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LYN 抗体 (AA 8-238)

LYN 适用: 人, 小鼠, 大鼠 WB, IP, ICC 宿主: 小鼠 Monoclonal LYN-01 unconjugated
产品编号 ABIN94427
发货至: 中国
  • 抗原 See all LYN 抗体
    LYN (V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog (LYN))
    抗原表位
    • 22
    • 19
    • 16
    • 13
    • 9
    • 9
    • 7
    • 5
    • 5
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 8-238
    适用
    • 136
    • 98
    • 73
    • 21
    • 16
    • 15
    • 15
    • 14
    • 8
    • 4
    • 3
    • 2
    • 2
    • 1
    人, 小鼠, 大鼠
    宿主
    • 135
    • 12
    • 1
    • 1
    小鼠
    克隆类型
    • 131
    • 19
    单克隆
    标记
    • 79
    • 11
    • 11
    • 7
    • 6
    • 5
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    This LYN antibody is un-conjugated
    应用范围
    • 125
    • 63
    • 46
    • 25
    • 25
    • 22
    • 16
    • 14
    • 7
    • 7
    • 4
    • 3
    • 2
    • 1
    Western Blotting (WB), Immunoprecipitation (IP), Immunocytochemistry (ICC)
    特异性
    The antibody LYN-01 reacts with Lyn (p56/p53), a non-receptor Src-family tyrosine kinase expressed in hematopoietic tissues (intracellular antigen).
    交叉反应 (详细)
    Mouse, Human, Rat
    纯化方法
    Purified by protein-A affinity chromatography.
    纯度
    > 95 % (by SDS-PAGE)
    免疫原
    Bacterially expressed recombinant fragment of human Lyn (aa 8 - 238).
    克隆位点
    LYN-01
    亚型
    IgG1
    Top Product
    Discover our top product LYN Primary Antibody
  • 应用备注
    Western blotting: Recommended dilution: 1-2 μg/mL.
    限制
    仅限研究用
  • 浓度
    1 mg/mL
    缓冲液
    Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Do not freeze.
    储存条件
    4 °C
    储存方法
    Store at 2-8°C. Do not freeze.
  • Queval, Nicolas, Beau: "Role of Src kinases in mobilization of glycosylphosphatidylinositol-anchored decay-accelerating factor by Dr fimbria-positive adhering bacteria." in: Infection and immunity, Vol. 79, Issue 7, pp. 2519-34, (2011) (PubMed).

    Amoui, Dráberová, Tolar, Dráber: "Direct interaction of Syk and Lyn protein tyrosine kinases in rat basophilic leukemia cells activated via type I Fc epsilon receptors." in: European journal of immunology, Vol. 27, Issue 1, pp. 321-8, (1997) (PubMed).

    Dráberová, Amoui, Dráber: "Thy-1-mediated activation of rat mast cells: the role of Thy-1 membrane microdomains." in: Immunology, Vol. 87, Issue 1, pp. 141-8, (1996) (PubMed).

  • 抗原
    LYN (V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog (LYN))
    别名
    Lyn (LYN 产品)
    别名
    JTK8 antibody, p53Lyn antibody, p56Lyn antibody, lyn antibody, LYN antibody, AA407514 antibody, Hck-2 antibody, jtk8 antibody, lyn-A antibody, CH73-38P6.3 antibody, zgc:92124 antibody, LYN proto-oncogene, Src family tyrosine kinase antibody, v-yes-1 Yamaguchi sarcoma viral related oncogene homolog antibody, tyrosine-protein kinase Lyn antibody, LYN proto-oncogene, Src family tyrosine kinase L homeolog antibody, LYN antibody, lyn antibody, Lyn antibody, LOC100593961 antibody, lyn.L antibody
    背景
    LYN proto-oncogene, Src family tyrosine kinase,Lyn is a Src-family protein tyrosine kinase that is predominantly expressed in hematopoietic cells. It is associated with a number of cell surface receptors including the B cell antigen receptor (BCR) and Fc receptors. Upon their triggering, Lyn phosphorylates subunits of these receptors in a cholesterol-dependent manner, utilizing the plasma membrane lipid raft system. The phosphorylated intracellular domains of the receptors are accessible for cytoplasmic Syk tyrosine kinase, which is activated by Lyn-mediated phosphorylation and which transduces the signal to downstream adaptors. Lyn is abnormally distributed in acute myeloid leukemia cells and seems to be a novel pharmacologic target of this disease.,JTK8, p56Lyn, p53Lyn
    基因ID
    4067
    UniProt
    P07948
    途径
    Fc-epsilon Receptor Signaling Pathway, Hormone Transport, Response to Growth Hormone Stimulus, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, CXCR4-mediated Signaling Events, Thromboxane A2 Receptor Signaling, Integrin Complex, BCR Signaling
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