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USP7 抗体 (Middle Region)

USP7 适用: 人 WB, EIA 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN955493
发货至: 中国
  • 抗原 See all USP7 抗体
    USP7 (Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) (USP7))
    抗原表位
    • 17
    • 15
    • 8
    • 8
    • 6
    • 5
    • 5
    • 5
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 319-348, Middle Region
    适用
    • 99
    • 35
    • 31
    • 8
    • 6
    • 5
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    宿主
    • 88
    • 9
    • 2
    克隆类型
    • 78
    • 21
    多克隆
    标记
    • 48
    • 8
    • 6
    • 6
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    This USP7 antibody is un-conjugated
    应用范围
    • 78
    • 38
    • 30
    • 14
    • 14
    • 13
    • 12
    • 10
    • 9
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Enzyme Immunoassay (EIA)
    特异性
    This antibody detects USP7 / HAUSP (Center).
    交叉反应 (详细)
    Species reactivity (tested):Human
    纯化方法
    Protein A column followed by peptide affinity purification
    免疫原
    KLH conjugated synthetic peptide between 319-348 amino acids from the Central region of human USP7
    亚型
    Ig Fraction
    Top Product
    Discover our top product USP7 Primary Antibody
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    0.25 mg/mL
    缓冲液
    PBS with 0.09 % (W/V) sodium azide
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    4 °C/-20 °C
    储存方法
    Store at 2 - 8 °C for up to six months or (in aliquots) at -20 °C for longer.
  • 抗原
    USP7 (Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) (USP7))
    别名
    USP7 / HAUSP (USP7 产品)
    别名
    CG1490 antibody, Dmel\\CG1490 antibody, USP7 antibody, 2210010O09Rik antibody, AA409944 antibody, AA617399 antibody, AU019296 antibody, AW548146 antibody, C80752 antibody, Hausp antibody, HAUSP antibody, TEF1 antibody, UBP antibody, Ubiquitin-specific protease 7 antibody, ubiquitin carboxyl-terminal hydrolase 7 antibody, ubiquitin specific peptidase 7 antibody, Usp7 antibody, LOC100201254 antibody, USP7 antibody
    背景
    Hydrolase that deubiquitinates target proteins such as FOXO4, TP53, MDM2, PTEN and DAXX. Together with DAXX, prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of MDM2 towards TP53, thereby promoting TP53 ubiquitination and proteasomal degradation. Deubiquitinates TP53 and MDM2 and strongly stabilizes TP53 even in the presence of excess MDM2, and also induces TP53-dependent cell growth repression and apoptosis. Deubiquitination of FOXO4 in presence of hydrogen peroxide is not dependent on TP53 and inhibits FOXO4-induced transcriptional activity. In association with DAXX, is involved in the deubiquitination and translocation of PTEN from the nucleus to the cytoplasm, both processes that are counteracted by PML. Involved in cell proliferation during early embryonic development. Contributes to the overall stabilization and trans-activation capability of the herpesvirus 1 trans-acting transcriptional protein ICP0/VMW110 during HSV-1 infection.Synonyms: Deubiquitinating enzyme 7, Herpesvirus-associated ubiquitin-specific protease, Ubiquitin carboxyl-terminal hydrolase 7, Ubiquitin thioesterase 7, Ubiquitin-specific-processing protease 7
    基因ID
    7874
    NCBI登录号
    NP_003461
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