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PDGFRB 抗体

PDGFRB 适用: 人, 小鼠 WB, ELISA 宿主: 小鼠 Monoclonal 1A2 unconjugated
产品编号 ABIN966814
发货至: 中国
  • 抗原 See all PDGFRB 抗体
    PDGFRB (Platelet Derived Growth Factor Receptor beta (PDGFRB))
    适用
    • 205
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    人, 小鼠
    宿主
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    • 2
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    小鼠
    克隆类型
    • 171
    • 44
    单克隆
    标记
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    This PDGFRB antibody is un-conjugated
    应用范围
    • 160
    • 81
    • 54
    • 53
    • 51
    • 36
    • 32
    • 19
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    • 12
    • 10
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    • 1
    Western Blotting (WB), ELISA
    纯化方法
    Ascitic fluid
    免疫原
    Purified recombinant fragment of human PDGFR-beta expressed in E. Coli.
    克隆位点
    1A2
    亚型
    IgG1
    Top Product
    Discover our top product PDGFRB Primary Antibody
  • 应用备注
    Western Bloting: 1/500 - 1/2000.
    ELISA: Propose dilution 1/10000.
    Not yet tested in other applications.
    Determining optimal working dilutions by titration test.
    限制
    仅限研究用
  • 状态
    Liquid
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C
  • Gredmark, Strååt, Homman-Loudiyi, Kannisto, Söderberg-Nauclér: "Human cytomegalovirus downregulates expression of receptors for platelet-derived growth factor by smooth muscle cells." in: Journal of virology, Vol. 81, Issue 10, pp. 5112-20, (2007) (PubMed).

    Ferguson: "Melanoma." in: Journal of continuing education in nursing, Vol. 36, Issue 6, pp. 242-3, (2005) (PubMed).

    Wilczynski, Chen, Chen, Howell, Shively, Alberts: "Expression and mutational analysis of tyrosine kinase receptors c-kit, PDGFRalpha, and PDGFRbeta in ovarian cancers." in: Human pathology, Vol. 36, Issue 3, pp. 242-9, (2005) (PubMed).

    Hansen, Rönnstrand, Rorsman, Hellman, Heldin: "Association of coatomer proteins with the beta-receptor for platelet-derived growth factor." in: Biochemical and biophysical research communications, Vol. 235, Issue 3, pp. 455-60, (1997) (PubMed).

  • 抗原
    PDGFRB (Platelet Derived Growth Factor Receptor beta (PDGFRB))
    别名
    PDGFRbeta (PDGFRB 产品)
    别名
    AI528809 antibody, CD140b antibody, PDGFR-1 antibody, Pdgfr antibody, CD140B antibody, IBGC4 antibody, JTK12 antibody, PDGFR antibody, PDGFR1 antibody, platelet derived growth factor receptor, beta polypeptide antibody, platelet derived growth factor receptor beta antibody, Pdgfrb antibody, PDGFRB antibody
    背景
    Platelet-derived growth factor receptor, beta polypeptide, also known as PDGFRB, PDGFRbeta or CD140B. It is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. This family exist as several disulphidebonded, dimeric isoforms (PDGF AA, PDGF AB, PDGF BB, PDGF CC and PDGF DD) that bind in a specific pattern to two closely related receptor tyrosine kinases, PDGF receptor alpha (PDGFRalpha) and PDGF receptor beta (PDGFRbeta). These growth factors are mitogens for cells of mesenchymal origin. PDGFRB is flanked on chromosome 5 by the genes for granulocyte-macrophage colonystimulating factor and macrophage-colony stimulating factor receptor, all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia.
    Synonyms: JTK12, PDGFR, CD140B, PDGFR1, PDGFRB
    分子量
    190kDa
    基因ID
    5159
    途径
    Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Inositol Metabolic Process, Glycosaminoglycan Metabolic Process, Smooth Muscle Cell Migration, Platelet-derived growth Factor Receptor Signaling
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