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MDM2 抗体 (N-Term)

MDM2 适用: 人, 大鼠 WB Polyclonal unconjugated
产品编号 ABIN966549
发货至: 中国
  • 抗原 See all MDM2 抗体
    MDM2 (Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2))
    抗原表位
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    AA 103-119, N-Term
    适用
    • 195
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    • 11
    • 2
    • 1
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    • 1
    人, 大鼠
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    克隆类型
    • 170
    • 29
    多克隆
    标记
    • 100
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    This MDM2 antibody is un-conjugated
    应用范围
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    Western Blotting (WB)
    免疫原
    A synthetic peptide corresponding to a sequence at the N-terminal of human MDM2 (103-119 aa), different from the mouse sequence by three amino acids, and rat sequence by two amino acids.
    Top Product
    Discover our top product MDM2 Primary Antibody
  • 限制
    仅限研究用
  • 溶解方式
    0.2ml of distilled water will yield a concentration of 500µg/ml.
    缓冲液
    Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4
    储存液
    Thimerosal (Merthiolate), Sodium azide
    储存条件
    -20 °C
  • Uhrinova, Uhrin, Powers, Watt, Zheleva, Fischer, McInnes, Barlow: "Structure of free MDM2 N-terminal domain reveals conformational adjustments that accompany p53-binding." in: Journal of molecular biology, Vol. 350, Issue 3, pp. 587-98, (2005) (PubMed).

  • 抗原
    MDM2 (Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2))
    别名
    MDM2 (MDM2 产品)
    别名
    ACTFS antibody, HDMX antibody, hdm2 antibody, zgc:109834 antibody, 1700007J15Rik antibody, AA415488 antibody, Mdm-2 antibody, MDM2 proto-oncogene antibody, MDM2 proto-oncogene S homeolog antibody, Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse) antibody, MDM2 oncogene, E3 ubiquitin protein ligase antibody, transformed mouse 3T3 cell double minute 2 antibody, MDM2 antibody, mdm2.S antibody, Mdm2 antibody, mdm2 antibody
    背景
    Mdm2 is an important negative regulator of the p53 tumor suppressor. It is the name of a gene as well as the protein encoded by that gene. Mdm2 protein functions both as an E3 ubiquity lipase that recognizes the N-terminal trans-activation domain (TAD) of the p53 tumor suppressor and an inhibitor of p53 transcriptional activation. Oliner et al. (1992) used MDM2 clones to localize the human gene to chromosome 12q13-q14 by analysis of human-hamster somatic cell hybrids.
    途径
    p53 Pathway, PI3K-Akt Signaling, Cell Division Cycle, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Autophagy, Ubiquitin Proteasome Pathway
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