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LAT2 抗体 (AA 196-212)

LAT2 适用: 人 WB, IP, IHC (p) 宿主: 小鼠 Monoclonal NAP-03 unconjugated
产品编号 ABIN94442
发货至: 中国
  • 抗原 See all LAT2 抗体
    LAT2 (Linker For Activation of T Cells Family, Member 2 (LAT2))
    抗原表位
    • 8
    • 8
    • 7
    • 7
    • 7
    • 7
    • 6
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 196-212
    适用
    • 54
    • 24
    • 15
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    宿主
    • 48
    • 14
    • 1
    小鼠
    克隆类型
    • 49
    • 14
    单克隆
    标记
    • 40
    • 6
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This LAT2 antibody is un-conjugated
    应用范围
    • 52
    • 22
    • 17
    • 13
    • 9
    • 7
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    特异性
    The antibody NAP-03 recognizes a defined intracellular epitope (aa 196-212) of human Non-T cell Activation Linker (NTAL), also known as LAB (linker of activated B cells), a 30 kDa transmembrane adaptor protein associating with lipid raft components in the plasma membrane of B cells, NK cells and myeloid cells.
    无交叉反应
    小鼠
    交叉反应 (详细)
    Human
    纯化方法
    Purified by protein-A affinity chromatography.
    纯度
    > 95 % (by SDS-PAGE)
    免疫原
    Peptide corresponding to aa 196-212 of human NTAL coupled to KLH.
    克隆位点
    NAP-03
    亚型
    IgG2a
    Top Product
    Discover our top product LAT2 Primary Antibody
  • 应用备注
    Immunohistochemistry (paraffin sections): Recommended dilution: 5 μg/mL, positive tissue: tonsil, germinal center.
    Western blotting: Recommended dilution: 1-2 μg/mL, incubation 60 min, positive control: RAMOS human lymphoma cell line, non-reducing conditions, 12 % separating SDS-PAGE gel.
    限制
    仅限研究用
  • 浓度
    1 mg/mL
    缓冲液
    Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Do not freeze.
    储存条件
    4 °C
    储存方法
    Store at 2-8°C. Do not freeze.
  • Brdicka, Imrich, Angelisová, Brdicková, Horváth, Spicka, Hilgert, Lusková, Dráber, Novák, Engels, Wienands, Simeoni, Osterreicher, Aguado, Malissen, Schraven, Horejsí: "Non-T cell activation linker (NTAL): a transmembrane adaptor protein involved in immunoreceptor signaling." in: The Journal of experimental medicine, Vol. 196, Issue 12, pp. 1617-26, (2002) (PubMed).

  • 抗原
    LAT2 (Linker For Activation of T Cells Family, Member 2 (LAT2))
    别名
    NTAL / LAB (LAT2 产品)
    别名
    LAB antibody, NTAL antibody, WBSCR15 antibody, WBSCR5 antibody, WSCR5 antibody, LAT2 antibody, MGC139435 antibody, Ntal antibody, Wbscr5 antibody, AW125574 antibody, Wbscr15 antibody, linker for activation of T-cells family member 2 antibody, linker for activation of T cells family, member 2 antibody, LAT2 antibody, Lat2 antibody
    背景
    Linker for activation of T cells family member 2,NTAL (non-T cell activation linker), also known as LAB (linker for activation of B cells), is a 30 kDa double-palmitoylated transmembrane adaptor protein expressed by B cells, NK cells, mast cells and macrophages. It is a negative regulator of early stages of BCR-dependent B cell signaling and serves as a negative regulator also in mast cells. However, in mast cells, NTAL also contributes to some activation processes, partially overlapping with LAT function.,LAB, LAT2
    基因ID
    7462
    UniProt
    Q9GZY6
    途径
    Fc-epsilon Receptor Signaling Pathway, BCR Signaling
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