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- 抗原 See all MDM2 抗体
- MDM2 (Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2))
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抗原表位
- AA 103-119, N-Term
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适用
- 人, 大鼠
- 宿主
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克隆类型
- 多克隆
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标记
- This MDM2 antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 免疫原
- A synthetic peptide corresponding to a sequence at the N-terminal of human MDM2 (103-119 aa), different from the mouse sequence by three amino acids, and rat sequence by two amino acids.
- Top Product
- Discover our top product MDM2 Primary Antibody
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- 限制
- 仅限研究用
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- 溶解方式
- 0.2ml of distilled water will yield a concentration of 500µg/ml.
- 缓冲液
- Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4
- 储存液
- Thimerosal (Merthiolate), Sodium azide
- 储存条件
- -20 °C
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Structure of free MDM2 N-terminal domain reveals conformational adjustments that accompany p53-binding." in: Journal of molecular biology, Vol. 350, Issue 3, pp. 587-98, (2005) (PubMed).
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Structure of free MDM2 N-terminal domain reveals conformational adjustments that accompany p53-binding." in: Journal of molecular biology, Vol. 350, Issue 3, pp. 587-98, (2005) (PubMed).
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- 抗原
- MDM2 (Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2))
- 别名
- MDM2 (MDM2 产品)
- 别名
- ACTFS antibody, HDMX antibody, hdm2 antibody, zgc:109834 antibody, 1700007J15Rik antibody, AA415488 antibody, Mdm-2 antibody, MDM2 proto-oncogene antibody, MDM2 proto-oncogene S homeolog antibody, Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse) antibody, MDM2 oncogene, E3 ubiquitin protein ligase antibody, transformed mouse 3T3 cell double minute 2 antibody, MDM2 antibody, mdm2.S antibody, Mdm2 antibody, mdm2 antibody
- 背景
- Mdm2 is an important negative regulator of the p53 tumor suppressor. It is the name of a gene as well as the protein encoded by that gene. Mdm2 protein functions both as an E3 ubiquity lipase that recognizes the N-terminal trans-activation domain (TAD) of the p53 tumor suppressor and an inhibitor of p53 transcriptional activation. Oliner et al. (1992) used MDM2 clones to localize the human gene to chromosome 12q13-q14 by analysis of human-hamster somatic cell hybrids.
- 途径
- p53 Pathway, PI3K-Akt Signaling, Cell Division Cycle, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Autophagy, Ubiquitin Proteasome Pathway
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