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LIMS1 抗体

LIMS1 适用: 人 WB, ELISA, IF, FACS 宿主: 小鼠 Monoclonal 5G7 unconjugated
产品编号 ABIN966832
发货至: 中国
  • 抗原 See all LIMS1 抗体
    LIMS1 (LIM and Senescent Cell Antigen-Like Domains 1 (LIMS1))
    适用
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    宿主
    • 49
    • 10
    小鼠
    克隆类型
    • 49
    • 10
    单克隆
    标记
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    This LIMS1 antibody is un-conjugated
    应用范围
    • 19
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    Western Blotting (WB), ELISA, Immunofluorescence (IF), Flow Cytometry (FACS)
    纯化方法
    Ascitic fluid
    免疫原
    Purified recombinant fragment of human PINCH expressed in E. Coli.
    克隆位点
    5G7
    亚型
    IgG1
    Top Product
    Discover our top product LIMS1 Primary Antibody
  • 应用备注
    Western Bloting: 1/500 - 1/2000.
    Immunofluorescence: 1/200 - 1/1000.
    Flow cytometry: 1/200 - 1/400.
    ELISA: Propose dilution 1/10000.
    Not yet tested in other applications.
    Determining optimal working dilutions by titration test.
    限制
    仅限研究用
  • 状态
    Liquid
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C
  • Yang, Wang, Hawkins, Chen, Vaynberg, Mao, Tu, Zuo, Wang, Wang, Wu, Tjandra, Qin: "Structural basis of focal adhesion localization of LIM-only adaptor PINCH by integrin-linked kinase." in: The Journal of biological chemistry, Vol. 284, Issue 9, pp. 5836-44, (2009) (PubMed).

    Chiswell, Zhang, Murphy, Boggon, Calderwood: "The structural basis of integrin-linked kinase-PINCH interactions." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 52, pp. 20677-82, (2008) (PubMed).

  • 抗原
    LIMS1 (LIM and Senescent Cell Antigen-Like Domains 1 (LIMS1))
    别名
    PINCH (LIMS1 产品)
    别名
    PINCH antibody, PINCH-1 antibody, PINCH1 antibody, Pinch1 antibody, RGD1560732 antibody, LIMS3 antibody, LIMS3L antibody, 2310016J22Rik antibody, 4921524A02Rik antibody, AI507642 antibody, AU021743 antibody, AW551584 antibody, C430041B13Rik antibody, Lims1l antibody, LIM zinc finger domain containing 1 antibody, LIM and senescent cell antigen-like domains 1 antibody, LIMS1 antibody, Lims1 antibody
    背景
    The protein encoded by this gene is an adaptor protein which contains five LIM domains, or double zinc fingers. The protein is likely involved in integrin signaling through its LIM domain-mediated interaction with integrin-linked kinase, found in focal adhesion plaques. It is also thought to act as a bridge linking integrin-linked kinase to NCK adaptor protein 2, which is involved in growth factor receptor kinase signaling pathways. Its localization to the periphery of spreading cells also suggests that this protein may play a role in integrin-mediated cell adhesion or spreading. Several transcript variants encoding different isoforms have been found for this gene.
    Synonyms: PINCH, PINCH1, PINCH-1, LIMS1
    分子量
    37kDa
    基因ID
    3987
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