thyroid carcinoma, multiple endocrine neoplasia (type 2A and 2B), familial medullary thyroid carcinoma and a congenital developmental disorder known as Hirschsprung disease. The Tyr905 residue located in the Ret kinase domain plays a crucial role in Ret catalytic and biological activity. Substitution of Phe for Tyr905 dramatically inhibits Ret autophosphorylation activity.
    Synonyms: RET
    基因ID
    5979
    途径
    RTK signaling, Dopaminergic Neurogenesis, Regulation of Cell Size, Tube Formation
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